Genetic defects in downregulation of IgE production and a new genetic classification of atopy
Atopic disorders, such as asthma, eczema and rhinitis, develop due to the interactions between genetic and environmental factors. Atopy is characterized by enhanced IgE responses to environmental antigens. The production of IgE is upregulated by Th2 cytokines, in particular interleukin (IL)-4, and d...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2004-01-01
|
| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015311011 |
| _version_ | 1819141957881954304 |
|---|---|
| author | Naomi Kondo Eiko Matsui Hideo Kaneko Zenichiro Kato Toshiyuki Fukao Takahide Teramoto Hiroaki Shikano Minako Aoki Hidenori Onishi Koji Tatebayashi Kentaro Omoya Masashi Kondo Eiji Matsukuma Kimiko Kasahara Naoko Morimoto |
| author_facet | Naomi Kondo Eiko Matsui Hideo Kaneko Zenichiro Kato Toshiyuki Fukao Takahide Teramoto Hiroaki Shikano Minako Aoki Hidenori Onishi Koji Tatebayashi Kentaro Omoya Masashi Kondo Eiji Matsukuma Kimiko Kasahara Naoko Morimoto |
| author_sort | Naomi Kondo |
| collection | DOAJ |
| description | Atopic disorders, such as asthma, eczema and rhinitis, develop due to the interactions between genetic and environmental factors. Atopy is characterized by enhanced IgE responses to environmental antigens. The production of IgE is upregulated by Th2 cytokines, in particular interleukin (IL)-4, and downregulated by Th1 cytokines, in particular interferon (IFN)-γ. In the present review, we present the genetic factors responsible for IgE production and genetic defects in the downregulation (brake) of IgE production, especially in terms of IL-12 and IL-18 signaling, mutations of the IL-12 receptor β2 chain gene and mutations of the IL-18 receptor α chain gene in atopy. Moreover, we newly present a genetic classification of atopy. There are four categories of genes that control the expression of allergic disorders, which include: (i) antigen recognition; (ii) IgE production (downregulation=brake; and upregulation); (iii) the production and release of mediators; and (iv) events on target organs. In the near future, this genetic classification will facilitate the development of tailor-made treatment. |
| first_indexed | 2024-12-22T12:02:43Z |
| format | Article |
| id | doaj.art-e0b455618a5145f6b6f244332fe5dd49 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-12-22T12:02:43Z |
| publishDate | 2004-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-e0b455618a5145f6b6f244332fe5dd492022-12-21T18:26:33ZengElsevierAllergology International1323-89302004-01-01532778510.1111/j.1440-1592.2004.00326.xGenetic defects in downregulation of IgE production and a new genetic classification of atopyNaomi KondoEiko MatsuiHideo KanekoZenichiro KatoToshiyuki FukaoTakahide TeramotoHiroaki ShikanoMinako AokiHidenori OnishiKoji TatebayashiKentaro OmoyaMasashi KondoEiji MatsukumaKimiko KasaharaNaoko MorimotoAtopic disorders, such as asthma, eczema and rhinitis, develop due to the interactions between genetic and environmental factors. Atopy is characterized by enhanced IgE responses to environmental antigens. The production of IgE is upregulated by Th2 cytokines, in particular interleukin (IL)-4, and downregulated by Th1 cytokines, in particular interferon (IFN)-γ. In the present review, we present the genetic factors responsible for IgE production and genetic defects in the downregulation (brake) of IgE production, especially in terms of IL-12 and IL-18 signaling, mutations of the IL-12 receptor β2 chain gene and mutations of the IL-18 receptor α chain gene in atopy. Moreover, we newly present a genetic classification of atopy. There are four categories of genes that control the expression of allergic disorders, which include: (i) antigen recognition; (ii) IgE production (downregulation=brake; and upregulation); (iii) the production and release of mediators; and (iv) events on target organs. In the near future, this genetic classification will facilitate the development of tailor-made treatment.http://www.sciencedirect.com/science/article/pii/S1323893015311011atopyIgE production downregulationinterferon-yinterleukin-12 receptor 02interleukin-18 receptor a |
| spellingShingle | Naomi Kondo Eiko Matsui Hideo Kaneko Zenichiro Kato Toshiyuki Fukao Takahide Teramoto Hiroaki Shikano Minako Aoki Hidenori Onishi Koji Tatebayashi Kentaro Omoya Masashi Kondo Eiji Matsukuma Kimiko Kasahara Naoko Morimoto Genetic defects in downregulation of IgE production and a new genetic classification of atopy Allergology International atopy IgE production downregulation interferon-y interleukin-12 receptor 02 interleukin-18 receptor a |
| title | Genetic defects in downregulation of IgE production and a new genetic classification of atopy |
| title_full | Genetic defects in downregulation of IgE production and a new genetic classification of atopy |
| title_fullStr | Genetic defects in downregulation of IgE production and a new genetic classification of atopy |
| title_full_unstemmed | Genetic defects in downregulation of IgE production and a new genetic classification of atopy |
| title_short | Genetic defects in downregulation of IgE production and a new genetic classification of atopy |
| title_sort | genetic defects in downregulation of ige production and a new genetic classification of atopy |
| topic | atopy IgE production downregulation interferon-y interleukin-12 receptor 02 interleukin-18 receptor a |
| url | http://www.sciencedirect.com/science/article/pii/S1323893015311011 |
| work_keys_str_mv | AT naomikondo geneticdefectsindownregulationofigeproductionandanewgeneticclassificationofatopy AT eikomatsui geneticdefectsindownregulationofigeproductionandanewgeneticclassificationofatopy AT hideokaneko geneticdefectsindownregulationofigeproductionandanewgeneticclassificationofatopy AT zenichirokato geneticdefectsindownregulationofigeproductionandanewgeneticclassificationofatopy AT toshiyukifukao geneticdefectsindownregulationofigeproductionandanewgeneticclassificationofatopy AT takahideteramoto geneticdefectsindownregulationofigeproductionandanewgeneticclassificationofatopy AT hiroakishikano geneticdefectsindownregulationofigeproductionandanewgeneticclassificationofatopy AT minakoaoki geneticdefectsindownregulationofigeproductionandanewgeneticclassificationofatopy AT hidenorionishi geneticdefectsindownregulationofigeproductionandanewgeneticclassificationofatopy AT kojitatebayashi geneticdefectsindownregulationofigeproductionandanewgeneticclassificationofatopy AT kentaroomoya geneticdefectsindownregulationofigeproductionandanewgeneticclassificationofatopy AT masashikondo geneticdefectsindownregulationofigeproductionandanewgeneticclassificationofatopy AT eijimatsukuma geneticdefectsindownregulationofigeproductionandanewgeneticclassificationofatopy AT kimikokasahara geneticdefectsindownregulationofigeproductionandanewgeneticclassificationofatopy AT naokomorimoto geneticdefectsindownregulationofigeproductionandanewgeneticclassificationofatopy |