Assessing the causal role of hypertension on left atrial and left ventricular structure and function: A two-sample Mendelian randomization study
AimThe aim of this study was to investigate whether hypertension may be causally linked to left atrial (LA) and left ventricular (LV) structure and function.Methods and resultsWe performed a two-Mendelian randomization (MR) analysis implementing the results from the FinnGen large-scale, genome-wide...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1006380/full |
| _version_ | 1811255508244365312 |
|---|---|
| author | Yancui Sun Ying Zhang Nan Xu Cheng Bi Xiaojie Liu Wei Song Yinong Jiang |
| author_facet | Yancui Sun Ying Zhang Nan Xu Cheng Bi Xiaojie Liu Wei Song Yinong Jiang |
| author_sort | Yancui Sun |
| collection | DOAJ |
| description | AimThe aim of this study was to investigate whether hypertension may be causally linked to left atrial (LA) and left ventricular (LV) structure and function.Methods and resultsWe performed a two-Mendelian randomization (MR) analysis implementing the results from the FinnGen large-scale, genome-wide association study for hypertension (N = 218,754), and LV (N = 16,923) and LA studies (N = 35,648) by the UK Biobank to identify genetic instruments. The MR analysis was implemented using an inverse-variance weighted (IVW) approach. We identified a positive potential causal relationship between hypertension and indices for the LA maximum (LAmax with causal estimates of 0.126 [95% CI, (0.093 to 0.160)]); LA minimum (LAmin with causal estimates of 0.122 [95% CI, (0.089 to 0.156)]); LV function (causal estimates are LV end-diastolic volume (LVEDV), 0.078 [95% CI, (0.003 to 0.153)]; LV end-systolic volume (LVESV), 0.102 [95% CI, (0.030 to 0.173)]; LV mass (LVM), 0.171 [95% CI, (0.108 to 0.233)]; and LV mass to end-diastolic volume ratio (LVMVR at 0.098 [95% CI, (0.048 to 0.149)], respectively), which was directionally concordant with other robust MR methods. Other than this, we observed a significantly negative causal relationship between hypertension and the LA active emptying fraction (LAAEF), the LA passive emptying fraction (LAPEF), and the LA total emptying fraction (LATEF).ConclusionOur genetic analyses demonstrated a potential causal relationship between hypertension and the left atrium and left ventricle’s structures and functions. |
| first_indexed | 2024-04-12T17:25:50Z |
| format | Article |
| id | doaj.art-e0bb4a4dd305464f94cc3773ad362736 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-12T17:25:50Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-e0bb4a4dd305464f94cc3773ad3627362022-12-22T03:23:19ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-11-01910.3389/fcvm.2022.10063801006380Assessing the causal role of hypertension on left atrial and left ventricular structure and function: A two-sample Mendelian randomization studyYancui Sun0Ying Zhang1Nan Xu2Cheng Bi3Xiaojie Liu4Wei Song5Yinong Jiang6Department of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, ChinaDepartment of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, ChinaSchool of Basic Medical Sciences, Henan University, Kaifeng, Henan, ChinaDepartment of Cardiology, Tieling Central Hospital, Tieling, Liaoning, ChinaDepartment of Cardiology, The Liaoyu Hospital of Dalian, Dalian, Liaoning, ChinaDepartment of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, ChinaDepartment of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, ChinaAimThe aim of this study was to investigate whether hypertension may be causally linked to left atrial (LA) and left ventricular (LV) structure and function.Methods and resultsWe performed a two-Mendelian randomization (MR) analysis implementing the results from the FinnGen large-scale, genome-wide association study for hypertension (N = 218,754), and LV (N = 16,923) and LA studies (N = 35,648) by the UK Biobank to identify genetic instruments. The MR analysis was implemented using an inverse-variance weighted (IVW) approach. We identified a positive potential causal relationship between hypertension and indices for the LA maximum (LAmax with causal estimates of 0.126 [95% CI, (0.093 to 0.160)]); LA minimum (LAmin with causal estimates of 0.122 [95% CI, (0.089 to 0.156)]); LV function (causal estimates are LV end-diastolic volume (LVEDV), 0.078 [95% CI, (0.003 to 0.153)]; LV end-systolic volume (LVESV), 0.102 [95% CI, (0.030 to 0.173)]; LV mass (LVM), 0.171 [95% CI, (0.108 to 0.233)]; and LV mass to end-diastolic volume ratio (LVMVR at 0.098 [95% CI, (0.048 to 0.149)], respectively), which was directionally concordant with other robust MR methods. Other than this, we observed a significantly negative causal relationship between hypertension and the LA active emptying fraction (LAAEF), the LA passive emptying fraction (LAPEF), and the LA total emptying fraction (LATEF).ConclusionOur genetic analyses demonstrated a potential causal relationship between hypertension and the left atrium and left ventricle’s structures and functions.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1006380/fullleft atrialleft ventricularMendelian randomizationhypertensiongenetics |
| spellingShingle | Yancui Sun Ying Zhang Nan Xu Cheng Bi Xiaojie Liu Wei Song Yinong Jiang Assessing the causal role of hypertension on left atrial and left ventricular structure and function: A two-sample Mendelian randomization study Frontiers in Cardiovascular Medicine left atrial left ventricular Mendelian randomization hypertension genetics |
| title | Assessing the causal role of hypertension on left atrial and left ventricular structure and function: A two-sample Mendelian randomization study |
| title_full | Assessing the causal role of hypertension on left atrial and left ventricular structure and function: A two-sample Mendelian randomization study |
| title_fullStr | Assessing the causal role of hypertension on left atrial and left ventricular structure and function: A two-sample Mendelian randomization study |
| title_full_unstemmed | Assessing the causal role of hypertension on left atrial and left ventricular structure and function: A two-sample Mendelian randomization study |
| title_short | Assessing the causal role of hypertension on left atrial and left ventricular structure and function: A two-sample Mendelian randomization study |
| title_sort | assessing the causal role of hypertension on left atrial and left ventricular structure and function a two sample mendelian randomization study |
| topic | left atrial left ventricular Mendelian randomization hypertension genetics |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1006380/full |
| work_keys_str_mv | AT yancuisun assessingthecausalroleofhypertensiononleftatrialandleftventricularstructureandfunctionatwosamplemendelianrandomizationstudy AT yingzhang assessingthecausalroleofhypertensiononleftatrialandleftventricularstructureandfunctionatwosamplemendelianrandomizationstudy AT nanxu assessingthecausalroleofhypertensiononleftatrialandleftventricularstructureandfunctionatwosamplemendelianrandomizationstudy AT chengbi assessingthecausalroleofhypertensiononleftatrialandleftventricularstructureandfunctionatwosamplemendelianrandomizationstudy AT xiaojieliu assessingthecausalroleofhypertensiononleftatrialandleftventricularstructureandfunctionatwosamplemendelianrandomizationstudy AT weisong assessingthecausalroleofhypertensiononleftatrialandleftventricularstructureandfunctionatwosamplemendelianrandomizationstudy AT yinongjiang assessingthecausalroleofhypertensiononleftatrialandleftventricularstructureandfunctionatwosamplemendelianrandomizationstudy |