Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression
Persistent diabetic complications despite controlled blood glucose levels, known as hyperglycemic memory, remain a poorly understood phenomenon in diabetic kidney disease. Here the authors identify senescence-associated gene p21 as a regulator of hyperglycemic memory, the suppression of which improv...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32477-9 |
| _version_ | 1811188759817879552 |
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| author | Moh’d Mohanad Al-Dabet Khurrum Shahzad Ahmed Elwakiel Alba Sulaj Stefan Kopf Fabian Bock Ihsan Gadi Silke Zimmermann Rajiv Rana Shruthi Krishnan Dheerendra Gupta Jayakumar Manoharan Sameen Fatima Sumra Nazir Constantin Schwab Ronny Baber Markus Scholz Robert Geffers Peter Rene Mertens Peter P. Nawroth John H. Griffin Maria Keller Chris Dockendorff Shrey Kohli Berend Isermann |
| author_facet | Moh’d Mohanad Al-Dabet Khurrum Shahzad Ahmed Elwakiel Alba Sulaj Stefan Kopf Fabian Bock Ihsan Gadi Silke Zimmermann Rajiv Rana Shruthi Krishnan Dheerendra Gupta Jayakumar Manoharan Sameen Fatima Sumra Nazir Constantin Schwab Ronny Baber Markus Scholz Robert Geffers Peter Rene Mertens Peter P. Nawroth John H. Griffin Maria Keller Chris Dockendorff Shrey Kohli Berend Isermann |
| author_sort | Moh’d Mohanad Al-Dabet |
| collection | DOAJ |
| description | Persistent diabetic complications despite controlled blood glucose levels, known as hyperglycemic memory, remain a poorly understood phenomenon in diabetic kidney disease. Here the authors identify senescence-associated gene p21 as a regulator of hyperglycemic memory, the suppression of which improves hyperglycemic memory and renal function. |
| first_indexed | 2024-04-11T14:23:48Z |
| format | Article |
| id | doaj.art-e0c24968fbe44886ac4eb5d91d955ed8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T14:23:48Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e0c24968fbe44886ac4eb5d91d955ed82022-12-22T04:18:56ZengNature PortfolioNature Communications2041-17232022-08-0113111710.1038/s41467-022-32477-9Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expressionMoh’d Mohanad Al-Dabet0Khurrum Shahzad1Ahmed Elwakiel2Alba Sulaj3Stefan Kopf4Fabian Bock5Ihsan Gadi6Silke Zimmermann7Rajiv Rana8Shruthi Krishnan9Dheerendra Gupta10Jayakumar Manoharan11Sameen Fatima12Sumra Nazir13Constantin Schwab14Ronny Baber15Markus Scholz16Robert Geffers17Peter Rene Mertens18Peter P. Nawroth19John H. Griffin20Maria Keller21Chris Dockendorff22Shrey Kohli23Berend Isermann24Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig UniversityInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig UniversityInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig UniversityInternal Medicine I and Clinical Chemistry, German Diabetes Center (DZD), University of HeidelbergInternal Medicine I and Clinical Chemistry, German Diabetes Center (DZD), University of HeidelbergInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig UniversityInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig UniversityInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig UniversityInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig UniversityInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig UniversityInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig UniversityInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig UniversityInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig UniversityInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig UniversityInstitute of Pathology, University of HeidelbergInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig UniversityInstitute for Medical Informatics, Statistics and Epidemiology, Leipzig UniversityGenome Analytics, Helmholtz Centre for Infection ResearchClinic of Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke UniversityInternal Medicine I and Clinical Chemistry, German Diabetes Center (DZD), University of HeidelbergDepartment of Molecular Medicine, The Scripps Research InstituteHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Center Munich at the University of Leipzig and University Hospital LeipzigDepartment of Chemistry, Marquette UniversityInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig UniversityInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Universitätsklinikum Leipzig, Leipzig UniversityPersistent diabetic complications despite controlled blood glucose levels, known as hyperglycemic memory, remain a poorly understood phenomenon in diabetic kidney disease. Here the authors identify senescence-associated gene p21 as a regulator of hyperglycemic memory, the suppression of which improves hyperglycemic memory and renal function.https://doi.org/10.1038/s41467-022-32477-9 |
| spellingShingle | Moh’d Mohanad Al-Dabet Khurrum Shahzad Ahmed Elwakiel Alba Sulaj Stefan Kopf Fabian Bock Ihsan Gadi Silke Zimmermann Rajiv Rana Shruthi Krishnan Dheerendra Gupta Jayakumar Manoharan Sameen Fatima Sumra Nazir Constantin Schwab Ronny Baber Markus Scholz Robert Geffers Peter Rene Mertens Peter P. Nawroth John H. Griffin Maria Keller Chris Dockendorff Shrey Kohli Berend Isermann Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression Nature Communications |
| title | Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression |
| title_full | Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression |
| title_fullStr | Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression |
| title_full_unstemmed | Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression |
| title_short | Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression |
| title_sort | reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression |
| url | https://doi.org/10.1038/s41467-022-32477-9 |
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