A Species-Specific Anti-Human P2X7 Monoclonal Antibody Reduces Graft-versus-Host Disease in Humanised Mice

A Species-Specific Anti-Human P2X7 Monoclonal Antibody Reduces Graft-versus-Host Disease in Humanised Mice

Graft-versus-host disease (GVHD) is a T cell-mediated inflammatory disorder that arises from allogeneic haematopoietic stem cell transplantation and is often fatal. The P2X7 receptor is an extracellular adenosine 5′-triphosphate-gated cation channel expressed on immune cells. Blockade of this recept...

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Bibliographic Details
Main Authors: Amal Elhage, Peter Cuthbertson, Chloe Sligar, Debbie Watson, Ronald Sluyter
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pharmaceutics
Subjects:
xenogeneic graft-versus-host disease
P2X7
P2RX7
purinergic signalling
therapeutic antibody
biologic
Online Access:https://www.mdpi.com/1999-4923/15/9/2263

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