Potential Role of Vaginal Microbiota in Ovarian Cancer Carcinogenesis, Progression and Treatment
Ovarian cancer represents one of the most challenging gynecologic cancers which still has numerous unknowns on the underlying pathogenesis. In addition to the verified contributors such as genomic predisposition and medical history in the carcinogenesis, emerging evidence points out the potential ro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/3/948 |
| _version_ | 1797609530666778624 |
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| author | Xiumiao Zhao Zhaoxia Liu Tingtao Chen |
| author_facet | Xiumiao Zhao Zhaoxia Liu Tingtao Chen |
| author_sort | Xiumiao Zhao |
| collection | DOAJ |
| description | Ovarian cancer represents one of the most challenging gynecologic cancers which still has numerous unknowns on the underlying pathogenesis. In addition to the verified contributors such as genomic predisposition and medical history in the carcinogenesis, emerging evidence points out the potential role of vaginal microbiota in ovarian cancer. Recent studies have underlined the presence of vaginal microbial dysbiosis in cancer cases. Increasing research also indicates the potential correlations between vaginal microbes and cancer carcinogenesis, progression and treatment. Currently, compared with other gynecologic cancers, reports on the roles of vaginal microbiota in ovarian cancer remain scarce and fragmentary. Therefore, in this review, we summarize the roles of vaginal microbiota in various gynecologic diseases, particularly focusing on the potential mechanisms and possible applications of vaginal microbiota in ovarian cancer, giving insight into the involvement of vaginal microbiota in gynecologic cancer treatment. |
| first_indexed | 2024-03-11T06:02:43Z |
| format | Article |
| id | doaj.art-e0c25b199a344cb380a8929319e0a2e0 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T06:02:43Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-e0c25b199a344cb380a8929319e0a2e02023-11-17T13:16:39ZengMDPI AGPharmaceutics1999-49232023-03-0115394810.3390/pharmaceutics15030948Potential Role of Vaginal Microbiota in Ovarian Cancer Carcinogenesis, Progression and TreatmentXiumiao Zhao0Zhaoxia Liu1Tingtao Chen2Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, ChinaDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, ChinaDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, ChinaOvarian cancer represents one of the most challenging gynecologic cancers which still has numerous unknowns on the underlying pathogenesis. In addition to the verified contributors such as genomic predisposition and medical history in the carcinogenesis, emerging evidence points out the potential role of vaginal microbiota in ovarian cancer. Recent studies have underlined the presence of vaginal microbial dysbiosis in cancer cases. Increasing research also indicates the potential correlations between vaginal microbes and cancer carcinogenesis, progression and treatment. Currently, compared with other gynecologic cancers, reports on the roles of vaginal microbiota in ovarian cancer remain scarce and fragmentary. Therefore, in this review, we summarize the roles of vaginal microbiota in various gynecologic diseases, particularly focusing on the potential mechanisms and possible applications of vaginal microbiota in ovarian cancer, giving insight into the involvement of vaginal microbiota in gynecologic cancer treatment.https://www.mdpi.com/1999-4923/15/3/948vaginal microbiotaovarian cancerprobioticsvaginal microbiota transplantation |
| spellingShingle | Xiumiao Zhao Zhaoxia Liu Tingtao Chen Potential Role of Vaginal Microbiota in Ovarian Cancer Carcinogenesis, Progression and Treatment Pharmaceutics vaginal microbiota ovarian cancer probiotics vaginal microbiota transplantation |
| title | Potential Role of Vaginal Microbiota in Ovarian Cancer Carcinogenesis, Progression and Treatment |
| title_full | Potential Role of Vaginal Microbiota in Ovarian Cancer Carcinogenesis, Progression and Treatment |
| title_fullStr | Potential Role of Vaginal Microbiota in Ovarian Cancer Carcinogenesis, Progression and Treatment |
| title_full_unstemmed | Potential Role of Vaginal Microbiota in Ovarian Cancer Carcinogenesis, Progression and Treatment |
| title_short | Potential Role of Vaginal Microbiota in Ovarian Cancer Carcinogenesis, Progression and Treatment |
| title_sort | potential role of vaginal microbiota in ovarian cancer carcinogenesis progression and treatment |
| topic | vaginal microbiota ovarian cancer probiotics vaginal microbiota transplantation |
| url | https://www.mdpi.com/1999-4923/15/3/948 |
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