α-glucosidase inhibitors from the leaves and stems of Erythrina Variegata L. collected in Hanoi
Four secondary metabolites, including daidzein (1), genistein (2), glycitein (3), and daidzin (4) have been isolated and structural elucidated from the methanolic extract of the stems and leaves of Erythrina variegata L. collected in Hanoi city, Vietnam. These compounds showed good in vitro inhibiti...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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The University of Danang
2023-06-01
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| Series: | Tạp chí Khoa học và Công nghệ |
| Subjects: | |
| Online Access: | https://jst-ud.vn/jst-ud/article/view/8300 |
| _version_ | 1797205604631052288 |
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| author | Phi-Hung Nguyen Savanchith Xayavong Ngoc-Thao-Vy Trinh Dang Ngoc Quang Le Thi Phuong Hoa Thi-Thuy Do Thi-Ha Vu Thi-Thuc Bui Thi-Thu-Ha Trinh |
| author_facet | Phi-Hung Nguyen Savanchith Xayavong Ngoc-Thao-Vy Trinh Dang Ngoc Quang Le Thi Phuong Hoa Thi-Thuy Do Thi-Ha Vu Thi-Thuc Bui Thi-Thu-Ha Trinh |
| author_sort | Phi-Hung Nguyen |
| collection | DOAJ |
| description | Four secondary metabolites, including daidzein (1), genistein (2), glycitein (3), and daidzin (4) have been isolated and structural elucidated from the methanolic extract of the stems and leaves of Erythrina variegata L. collected in Hanoi city, Vietnam. These compounds showed good in vitro inhibition on α-glucosidase enzyme with IC50 values of 97.6 ± 0.6, 230.4 ± 0.4, 34.3 ± 0.9, and 217.2 ± 0.2 µM, respectively as compared with that of acarbose (IC50 value of 125.8 ±
1.2 µM). This finding suggests the possible application of product containing high content of these compounds from the leaves and stems of E. variegata L. for research and development of anti-obese agent. |
| first_indexed | 2024-04-24T08:53:46Z |
| format | Article |
| id | doaj.art-e0b78c1bd9ec4ee29ed77aeb6d6410b5 |
| institution | Directory Open Access Journal |
| issn | 1859-1531 |
| language | English |
| last_indexed | 2024-04-24T08:53:46Z |
| publishDate | 2023-06-01 |
| publisher | The University of Danang |
| record_format | Article |
| series | Tạp chí Khoa học và Công nghệ |
| spelling | doaj.art-e0b78c1bd9ec4ee29ed77aeb6d6410b52024-04-16T09:14:09ZengThe University of DanangTạp chí Khoa học và Công nghệ1859-15312023-06-01717410.31130/ud-jst.2023.040E8294α-glucosidase inhibitors from the leaves and stems of Erythrina Variegata L. collected in HanoiPhi-Hung Nguyen0Savanchith Xayavong1Ngoc-Thao-Vy Trinh2Dang Ngoc Quang3Le Thi Phuong Hoa4Thi-Thuy Do5Thi-Ha Vu6Thi-Thuc Bui7Thi-Thu-Ha Trinh8Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), VietnamFaculty of Chemistry, Hanoi National University of Education, VietnamUniversity of Medicine and Pharmacy at Ho Chi Minh City (UMP HCM); Faculty of Medicine and Pharmacy, Tay Nguyen University, VietnamFaculty of Chemistry, Hanoi National University of Education, VietnamFaculty of Biology, Hanoi National University of Education, VietnamInstitute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), VietnamInstitute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), VietnamInstitute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), VietnamInstitute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), VietnamFour secondary metabolites, including daidzein (1), genistein (2), glycitein (3), and daidzin (4) have been isolated and structural elucidated from the methanolic extract of the stems and leaves of Erythrina variegata L. collected in Hanoi city, Vietnam. These compounds showed good in vitro inhibition on α-glucosidase enzyme with IC50 values of 97.6 ± 0.6, 230.4 ± 0.4, 34.3 ± 0.9, and 217.2 ± 0.2 µM, respectively as compared with that of acarbose (IC50 value of 125.8 ± 1.2 µM). This finding suggests the possible application of product containing high content of these compounds from the leaves and stems of E. variegata L. for research and development of anti-obese agent.https://jst-ud.vn/jst-ud/article/view/8300erythrina variegataα-glucosidase inhibitoranti-diabeticanti-obesityvong nem |
| spellingShingle | Phi-Hung Nguyen Savanchith Xayavong Ngoc-Thao-Vy Trinh Dang Ngoc Quang Le Thi Phuong Hoa Thi-Thuy Do Thi-Ha Vu Thi-Thuc Bui Thi-Thu-Ha Trinh α-glucosidase inhibitors from the leaves and stems of Erythrina Variegata L. collected in Hanoi Tạp chí Khoa học và Công nghệ erythrina variegata α-glucosidase inhibitor anti-diabetic anti-obesity vong nem |
| title | α-glucosidase inhibitors from the leaves and stems of Erythrina Variegata L. collected in Hanoi |
| title_full | α-glucosidase inhibitors from the leaves and stems of Erythrina Variegata L. collected in Hanoi |
| title_fullStr | α-glucosidase inhibitors from the leaves and stems of Erythrina Variegata L. collected in Hanoi |
| title_full_unstemmed | α-glucosidase inhibitors from the leaves and stems of Erythrina Variegata L. collected in Hanoi |
| title_short | α-glucosidase inhibitors from the leaves and stems of Erythrina Variegata L. collected in Hanoi |
| title_sort | α glucosidase inhibitors from the leaves and stems of erythrina variegata l collected in hanoi |
| topic | erythrina variegata α-glucosidase inhibitor anti-diabetic anti-obesity vong nem |
| url | https://jst-ud.vn/jst-ud/article/view/8300 |
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