N‐terminal brain natriuretic peptide, cardiac troponin‐I, and point‐of‐care ultrasound in dogs with cardiac and noncardiac causes of nonhemorrhagic ascites
Abstract Background Nonhemorrhagic ascites (NHA) can be caused by cardiac diseases (cNHA) and noncardiac diseases (ncNHA). N‐terminal brain natriuretic peptide (NT‐proBNP), cardiac troponin‐I (cTnI), and point‐of‐care ultrasound (POCUS) may differentiate between cNHA and ncNHA. Hypothesis/Objectives...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-05-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.16702 |
| _version_ | 1827938089283092480 |
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| author | Alice G. N. Morey Kenneth E. Lamb James J. Karnia Kelly E. Wiggen Bridget M. Lyons Laura A. Nafe Stacey B. Leach |
| author_facet | Alice G. N. Morey Kenneth E. Lamb James J. Karnia Kelly E. Wiggen Bridget M. Lyons Laura A. Nafe Stacey B. Leach |
| author_sort | Alice G. N. Morey |
| collection | DOAJ |
| description | Abstract Background Nonhemorrhagic ascites (NHA) can be caused by cardiac diseases (cNHA) and noncardiac diseases (ncNHA). N‐terminal brain natriuretic peptide (NT‐proBNP), cardiac troponin‐I (cTnI), and point‐of‐care ultrasound (POCUS) may differentiate between cNHA and ncNHA. Hypothesis/Objectives We compared NT‐proBNP and cTnI concentrations as well as POCUS findings in dogs presented with cNHA and ncNHA. Animals Dogs (n = 60) were enrolled based on identification of NHA with an effusion packed cell volume < 10%. Methods Blood samples were collected and POCUS was performed on all dogs. Dogs were diagnosed with cNHA (n = 28) or ncNHA (n = 32) based on echocardiography. The cNHA group was subdivided into cardiac non‐pericardial disease (n = 17) and pericardial disease (n = 11). Results The NT‐proBNP concentration (median; range pmol/L) was significantly higher in the cNHA group (4510; 250‐10 000) compared to the ncNHA group (739.5; 250‐10 000; P = .01), with a sensitivity of 53.8% and specificity of 85.7% using a cut‐off of 4092 pmol/L. The NT‐proBNP concentrations were significantly higher in the cardiac non‐pericardial disease group (8339; 282‐10 000) compared with the pericardial disease group (692.5; 250‐4928; P = .002). A significant difference in cTnI concentration (median; range ng/L) between the cNHA group (300; 23‐112 612) and ncNHA group (181; 17‐37 549) was not detected (P = .41). A significantly higher number of dogs had hepatic venous and caudal vena cava distension in the cNHA group compared to the ncNHA group, respectively (18/28 vs 3/29, P < .0001 and 13/27 vs 2/29, P < .001). Gall bladder wall edema was not significantly different between groups (4/28 vs 3/29, P = .74). Conclusions and Clinical Importance NT‐proBNP concentration and POCUS help distinguish between cNHA and ncNHA. |
| first_indexed | 2024-03-13T08:34:23Z |
| format | Article |
| id | doaj.art-e0bc329a2fe94e17951cef40a8d22351 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-03-13T08:34:23Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-e0bc329a2fe94e17951cef40a8d223512023-05-31T01:33:58ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762023-05-0137390090910.1111/jvim.16702N‐terminal brain natriuretic peptide, cardiac troponin‐I, and point‐of‐care ultrasound in dogs with cardiac and noncardiac causes of nonhemorrhagic ascitesAlice G. N. Morey0Kenneth E. Lamb1James J. Karnia2Kelly E. Wiggen3Bridget M. Lyons4Laura A. Nafe5Stacey B. Leach6Department of Veterinary Medicine Surgery, College of Veterinary Medicine University of Missouri Columbia Missouri USALamb Consulting LLC West St. Paul Minnesota USADepartment of Veterinary Medicine Surgery, College of Veterinary Medicine University of Missouri Columbia Missouri USADepartment of Veterinary Medicine Surgery, College of Veterinary Medicine University of Missouri Columbia Missouri USADepartment of Veterinary Medicine Surgery, College of Veterinary Medicine University of Missouri Columbia Missouri USADepartment of Veterinary Medicine Surgery, College of Veterinary Medicine University of Missouri Columbia Missouri USADepartment of Veterinary Medicine Surgery, College of Veterinary Medicine University of Missouri Columbia Missouri USAAbstract Background Nonhemorrhagic ascites (NHA) can be caused by cardiac diseases (cNHA) and noncardiac diseases (ncNHA). N‐terminal brain natriuretic peptide (NT‐proBNP), cardiac troponin‐I (cTnI), and point‐of‐care ultrasound (POCUS) may differentiate between cNHA and ncNHA. Hypothesis/Objectives We compared NT‐proBNP and cTnI concentrations as well as POCUS findings in dogs presented with cNHA and ncNHA. Animals Dogs (n = 60) were enrolled based on identification of NHA with an effusion packed cell volume < 10%. Methods Blood samples were collected and POCUS was performed on all dogs. Dogs were diagnosed with cNHA (n = 28) or ncNHA (n = 32) based on echocardiography. The cNHA group was subdivided into cardiac non‐pericardial disease (n = 17) and pericardial disease (n = 11). Results The NT‐proBNP concentration (median; range pmol/L) was significantly higher in the cNHA group (4510; 250‐10 000) compared to the ncNHA group (739.5; 250‐10 000; P = .01), with a sensitivity of 53.8% and specificity of 85.7% using a cut‐off of 4092 pmol/L. The NT‐proBNP concentrations were significantly higher in the cardiac non‐pericardial disease group (8339; 282‐10 000) compared with the pericardial disease group (692.5; 250‐4928; P = .002). A significant difference in cTnI concentration (median; range ng/L) between the cNHA group (300; 23‐112 612) and ncNHA group (181; 17‐37 549) was not detected (P = .41). A significantly higher number of dogs had hepatic venous and caudal vena cava distension in the cNHA group compared to the ncNHA group, respectively (18/28 vs 3/29, P < .0001 and 13/27 vs 2/29, P < .001). Gall bladder wall edema was not significantly different between groups (4/28 vs 3/29, P = .74). Conclusions and Clinical Importance NT‐proBNP concentration and POCUS help distinguish between cNHA and ncNHA.https://doi.org/10.1111/jvim.16702BNPcaninecongestive heart failureechocardiography |
| spellingShingle | Alice G. N. Morey Kenneth E. Lamb James J. Karnia Kelly E. Wiggen Bridget M. Lyons Laura A. Nafe Stacey B. Leach N‐terminal brain natriuretic peptide, cardiac troponin‐I, and point‐of‐care ultrasound in dogs with cardiac and noncardiac causes of nonhemorrhagic ascites Journal of Veterinary Internal Medicine BNP canine congestive heart failure echocardiography |
| title | N‐terminal brain natriuretic peptide, cardiac troponin‐I, and point‐of‐care ultrasound in dogs with cardiac and noncardiac causes of nonhemorrhagic ascites |
| title_full | N‐terminal brain natriuretic peptide, cardiac troponin‐I, and point‐of‐care ultrasound in dogs with cardiac and noncardiac causes of nonhemorrhagic ascites |
| title_fullStr | N‐terminal brain natriuretic peptide, cardiac troponin‐I, and point‐of‐care ultrasound in dogs with cardiac and noncardiac causes of nonhemorrhagic ascites |
| title_full_unstemmed | N‐terminal brain natriuretic peptide, cardiac troponin‐I, and point‐of‐care ultrasound in dogs with cardiac and noncardiac causes of nonhemorrhagic ascites |
| title_short | N‐terminal brain natriuretic peptide, cardiac troponin‐I, and point‐of‐care ultrasound in dogs with cardiac and noncardiac causes of nonhemorrhagic ascites |
| title_sort | n terminal brain natriuretic peptide cardiac troponin i and point of care ultrasound in dogs with cardiac and noncardiac causes of nonhemorrhagic ascites |
| topic | BNP canine congestive heart failure echocardiography |
| url | https://doi.org/10.1111/jvim.16702 |
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