Identification and validation of a novel cuproptosis-related stemness signature to predict prognosis and immune landscape in lung adenocarcinoma by integrating single-cell and bulk RNA-sequencing

Identification and validation of a novel cuproptosis-related stemness signature to predict prognosis and immune landscape in lung adenocarcinoma by integrating single-cell and bulk RNA-sequencing

BackgroundCancer stem cells (CSCs) play vital roles in lung adenocarcinoma (LUAD) recurrence, metastasis, and drug resistance. Cuproptosis has provided a novel insight into the treatment of lung CSCs. However, there is a lack of knowledge regarding the cuproptosis-related genes combined with the ste...

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Bibliographic Details
Main Authors: Jia Yang, Kaile Liu, Lu Yang, Junqing Ji, Jingru Qin, Haibin Deng, Zhongqi Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
cuproptosis-related stemness genes (CRSGs)
prognostic signature
immune landscape
single-cell sequencing
lung adenocarcinoma
cancer stem cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1174762/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1174762/full

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