Neuromyelitis Optica Spectrum Disorder: From Basic Research to Clinical Perspectives
Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system characterized by relapses and autoimmunity caused by antibodies against the astrocyte water channel protein aquaporin-4. Over the past decade, there have been significant advances in the biologic...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/14/7908 |
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| author | Tzu-Lun Huang Jia-Kang Wang Pei-Yao Chang Yung-Ray Hsu Cheng-Hung Lin Kung-Hung Lin Rong-Kung Tsai |
| author_facet | Tzu-Lun Huang Jia-Kang Wang Pei-Yao Chang Yung-Ray Hsu Cheng-Hung Lin Kung-Hung Lin Rong-Kung Tsai |
| author_sort | Tzu-Lun Huang |
| collection | DOAJ |
| description | Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system characterized by relapses and autoimmunity caused by antibodies against the astrocyte water channel protein aquaporin-4. Over the past decade, there have been significant advances in the biologic knowledge of NMOSD, which resulted in the IDENTIFICATION of variable disease phenotypes, biomarkers, and complex inflammatory cascades involved in disease pathogenesis. Ongoing clinical trials are looking at new treatments targeting NMOSD relapses. This review aims to provide an update on recent studies regarding issues related to NMOSD, including the pathophysiology of the disease, the potential use of serum and cerebrospinal fluid cytokines as disease biomarkers, the clinical utilization of ocular coherence tomography, and the comparison of different animal models of NMOSD. |
| first_indexed | 2024-03-09T03:20:53Z |
| format | Article |
| id | doaj.art-e0bd50b4369949789eb9a496845fc077 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T03:20:53Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e0bd50b4369949789eb9a496845fc0772023-12-03T15:10:17ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012314790810.3390/ijms23147908Neuromyelitis Optica Spectrum Disorder: From Basic Research to Clinical PerspectivesTzu-Lun Huang0Jia-Kang Wang1Pei-Yao Chang2Yung-Ray Hsu3Cheng-Hung Lin4Kung-Hung Lin5Rong-Kung Tsai6Department of Ophthalmology, Far Eastern Memorial Hospital, Banqiao Dist., New Taipei City 220, TaiwanDepartment of Ophthalmology, Far Eastern Memorial Hospital, Banqiao Dist., New Taipei City 220, TaiwanDepartment of Ophthalmology, Far Eastern Memorial Hospital, Banqiao Dist., New Taipei City 220, TaiwanDepartment of Ophthalmology, Far Eastern Memorial Hospital, Banqiao Dist., New Taipei City 220, TaiwanDepartment of Electrical Engineering, Yuan Ze University, Chung-Li, Taoyuan 320, TaiwanDepartment of Neurology, Taiwan Adventist Hospital, Taipei City 105, TaiwanInstitute of Eye Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, 707 Sec. 3 Chung-Yung Road, Hualien 970, TaiwanNeuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system characterized by relapses and autoimmunity caused by antibodies against the astrocyte water channel protein aquaporin-4. Over the past decade, there have been significant advances in the biologic knowledge of NMOSD, which resulted in the IDENTIFICATION of variable disease phenotypes, biomarkers, and complex inflammatory cascades involved in disease pathogenesis. Ongoing clinical trials are looking at new treatments targeting NMOSD relapses. This review aims to provide an update on recent studies regarding issues related to NMOSD, including the pathophysiology of the disease, the potential use of serum and cerebrospinal fluid cytokines as disease biomarkers, the clinical utilization of ocular coherence tomography, and the comparison of different animal models of NMOSD.https://www.mdpi.com/1422-0067/23/14/7908neuromyelitis optica spectrum diseaseaquaporin-4myelin oligodendrocyte glycoproteinocular coherence tomographycomplementmicrocystic macular degeneration |
| spellingShingle | Tzu-Lun Huang Jia-Kang Wang Pei-Yao Chang Yung-Ray Hsu Cheng-Hung Lin Kung-Hung Lin Rong-Kung Tsai Neuromyelitis Optica Spectrum Disorder: From Basic Research to Clinical Perspectives International Journal of Molecular Sciences neuromyelitis optica spectrum disease aquaporin-4 myelin oligodendrocyte glycoprotein ocular coherence tomography complement microcystic macular degeneration |
| title | Neuromyelitis Optica Spectrum Disorder: From Basic Research to Clinical Perspectives |
| title_full | Neuromyelitis Optica Spectrum Disorder: From Basic Research to Clinical Perspectives |
| title_fullStr | Neuromyelitis Optica Spectrum Disorder: From Basic Research to Clinical Perspectives |
| title_full_unstemmed | Neuromyelitis Optica Spectrum Disorder: From Basic Research to Clinical Perspectives |
| title_short | Neuromyelitis Optica Spectrum Disorder: From Basic Research to Clinical Perspectives |
| title_sort | neuromyelitis optica spectrum disorder from basic research to clinical perspectives |
| topic | neuromyelitis optica spectrum disease aquaporin-4 myelin oligodendrocyte glycoprotein ocular coherence tomography complement microcystic macular degeneration |
| url | https://www.mdpi.com/1422-0067/23/14/7908 |
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