Diminished Bone Marrow Oedema and Healing of Insufficiency Fractures in a HIV Patient after Switching Antiviral Therapies
This is a case report about the recurrent onset of bone marrow oedemas and insufficiency fractures in a 64-year-old male Human Immunodeficiency Virus (HIV)-patient, who was going through an antiviral treatment. The patient experienced stress-related pain and swelling in both ankle joints and feet,...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2021-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/14758/46215_CE[Ra1]_F[SK]_PF1(AKA_KM)_PFA(SHU)_PB(Su_AKA_KM)_PN(KM).pdf |
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| author | Sebastian Radmer Julian Ramin Andresen Reimer Andresen |
| author_facet | Sebastian Radmer Julian Ramin Andresen Reimer Andresen |
| author_sort | Sebastian Radmer |
| collection | DOAJ |
| description | This is a case report about the recurrent onset of bone marrow oedemas and insufficiency fractures in a 64-year-old male Human
Immunodeficiency Virus (HIV)-patient, who was going through an antiviral treatment. The patient experienced stress-related pain
and swelling in both ankle joints and feet, and was treated antivirally with Atripla® for several years. Therapeutically, conservative
treatment as well as a therapeutic trial with bisphosphonates were performed. As a result of developing renal insufficiency, antiviral
therapy was switched to a combination of Prezista® and Norvir®. Only after switching the antiviral therapy, there was a clear clinical
improvement of the symptoms. The clinical symptoms correlated well with Magnetic Resonance Imaging (MRI), the features of
which are detectable regressive bone marrow oedemas and the healing of insufficiency fractures. The impaired renal function
improved to a compensated retention. In the case of HIV patients with unclear joint complaints, the presence of bone marrow
oedema should be considered. |
| first_indexed | 2024-12-16T12:48:51Z |
| format | Article |
| id | doaj.art-e0c59b91fc5c407ca10858ccbdaea845 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-16T12:48:51Z |
| publishDate | 2021-03-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-e0c59b91fc5c407ca10858ccbdaea8452022-12-21T22:31:12ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2021-03-01153RD01RD0210.7860/JCDR/2021/46523.14738Diminished Bone Marrow Oedema and Healing of Insufficiency Fractures in a HIV Patient after Switching Antiviral TherapiesSebastian Radmer0Julian Ramin Andresen1Reimer Andresen2MD, Department of Orthopaedics, Centre for Orthopaedics, Berlin, Germany.BSc (Med), Department of Medical School, Sigmund Freud University, Vienna, Austria.MD, PhD, Department of Institute of Diagnostic and Interventional Radiology/Neuroradiology, Westkuestenklinikum Heide, Academic Teaching Hospital of the Universities of Kiel, Luebeck and Hambu, Heide, Schleswig-Holstein, Germany.This is a case report about the recurrent onset of bone marrow oedemas and insufficiency fractures in a 64-year-old male Human Immunodeficiency Virus (HIV)-patient, who was going through an antiviral treatment. The patient experienced stress-related pain and swelling in both ankle joints and feet, and was treated antivirally with Atripla® for several years. Therapeutically, conservative treatment as well as a therapeutic trial with bisphosphonates were performed. As a result of developing renal insufficiency, antiviral therapy was switched to a combination of Prezista® and Norvir®. Only after switching the antiviral therapy, there was a clear clinical improvement of the symptoms. The clinical symptoms correlated well with Magnetic Resonance Imaging (MRI), the features of which are detectable regressive bone marrow oedemas and the healing of insufficiency fractures. The impaired renal function improved to a compensated retention. In the case of HIV patients with unclear joint complaints, the presence of bone marrow oedema should be considered.https://www.jcdr.net/articles/PDF/14758/46215_CE[Ra1]_F[SK]_PF1(AKA_KM)_PFA(SHU)_PB(Su_AKA_KM)_PN(KM).pdfbone marrow oedema syndromefatigue fracturehuman immunodeficiency virusmedical therapyrenal insufficiencytenofovir |
| spellingShingle | Sebastian Radmer Julian Ramin Andresen Reimer Andresen Diminished Bone Marrow Oedema and Healing of Insufficiency Fractures in a HIV Patient after Switching Antiviral Therapies Journal of Clinical and Diagnostic Research bone marrow oedema syndrome fatigue fracture human immunodeficiency virus medical therapy renal insufficiency tenofovir |
| title | Diminished Bone Marrow Oedema and Healing of Insufficiency Fractures in a HIV Patient after Switching Antiviral Therapies |
| title_full | Diminished Bone Marrow Oedema and Healing of Insufficiency Fractures in a HIV Patient after Switching Antiviral Therapies |
| title_fullStr | Diminished Bone Marrow Oedema and Healing of Insufficiency Fractures in a HIV Patient after Switching Antiviral Therapies |
| title_full_unstemmed | Diminished Bone Marrow Oedema and Healing of Insufficiency Fractures in a HIV Patient after Switching Antiviral Therapies |
| title_short | Diminished Bone Marrow Oedema and Healing of Insufficiency Fractures in a HIV Patient after Switching Antiviral Therapies |
| title_sort | diminished bone marrow oedema and healing of insufficiency fractures in a hiv patient after switching antiviral therapies |
| topic | bone marrow oedema syndrome fatigue fracture human immunodeficiency virus medical therapy renal insufficiency tenofovir |
| url | https://www.jcdr.net/articles/PDF/14758/46215_CE[Ra1]_F[SK]_PF1(AKA_KM)_PFA(SHU)_PB(Su_AKA_KM)_PN(KM).pdf |
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