Interactive Effect of the Linum Usitatissimum Extracts and Exercise Rehabilitation on Aorta Endothelial and Heart Tissues Apoptosis Biomarkers
Introduction: As one of the most life-threatening illnesses, cardiovascular diseases are often discerned with a high apoptosis rate because of exposure to the high level of oxidative stresses. The present study has investigated the interaction of the Linum Usitatissimum (Lu) and aerobic exercise (Ae...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2021-09-01
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| Series: | Journal of Fasting and Health |
| Subjects: | |
| Online Access: | https://jnfh.mums.ac.ir/article_18490_3c5d3f526cc7f277e94cc32fbd081fb7.pdf |
| _version_ | 1797999776572112896 |
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| author | Seyed Mostafa Rezaei Bahram Abedi Hoseyn Fatolahi |
| author_facet | Seyed Mostafa Rezaei Bahram Abedi Hoseyn Fatolahi |
| author_sort | Seyed Mostafa Rezaei |
| collection | DOAJ |
| description | Introduction: As one of the most life-threatening illnesses, cardiovascular diseases are often discerned with a high apoptosis rate because of exposure to the high level of oxidative stresses. The present study has investigated the interaction of the Linum Usitatissimum (Lu) and aerobic exercise (Ae) on apoptosis of aortic endothelial and heart tissue in rats intoxicated by H2O2. Methods: 56 male Albino Wistar rats were divided into 7 groups, included HC (Healthy Control), TC (Toxic-Control), Toxic-Lu1 (Received Lu, 5 mg/kg), Toxic-Lu2 (Received Lu, 10 mg/kg), Toxic-Ae (Received Aerobic Exercise), Toxic-Ae+Lu1, and Toxic-Ae+Lu2. Finally, the rats were sacrificed ethically, and the apoptotic biomarkers were measured in isolated aortic endothelial and heart tissues. Results: The interactive comparisons showed that the Ae and Lu and aerobic exercise had a significant interactive change on pro-apoptosis biomarkers. The BAX in aortic endothelial (P=0.0011) and heart (P=0.0007), caspase-3 in aortic endothelial (P=0.0006) and heart (P=0.0016), and Bcl-2 in aortic endothelial (P=0.0018) and heart (P=0.0016) have significant interactive changes. No significant independent effect was observed. Post hoc test showed that group Toxic-Ae+Lu2 have the most significant improvement compared to the TC group (P≤0.05). Conclusions: The simultaneous effect of Ae and Lu supplementation most effectively improved the apoptosis biomarkers and displayed potent cardioprotective effects compared to the singular administration of each intervention. Probably, the short rehabilitation period has caused non- significant independent changes. However, the interaction of Ae and Lu has shortened the treatment period. |
| first_indexed | 2024-04-11T11:10:08Z |
| format | Article |
| id | doaj.art-e0c76c66a3e944ffbadce3a19d3e0ec2 |
| institution | Directory Open Access Journal |
| issn | 2345-2587 |
| language | English |
| last_indexed | 2024-04-11T11:10:08Z |
| publishDate | 2021-09-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Journal of Fasting and Health |
| spelling | doaj.art-e0c76c66a3e944ffbadce3a19d3e0ec22022-12-22T04:27:38ZengMashhad University of Medical SciencesJournal of Fasting and Health2345-25872021-09-019325426210.22038/jnfh.2021.57173.133118490Interactive Effect of the Linum Usitatissimum Extracts and Exercise Rehabilitation on Aorta Endothelial and Heart Tissues Apoptosis BiomarkersSeyed Mostafa Rezaei0Bahram Abedi1Hoseyn Fatolahi2Ph.D. Student, Department of Physical Education and Sport Sciences, Mahallat Branch, Islamic Azad University. Mahallat, Iran.Professor, Department of Physical Education and Sport Sciences, Mahallat Branch, Islamic Azad University. Mahallat, Iran.Assistant Professor, Department of Physical Education, Pardis Branch, Islamic Azad University, Pardis, Iran.Introduction: As one of the most life-threatening illnesses, cardiovascular diseases are often discerned with a high apoptosis rate because of exposure to the high level of oxidative stresses. The present study has investigated the interaction of the Linum Usitatissimum (Lu) and aerobic exercise (Ae) on apoptosis of aortic endothelial and heart tissue in rats intoxicated by H2O2. Methods: 56 male Albino Wistar rats were divided into 7 groups, included HC (Healthy Control), TC (Toxic-Control), Toxic-Lu1 (Received Lu, 5 mg/kg), Toxic-Lu2 (Received Lu, 10 mg/kg), Toxic-Ae (Received Aerobic Exercise), Toxic-Ae+Lu1, and Toxic-Ae+Lu2. Finally, the rats were sacrificed ethically, and the apoptotic biomarkers were measured in isolated aortic endothelial and heart tissues. Results: The interactive comparisons showed that the Ae and Lu and aerobic exercise had a significant interactive change on pro-apoptosis biomarkers. The BAX in aortic endothelial (P=0.0011) and heart (P=0.0007), caspase-3 in aortic endothelial (P=0.0006) and heart (P=0.0016), and Bcl-2 in aortic endothelial (P=0.0018) and heart (P=0.0016) have significant interactive changes. No significant independent effect was observed. Post hoc test showed that group Toxic-Ae+Lu2 have the most significant improvement compared to the TC group (P≤0.05). Conclusions: The simultaneous effect of Ae and Lu supplementation most effectively improved the apoptosis biomarkers and displayed potent cardioprotective effects compared to the singular administration of each intervention. Probably, the short rehabilitation period has caused non- significant independent changes. However, the interaction of Ae and Lu has shortened the treatment period.https://jnfh.mums.ac.ir/article_18490_3c5d3f526cc7f277e94cc32fbd081fb7.pdfh2o2 toxicityapoptosisoxidative stresseslinum usitatissimumaerobic exercise |
| spellingShingle | Seyed Mostafa Rezaei Bahram Abedi Hoseyn Fatolahi Interactive Effect of the Linum Usitatissimum Extracts and Exercise Rehabilitation on Aorta Endothelial and Heart Tissues Apoptosis Biomarkers Journal of Fasting and Health h2o2 toxicity apoptosis oxidative stresses linum usitatissimum aerobic exercise |
| title | Interactive Effect of the Linum Usitatissimum Extracts and Exercise Rehabilitation on Aorta Endothelial and Heart Tissues Apoptosis Biomarkers |
| title_full | Interactive Effect of the Linum Usitatissimum Extracts and Exercise Rehabilitation on Aorta Endothelial and Heart Tissues Apoptosis Biomarkers |
| title_fullStr | Interactive Effect of the Linum Usitatissimum Extracts and Exercise Rehabilitation on Aorta Endothelial and Heart Tissues Apoptosis Biomarkers |
| title_full_unstemmed | Interactive Effect of the Linum Usitatissimum Extracts and Exercise Rehabilitation on Aorta Endothelial and Heart Tissues Apoptosis Biomarkers |
| title_short | Interactive Effect of the Linum Usitatissimum Extracts and Exercise Rehabilitation on Aorta Endothelial and Heart Tissues Apoptosis Biomarkers |
| title_sort | interactive effect of the linum usitatissimum extracts and exercise rehabilitation on aorta endothelial and heart tissues apoptosis biomarkers |
| topic | h2o2 toxicity apoptosis oxidative stresses linum usitatissimum aerobic exercise |
| url | https://jnfh.mums.ac.ir/article_18490_3c5d3f526cc7f277e94cc32fbd081fb7.pdf |
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