Lycopene, amaranth, and sorghum red pigments counteract obesity and modulate the gut microbiota in high-fat diet fed C57BL/6 mice
The present study investigated the anti-obesity effects of lycopene (LC), amaranth (AR), and sorghum red (SR) in high-fat diet-induced C57BL/6J mice. Compared with untreated mice on a high-fat diet for 12 weeks, LC, AR, and SR reduced the body weight by 17.9%, 23.5%, and 26.5%, respectively. They ma...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-09-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619303615 |
| _version_ | 1828933293059342336 |
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| author | Tao Wu Yufang Gao Junyu Hao Jinjin Yin Wen Li Jieting Geng Rui Liu Wenjie Sui Min Zhang |
| author_facet | Tao Wu Yufang Gao Junyu Hao Jinjin Yin Wen Li Jieting Geng Rui Liu Wenjie Sui Min Zhang |
| author_sort | Tao Wu |
| collection | DOAJ |
| description | The present study investigated the anti-obesity effects of lycopene (LC), amaranth (AR), and sorghum red (SR) in high-fat diet-induced C57BL/6J mice. Compared with untreated mice on a high-fat diet for 12 weeks, LC, AR, and SR reduced the body weight by 17.9%, 23.5%, and 26.5%, respectively. They markedly reversed glucose tolerance and the serum levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol, observably improved the liver profiles of TG and TC, and effectively ameliorated lipid metabolism. After the administration of LC, AR, and SR, the intestinal microbial environment improved in the sense that bacterial diversity increased and Clostridium abundance decreased. LC and SR promoted the proliferation of Akkermansia, whereas AR and SR impeded the proliferation of Prevotella. Furthermore, LC, AR, and SR reduced the TMAO level. In conclusion, LC, AR, and SR may protect against high-diet induced obesity and modulate the gut microbiota of mice. |
| first_indexed | 2024-12-14T01:14:07Z |
| format | Article |
| id | doaj.art-e0c1181f55674ccf9702b8f547241bf5 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T01:14:07Z |
| publishDate | 2019-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-e0c1181f55674ccf9702b8f547241bf52022-12-21T23:22:39ZengElsevierJournal of Functional Foods1756-46462019-09-0160Lycopene, amaranth, and sorghum red pigments counteract obesity and modulate the gut microbiota in high-fat diet fed C57BL/6 miceTao Wu0Yufang Gao1Junyu Hao2Jinjin Yin3Wen Li4Jieting Geng5Rui Liu6Wenjie Sui7Min Zhang8State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, Tianjin 300457, China; Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology & Business University, Beijing, ChinaState Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, Tianjin 300457, ChinaState Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, Tianjin 300457, ChinaState Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, Tianjin 300457, China; Corresponding authors.State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, Tianjin 300457, ChinaDepartment of Food Science and Technology, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato-ku, Tokyo 108-8477, JapanState Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, Tianjin 300457, ChinaState Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, Tianjin 300457, ChinaState Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, Tianjin 300457, China; Corresponding authors.The present study investigated the anti-obesity effects of lycopene (LC), amaranth (AR), and sorghum red (SR) in high-fat diet-induced C57BL/6J mice. Compared with untreated mice on a high-fat diet for 12 weeks, LC, AR, and SR reduced the body weight by 17.9%, 23.5%, and 26.5%, respectively. They markedly reversed glucose tolerance and the serum levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol, observably improved the liver profiles of TG and TC, and effectively ameliorated lipid metabolism. After the administration of LC, AR, and SR, the intestinal microbial environment improved in the sense that bacterial diversity increased and Clostridium abundance decreased. LC and SR promoted the proliferation of Akkermansia, whereas AR and SR impeded the proliferation of Prevotella. Furthermore, LC, AR, and SR reduced the TMAO level. In conclusion, LC, AR, and SR may protect against high-diet induced obesity and modulate the gut microbiota of mice.http://www.sciencedirect.com/science/article/pii/S1756464619303615Natural pigmentHigh-fat dietObesityGut microbiotaTrimethylamine N-oxide |
| spellingShingle | Tao Wu Yufang Gao Junyu Hao Jinjin Yin Wen Li Jieting Geng Rui Liu Wenjie Sui Min Zhang Lycopene, amaranth, and sorghum red pigments counteract obesity and modulate the gut microbiota in high-fat diet fed C57BL/6 mice Journal of Functional Foods Natural pigment High-fat diet Obesity Gut microbiota Trimethylamine N-oxide |
| title | Lycopene, amaranth, and sorghum red pigments counteract obesity and modulate the gut microbiota in high-fat diet fed C57BL/6 mice |
| title_full | Lycopene, amaranth, and sorghum red pigments counteract obesity and modulate the gut microbiota in high-fat diet fed C57BL/6 mice |
| title_fullStr | Lycopene, amaranth, and sorghum red pigments counteract obesity and modulate the gut microbiota in high-fat diet fed C57BL/6 mice |
| title_full_unstemmed | Lycopene, amaranth, and sorghum red pigments counteract obesity and modulate the gut microbiota in high-fat diet fed C57BL/6 mice |
| title_short | Lycopene, amaranth, and sorghum red pigments counteract obesity and modulate the gut microbiota in high-fat diet fed C57BL/6 mice |
| title_sort | lycopene amaranth and sorghum red pigments counteract obesity and modulate the gut microbiota in high fat diet fed c57bl 6 mice |
| topic | Natural pigment High-fat diet Obesity Gut microbiota Trimethylamine N-oxide |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619303615 |
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