Implication of DNA methylation during lifestyle mediated weight loss
Over the past 50 years, the number of overweight/obese people increased significantly, making obesity a global public health challenge. Apart from rare monogenic forms, obesity is a multifactorial disease, most likely resulting from a concerted interaction of genetic, epigenetic and environmental fa...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-08-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1181002/full |
| _version_ | 1797751817655812096 |
|---|---|
| author | Samantha Aurich Samantha Aurich Luise Müller Peter Kovacs Peter Kovacs Maria Keller Maria Keller |
| author_facet | Samantha Aurich Samantha Aurich Luise Müller Peter Kovacs Peter Kovacs Maria Keller Maria Keller |
| author_sort | Samantha Aurich |
| collection | DOAJ |
| description | Over the past 50 years, the number of overweight/obese people increased significantly, making obesity a global public health challenge. Apart from rare monogenic forms, obesity is a multifactorial disease, most likely resulting from a concerted interaction of genetic, epigenetic and environmental factors. Although recent studies opened new avenues in elucidating the complex genetics behind obesity, the biological mechanisms contributing to individual’s risk to become obese are not yet fully understood. Non-genetic factors such as eating behaviour or physical activity are strong contributing factors for the onset of obesity. These factors may interact with genetic predispositions most likely via epigenetic mechanisms. Epigenome-wide association studies or methylome-wide association studies are measuring DNA methylation at single CpGs across thousands of genes and capture associations to obesity phenotypes such as BMI. However, they only represent a snapshot in the complex biological network and cannot distinguish between causes and consequences. Intervention studies are therefore a suitable method to control for confounding factors and to avoid possible sources of bias. In particular, intervention studies documenting changes in obesity-associated epigenetic markers during lifestyle driven weight loss, make an important contribution to a better understanding of epigenetic reprogramming in obesity. To investigate the impact of lifestyle in obesity state specific DNA methylation, especially concerning the development of new strategies for prevention and individual therapy, we reviewed 19 most recent human intervention studies. In summary, this review highlights the huge potential of targeted interventions to alter disease-associated epigenetic patterns. However, there is an urgent need for further robust and larger studies to identify the specific DNA methylation biomarkers which influence obesity. |
| first_indexed | 2024-03-12T16:55:07Z |
| format | Article |
| id | doaj.art-e0b7dddb1dcc4881a0d79289bb148767 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-12T16:55:07Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-e0b7dddb1dcc4881a0d79289bb1487672023-08-08T09:51:46ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-08-011410.3389/fendo.2023.11810021181002Implication of DNA methylation during lifestyle mediated weight lossSamantha Aurich0Samantha Aurich1Luise Müller2Peter Kovacs3Peter Kovacs4Maria Keller5Maria Keller6Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, GermanyHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich at the University of Leipzig and University Hospital Leipzig, Leipzig, GermanyMedical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, GermanyMedical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, GermanyDeutsches Zentrum für Diabetesforschung e.V., Neuherberg, GermanyMedical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, GermanyHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich at the University of Leipzig and University Hospital Leipzig, Leipzig, GermanyOver the past 50 years, the number of overweight/obese people increased significantly, making obesity a global public health challenge. Apart from rare monogenic forms, obesity is a multifactorial disease, most likely resulting from a concerted interaction of genetic, epigenetic and environmental factors. Although recent studies opened new avenues in elucidating the complex genetics behind obesity, the biological mechanisms contributing to individual’s risk to become obese are not yet fully understood. Non-genetic factors such as eating behaviour or physical activity are strong contributing factors for the onset of obesity. These factors may interact with genetic predispositions most likely via epigenetic mechanisms. Epigenome-wide association studies or methylome-wide association studies are measuring DNA methylation at single CpGs across thousands of genes and capture associations to obesity phenotypes such as BMI. However, they only represent a snapshot in the complex biological network and cannot distinguish between causes and consequences. Intervention studies are therefore a suitable method to control for confounding factors and to avoid possible sources of bias. In particular, intervention studies documenting changes in obesity-associated epigenetic markers during lifestyle driven weight loss, make an important contribution to a better understanding of epigenetic reprogramming in obesity. To investigate the impact of lifestyle in obesity state specific DNA methylation, especially concerning the development of new strategies for prevention and individual therapy, we reviewed 19 most recent human intervention studies. In summary, this review highlights the huge potential of targeted interventions to alter disease-associated epigenetic patterns. However, there is an urgent need for further robust and larger studies to identify the specific DNA methylation biomarkers which influence obesity.https://www.frontiersin.org/articles/10.3389/fendo.2023.1181002/fulloverweightobesityweight losslifestyleinterventionDNA-methylation |
| spellingShingle | Samantha Aurich Samantha Aurich Luise Müller Peter Kovacs Peter Kovacs Maria Keller Maria Keller Implication of DNA methylation during lifestyle mediated weight loss Frontiers in Endocrinology overweight obesity weight loss lifestyle intervention DNA-methylation |
| title | Implication of DNA methylation during lifestyle mediated weight loss |
| title_full | Implication of DNA methylation during lifestyle mediated weight loss |
| title_fullStr | Implication of DNA methylation during lifestyle mediated weight loss |
| title_full_unstemmed | Implication of DNA methylation during lifestyle mediated weight loss |
| title_short | Implication of DNA methylation during lifestyle mediated weight loss |
| title_sort | implication of dna methylation during lifestyle mediated weight loss |
| topic | overweight obesity weight loss lifestyle intervention DNA-methylation |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1181002/full |
| work_keys_str_mv | AT samanthaaurich implicationofdnamethylationduringlifestylemediatedweightloss AT samanthaaurich implicationofdnamethylationduringlifestylemediatedweightloss AT luisemuller implicationofdnamethylationduringlifestylemediatedweightloss AT peterkovacs implicationofdnamethylationduringlifestylemediatedweightloss AT peterkovacs implicationofdnamethylationduringlifestylemediatedweightloss AT mariakeller implicationofdnamethylationduringlifestylemediatedweightloss AT mariakeller implicationofdnamethylationduringlifestylemediatedweightloss |