Adenoviral transfer of the heme oxygenase-1 gene protects striatal astrocytes from heme-mediated oxidative injury

Adenoviral transfer of the heme oxygenase-1 gene protects striatal astrocytes from heme-mediated oxidative injury

Heme oxygenase-1 (HO-1) is induced in the CNS after hemorrhage, and may have an effect on injury to surrounding tissue. Hemin, the preferred substrate of HO, is a neurotoxin that is present in intracranial hematomas. In a prior study, we observed that HO inhibitors increased the vulnerability of cul...

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Bibliographic Details
Main Authors: Zhi-Ping Teng, Jing Chen, Lee-Young Chau, Nicholas Galunic, Raymond F. Regan
Format: Article
Language:English
Published: Elsevier 2004-11-01
Series:Neurobiology of Disease
Subjects:
Free radical
Hemoglobin
Hemorrhage
Iron
Mouse
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104001640

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