Changes of brain activation and networks in patients with spinal cord injury based on functional near⁃infrared spectroscopy
Objective To investigate the changes of brain activation and brain network connectivity in patients with spinal cord injury (SCI). Methods A total of 20 patients with SCI were selected from Qilu Hospital of Shandong University from January to October 2021, including 8 patients with simple lower extr...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2022-11-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/2589 |
| _version_ | 1811178212240130048 |
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| author | SUN Zhi⁃fang LI Xing⁃lou SUN Wei⁃zhen LUO Mei⁃ling WANG Yong⁃hui |
| author_facet | SUN Zhi⁃fang LI Xing⁃lou SUN Wei⁃zhen LUO Mei⁃ling WANG Yong⁃hui |
| author_sort | SUN Zhi⁃fang |
| collection | DOAJ |
| description | Objective To investigate the changes of brain activation and brain network connectivity in patients with spinal cord injury (SCI). Methods A total of 20 patients with SCI were selected from Qilu Hospital of Shandong University from January to October 2021, including 8 patients with simple lower extremity involvement (paraplegia group) and 12 patients with all limbs involvement (tetraplegia group), and 10 healthy controls with matched baseline data with the SCI group were included in the same period. Functional near⁃infrared spectroscopy (fNIRS) was used to collect the data of cerebral oxyhemoglobin (HbO2) in the bilateral prefrontal lobe (LPFC/RPFC), motor cortex (LMC/RMC) and occipital lobe (LOL/ROL). The resting HbO2 β values was calculated by generalized linear model to evaluate the activation degree of the cerebral cortex covered by different detection channels, the correlation between HbO2 β values was calculated by Pearson correlation analysis and partial correlation to analysis different detection channels [partial correlation coefficient (r) was defined as functional connectivity strength] to evaluate the functional connectivity of the brain network. Results 1) Degree of brain activation: compared with the control group, the HbO2 β values corresponding to channel 2 (t=⁃2.482, P=0.020), channel 8 (t=⁃3.315, P=0.003) and channel 16 (t=⁃2.738, P=0.011) was increased in the tetraplegia group, while the HbO2 β value corresponding to channel 25 was decreased (t=2.104, P=0.045), and the HbO2 β value of channel 8 was increased (t=⁃2.475, P=0.020) in paraplegia group. Compared with the tetraplegia group, the HbO2 β values in channel 17 (t=2.552, P=0.017) and channel 25 (t=2.342, P=0.027) were increased in the paraplegia group. The value of HbO2 β in the left prefrontal lobe of tetraplegia group was significantly higher than that of control group (t=2.652, P=0.013). 2) The number of functional connections between different channels and cerebral cortex: the proportion of channels related to motor cortex in different groups was 94.12% in the paraplegia group (32/34), 82.76% in the tetraplegia group (24/29), and only 74.36% in the control group (29/39). 3) Functional connectivity strength in the brain: compared with the control group, the functional connectivity strength in the right motor area was weakened in both the paraplegia group (t=4.572, P=0.000) and the tetraplegia group (t=4.822, P=0.000). Conclusions There are abnormalities in resting brain activation and functional connectivity of brain network after SCI, which are manifested as local enhancement of spontaneous neural activity in some brain regions and abnormal functional connectivity in cerebral cortices and brain regions. |
| first_indexed | 2024-04-11T06:15:47Z |
| format | Article |
| id | doaj.art-e0c159e1dd00463199dee9347cc82d02 |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-04-11T06:15:47Z |
| publishDate | 2022-11-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-e0c159e1dd00463199dee9347cc82d022022-12-22T04:41:04ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312022-11-01221195696410.3969/j.issn.1672⁃6731.2022.11.007Changes of brain activation and networks in patients with spinal cord injury based on functional near⁃infrared spectroscopySUN Zhi⁃fang0LI Xing⁃lou1 SUN Wei⁃zhen2LUO Mei⁃ling3 WANG Yong⁃hui4Rehabilitation Center, Qilu Hospital of Shandong UniversityRehabilitation Center, Qilu Hospital of Shandong UniversityRehabilitation Center, Qilu Hospital of Shandong UniversityRehabilitation Center, Qilu Hospital of Shandong UniversityRehabilitation Center, Qilu Hospital of Shandong UniversityObjective To investigate the changes of brain activation and brain network connectivity in patients with spinal cord injury (SCI). Methods A total of 20 patients with SCI were selected from Qilu Hospital of Shandong University from January to October 2021, including 8 patients with simple lower extremity involvement (paraplegia group) and 12 patients with all limbs involvement (tetraplegia group), and 10 healthy controls with matched baseline data with the SCI group were included in the same period. Functional near⁃infrared spectroscopy (fNIRS) was used to collect the data of cerebral oxyhemoglobin (HbO2) in the bilateral prefrontal lobe (LPFC/RPFC), motor cortex (LMC/RMC) and occipital lobe (LOL/ROL). The resting HbO2 β values was calculated by generalized linear model to evaluate the activation degree of the cerebral cortex covered by different detection channels, the correlation between HbO2 β values was calculated by Pearson correlation analysis and partial correlation to analysis different detection channels [partial correlation coefficient (r) was defined as functional connectivity strength] to evaluate the functional connectivity of the brain network. Results 1) Degree of brain activation: compared with the control group, the HbO2 β values corresponding to channel 2 (t=⁃2.482, P=0.020), channel 8 (t=⁃3.315, P=0.003) and channel 16 (t=⁃2.738, P=0.011) was increased in the tetraplegia group, while the HbO2 β value corresponding to channel 25 was decreased (t=2.104, P=0.045), and the HbO2 β value of channel 8 was increased (t=⁃2.475, P=0.020) in paraplegia group. Compared with the tetraplegia group, the HbO2 β values in channel 17 (t=2.552, P=0.017) and channel 25 (t=2.342, P=0.027) were increased in the paraplegia group. The value of HbO2 β in the left prefrontal lobe of tetraplegia group was significantly higher than that of control group (t=2.652, P=0.013). 2) The number of functional connections between different channels and cerebral cortex: the proportion of channels related to motor cortex in different groups was 94.12% in the paraplegia group (32/34), 82.76% in the tetraplegia group (24/29), and only 74.36% in the control group (29/39). 3) Functional connectivity strength in the brain: compared with the control group, the functional connectivity strength in the right motor area was weakened in both the paraplegia group (t=4.572, P=0.000) and the tetraplegia group (t=4.822, P=0.000). Conclusions There are abnormalities in resting brain activation and functional connectivity of brain network after SCI, which are manifested as local enhancement of spontaneous neural activity in some brain regions and abnormal functional connectivity in cerebral cortices and brain regions.http://www.cjcnn.org/index.php/cjcnn/article/view/2589spinal cord injuriesspectroscopy near⁃infraredoxyhemoglobinsfunctional connectivity (not in mesh) |
| spellingShingle | SUN Zhi⁃fang LI Xing⁃lou SUN Wei⁃zhen LUO Mei⁃ling WANG Yong⁃hui Changes of brain activation and networks in patients with spinal cord injury based on functional near⁃infrared spectroscopy Chinese Journal of Contemporary Neurology and Neurosurgery spinal cord injuries spectroscopy near⁃infrared oxyhemoglobins functional connectivity (not in mesh) |
| title | Changes of brain activation and networks in patients with spinal cord injury based on functional near⁃infrared spectroscopy |
| title_full | Changes of brain activation and networks in patients with spinal cord injury based on functional near⁃infrared spectroscopy |
| title_fullStr | Changes of brain activation and networks in patients with spinal cord injury based on functional near⁃infrared spectroscopy |
| title_full_unstemmed | Changes of brain activation and networks in patients with spinal cord injury based on functional near⁃infrared spectroscopy |
| title_short | Changes of brain activation and networks in patients with spinal cord injury based on functional near⁃infrared spectroscopy |
| title_sort | changes of brain activation and networks in patients with spinal cord injury based on functional near⁃infrared spectroscopy |
| topic | spinal cord injuries spectroscopy near⁃infrared oxyhemoglobins functional connectivity (not in mesh) |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/2589 |
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