Impact of clinical severity of stroke on the severity and recovery of visuospatial neglect.
BACKGROUND AND PURPOSE:There is growing evidence that visuospatial neglect (VSN) is associated with lower functional performance in other modalities and is not restricted to the lesioned hemisphere alone, and may also affect the non-lesioned hemisphere in severe first-ever strokes. We aimed to inves...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6028087?pdf=render |
| _version_ | 1818506776003215360 |
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| author | Tanja C W Nijboer Caroline Winters Boudewijn J Kollen Gert Kwakkel |
| author_facet | Tanja C W Nijboer Caroline Winters Boudewijn J Kollen Gert Kwakkel |
| author_sort | Tanja C W Nijboer |
| collection | DOAJ |
| description | BACKGROUND AND PURPOSE:There is growing evidence that visuospatial neglect (VSN) is associated with lower functional performance in other modalities and is not restricted to the lesioned hemisphere alone, and may also affect the non-lesioned hemisphere in severe first-ever strokes. We aimed to investigate the longitudinal association between the severity of VSN, as reflected by the extent of ipsilesional and contralesional spatial attention deficit, and clinical severity of stroke. METHODS:This is a secondary data analysis with merged data from two prospective cohort studies. Resulting in 90 patients and 8 longitudinal measurements at 1, 2, 3, 4, 5, 8, 12, and 26 weeks post-stroke onset. A letter cancellation test (LCT) was used as the primary outcome measure to demonstrate presence and severity of VSN. The clinical severity of stroke was classified using the Bamford Classification. RESULTS:No significant association between clinical severity and the number of ipsilesional, as well as contralesional, omissions on the LCT was observed. Recovery of VSN at the contralesional hemiplegic, as well as ipsilesional non-hemiplegic side, was only dependent on 'time' as a reflection of spontaneous neurobiological recovery post-stroke. The recovery of the ipsilesional extension of VSN was significantly slower for the total anterior circulation infarct (TACI) group compared to the non-TACI group. CONCLUSIONS:Larger strokes have a significant negative impact on recovery of visual attention at the non-hemiplegic side. No clinical determinants that regulate spontaneous time-dependent recovery of VSN were found. While early 'stroke severity' has been regarded as a strong predictor of functional outcome at a group level, other prognostic factors (demographic, stroke related) need to be determined. CLINICAL TRIAL REGISTRATION:EXPLICIT-stroke Trial: http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1424 Stroke Intensity Trial: http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1665. |
| first_indexed | 2024-12-10T22:09:09Z |
| format | Article |
| id | doaj.art-e0b3e8ecf7fd4a1fa825f603bf4f1418 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T22:09:09Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e0b3e8ecf7fd4a1fa825f603bf4f14182022-12-22T01:31:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01137e019875510.1371/journal.pone.0198755Impact of clinical severity of stroke on the severity and recovery of visuospatial neglect.Tanja C W NijboerCaroline WintersBoudewijn J KollenGert KwakkelBACKGROUND AND PURPOSE:There is growing evidence that visuospatial neglect (VSN) is associated with lower functional performance in other modalities and is not restricted to the lesioned hemisphere alone, and may also affect the non-lesioned hemisphere in severe first-ever strokes. We aimed to investigate the longitudinal association between the severity of VSN, as reflected by the extent of ipsilesional and contralesional spatial attention deficit, and clinical severity of stroke. METHODS:This is a secondary data analysis with merged data from two prospective cohort studies. Resulting in 90 patients and 8 longitudinal measurements at 1, 2, 3, 4, 5, 8, 12, and 26 weeks post-stroke onset. A letter cancellation test (LCT) was used as the primary outcome measure to demonstrate presence and severity of VSN. The clinical severity of stroke was classified using the Bamford Classification. RESULTS:No significant association between clinical severity and the number of ipsilesional, as well as contralesional, omissions on the LCT was observed. Recovery of VSN at the contralesional hemiplegic, as well as ipsilesional non-hemiplegic side, was only dependent on 'time' as a reflection of spontaneous neurobiological recovery post-stroke. The recovery of the ipsilesional extension of VSN was significantly slower for the total anterior circulation infarct (TACI) group compared to the non-TACI group. CONCLUSIONS:Larger strokes have a significant negative impact on recovery of visual attention at the non-hemiplegic side. No clinical determinants that regulate spontaneous time-dependent recovery of VSN were found. While early 'stroke severity' has been regarded as a strong predictor of functional outcome at a group level, other prognostic factors (demographic, stroke related) need to be determined. CLINICAL TRIAL REGISTRATION:EXPLICIT-stroke Trial: http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1424 Stroke Intensity Trial: http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1665.http://europepmc.org/articles/PMC6028087?pdf=render |
| spellingShingle | Tanja C W Nijboer Caroline Winters Boudewijn J Kollen Gert Kwakkel Impact of clinical severity of stroke on the severity and recovery of visuospatial neglect. PLoS ONE |
| title | Impact of clinical severity of stroke on the severity and recovery of visuospatial neglect. |
| title_full | Impact of clinical severity of stroke on the severity and recovery of visuospatial neglect. |
| title_fullStr | Impact of clinical severity of stroke on the severity and recovery of visuospatial neglect. |
| title_full_unstemmed | Impact of clinical severity of stroke on the severity and recovery of visuospatial neglect. |
| title_short | Impact of clinical severity of stroke on the severity and recovery of visuospatial neglect. |
| title_sort | impact of clinical severity of stroke on the severity and recovery of visuospatial neglect |
| url | http://europepmc.org/articles/PMC6028087?pdf=render |
| work_keys_str_mv | AT tanjacwnijboer impactofclinicalseverityofstrokeontheseverityandrecoveryofvisuospatialneglect AT carolinewinters impactofclinicalseverityofstrokeontheseverityandrecoveryofvisuospatialneglect AT boudewijnjkollen impactofclinicalseverityofstrokeontheseverityandrecoveryofvisuospatialneglect AT gertkwakkel impactofclinicalseverityofstrokeontheseverityandrecoveryofvisuospatialneglect |