Genetic defects in downregulation of IgE production and a new genetic classification of atopy

Genetic defects in downregulation of IgE production and a new genetic classification of atopy

Atopic disorders, such as asthma, eczema and rhinitis, develop due to the interactions between genetic and environmental factors. Atopy is characterized by enhanced IgE responses to environmental antigens. The production of IgE is upregulated by Th2 cytokines, in particular interleukin (IL)-4, and d...

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Bibliographic Details
Main Authors: Naomi Kondo, Eiko Matsui, Hideo Kaneko, Zenichiro Kato, Toshiyuki Fukao, Takahide Teramoto, Hiroaki Shikano, Minako Aoki, Hidenori Onishi, Koji Tatebayashi, Kentaro Omoya, Masashi Kondo, Eiji Matsukuma, Kimiko Kasahara, Naoko Morimoto
Format: Article
Language:English
Published: Elsevier 2004-01-01
Series:Allergology International
Subjects:
atopy
IgE production downregulation
interferon-y
interleukin-12 receptor 02
interleukin-18 receptor a
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893015311011

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