Age-related changes in tau and autophagy in human brain in the absence of neurodegeneration.

Age-related changes in tau and autophagy in human brain in the absence of neurodegeneration.

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Tau becomes abnormally hyper-phosphorylated and aggregated in tauopathies like Alzheimers disease (AD). As age is the greatest risk factor for developing AD, it is important to understand how tau protein itself, and the pathways implicated in its turnover, change during aging. We investigated age-re...

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Bibliographic Details
Main Authors: Shreyasi Chatterjee, Megan Sealey, Eva Ruiz, Chrysia M Pegasiou, Keeley Brookes, Sam Green, Anna Crisford, Michael Duque-Vasquez, Emma Luckett, Rebecca Robertson, Philippa Richardson, Girish Vajramani, Paul Grundy, Diederik Bulters, Christopher Proud, Mariana Vargas-Caballero, Amritpal Mudher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0262792

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