Influence of <i>Smallanthus sonchifolius</i> (Yacon) on the Activity of Antidepressant Drugs in Mice
Depression is one of the most common mental disorders in the world that negatively affects the daily functioning of patients. Numerous studies are currently being conducted to examine the antidepressant potential of innovative synthetic compounds and herbal substances. Yacon, <i>Smallantchus s...
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MDPI AG
2021-10-01
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| Online Access: | https://www.mdpi.com/2075-1729/11/11/1117 |
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| author | Sylwia Wośko Anna Serefko Aleksandra Szopa Sylwia Kardaś Jarosław Widelski Tomasz Mroczek Ewelina Rostkowska Jolanta Szymańska Ewa Poleszak |
| author_facet | Sylwia Wośko Anna Serefko Aleksandra Szopa Sylwia Kardaś Jarosław Widelski Tomasz Mroczek Ewelina Rostkowska Jolanta Szymańska Ewa Poleszak |
| author_sort | Sylwia Wośko |
| collection | DOAJ |
| description | Depression is one of the most common mental disorders in the world that negatively affects the daily functioning of patients. Numerous studies are currently being conducted to examine the antidepressant potential of innovative synthetic compounds and herbal substances. Yacon, <i>Smallantchus sonchifolius</i>, belongs to plants with numerous health-beneficial properties. Yacon-based products are regarded as a functional food. In our study, we attempted to check whether administration of Yacon tuber extract would have an antidepressant effect in the forced swim test (FST) in mice and whether its intake could influence the activity of conventional antidepressant drugs with different mechanisms of action, i.e., imipramine hydrochloride, fluoxetine hydrochloride, and reboxetine mesylate. The spontaneous locomotor activity of the tested mice was also investigated to eliminate any false-positive results. We demonstrated that an intragastric administration of the Yacon tuber extract at a dose of 100 mg/kg induced the antidepressant-like behavior in the FST in mice and that a combined administration of the sub-effective doses of the Yacon extract (50 mg/kg) with imipramine hydrochloride (7.5 mg/kg), fluoxetine hydrochloride (20 mg/kg), or reboxetine mesylate (5 mg/kg) significantly reduced the immobility time of animals in this behavioral test. The obtained results were not affected by the increased locomotor activity of the tested subjects. In conclusion, our findings suggest that Yacon tuber extract is promising as an alternative mood-improving product since it possesses an antidepressant potential and it can acts synergistically with conventional antidepressant drugs. |
| first_indexed | 2024-03-10T05:21:10Z |
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| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T05:21:10Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-e0c6a62f4ab14a9fb2ffdbf6779981b92023-11-23T00:03:02ZengMDPI AGLife2075-17292021-10-011111111710.3390/life11111117Influence of <i>Smallanthus sonchifolius</i> (Yacon) on the Activity of Antidepressant Drugs in MiceSylwia Wośko0Anna Serefko1Aleksandra Szopa2Sylwia Kardaś3Jarosław Widelski4Tomasz Mroczek5Ewelina Rostkowska6Jolanta Szymańska7Ewa Poleszak8Laboratory of Preclinical Testing, Chair and Department of Applied and Social Pharmacy, Medical University of Lublin, Chodźki 1, 20-093 Lublin, PolandLaboratory of Preclinical Testing, Chair and Department of Applied and Social Pharmacy, Medical University of Lublin, Chodźki 1, 20-093 Lublin, PolandLaboratory of Preclinical Testing, Chair and Department of Applied and Social Pharmacy, Medical University of Lublin, Chodźki 1, 20-093 Lublin, PolandStudent’s Scientific Circle at Laboratory of Preclinical Testing, Medical University of Lublin, Chodźki 1, 20-093 Lublin, PolandDepartment of Pharmacognosy, Medical University of Lublin, Chodźki 1, 20-093 Lublin, PolandIndependent Laboratory of Chemistry of Natural Products, Medical University of Lublin, Chodźki 1, 20-093 Lublin, PolandBeauty Salon “Clarie Beauty”, Pułaskiego 26, 20-461 Lublin, PolandDepartment of Integrated Paediatric Dentistry, Medical University of Lublin, Chodźki 6, 20-093 Lublin, PolandLaboratory of Preclinical Testing, Chair and Department of Applied and Social Pharmacy, Medical University of Lublin, Chodźki 1, 20-093 Lublin, PolandDepression is one of the most common mental disorders in the world that negatively affects the daily functioning of patients. Numerous studies are currently being conducted to examine the antidepressant potential of innovative synthetic compounds and herbal substances. Yacon, <i>Smallantchus sonchifolius</i>, belongs to plants with numerous health-beneficial properties. Yacon-based products are regarded as a functional food. In our study, we attempted to check whether administration of Yacon tuber extract would have an antidepressant effect in the forced swim test (FST) in mice and whether its intake could influence the activity of conventional antidepressant drugs with different mechanisms of action, i.e., imipramine hydrochloride, fluoxetine hydrochloride, and reboxetine mesylate. The spontaneous locomotor activity of the tested mice was also investigated to eliminate any false-positive results. We demonstrated that an intragastric administration of the Yacon tuber extract at a dose of 100 mg/kg induced the antidepressant-like behavior in the FST in mice and that a combined administration of the sub-effective doses of the Yacon extract (50 mg/kg) with imipramine hydrochloride (7.5 mg/kg), fluoxetine hydrochloride (20 mg/kg), or reboxetine mesylate (5 mg/kg) significantly reduced the immobility time of animals in this behavioral test. The obtained results were not affected by the increased locomotor activity of the tested subjects. In conclusion, our findings suggest that Yacon tuber extract is promising as an alternative mood-improving product since it possesses an antidepressant potential and it can acts synergistically with conventional antidepressant drugs.https://www.mdpi.com/2075-1729/11/11/1117Yacon (<i>Smallantchus sonchifolius</i>)imipraminefluoxetinereboxetineforced swim testmice |
| spellingShingle | Sylwia Wośko Anna Serefko Aleksandra Szopa Sylwia Kardaś Jarosław Widelski Tomasz Mroczek Ewelina Rostkowska Jolanta Szymańska Ewa Poleszak Influence of <i>Smallanthus sonchifolius</i> (Yacon) on the Activity of Antidepressant Drugs in Mice Life Yacon (<i>Smallantchus sonchifolius</i>) imipramine fluoxetine reboxetine forced swim test mice |
| title | Influence of <i>Smallanthus sonchifolius</i> (Yacon) on the Activity of Antidepressant Drugs in Mice |
| title_full | Influence of <i>Smallanthus sonchifolius</i> (Yacon) on the Activity of Antidepressant Drugs in Mice |
| title_fullStr | Influence of <i>Smallanthus sonchifolius</i> (Yacon) on the Activity of Antidepressant Drugs in Mice |
| title_full_unstemmed | Influence of <i>Smallanthus sonchifolius</i> (Yacon) on the Activity of Antidepressant Drugs in Mice |
| title_short | Influence of <i>Smallanthus sonchifolius</i> (Yacon) on the Activity of Antidepressant Drugs in Mice |
| title_sort | influence of i smallanthus sonchifolius i yacon on the activity of antidepressant drugs in mice |
| topic | Yacon (<i>Smallantchus sonchifolius</i>) imipramine fluoxetine reboxetine forced swim test mice |
| url | https://www.mdpi.com/2075-1729/11/11/1117 |
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