Pioglitazone Synthetic Analogue Ameliorates Streptozotocin-Induced Diabetes Mellitus through Modulation of ACE 2/Angiotensin 1–7 via PI3K/AKT/mTOR Signaling Pathway

Pioglitazone Synthetic Analogue Ameliorates Streptozotocin-Induced Diabetes Mellitus through Modulation of ACE 2/Angiotensin 1–7 via PI3K/AKT/mTOR Signaling Pathway

The renin angiotensin aldosterone system has a localized key regulatory action, especially in liver and body circulation. Furthermore, it accomplishes a significant role in the downregulation of the PI3K/AKT/mTOR signaling pathway that is involved in type II diabetes mellitus pathogenesis. The curre...

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Bibliographic Details
Main Authors: Yasmin M. Ahmed, Mohamed A. Abdelgawad, Khaled Shalaby, Mohammed M. Ghoneim, Asmaa M. AboulMagd, Nada S. Abdelwahab, Hossam M. Hassan, Asmaa M. Othman
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Pharmaceuticals
Subjects:
angiotensin-converting enzyme 2 (ACE 2)
angiotensin 1–7
liver
insulin sensitivity
type 2 diabetes mellitus
phosphoinositide 3-kinases (PI3k)
Online Access:https://www.mdpi.com/1424-8247/15/3/341

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https://www.mdpi.com/1424-8247/15/3/341

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