Analysis of the Peripapillary and Macular Regions Using OCT Angiography in Patients with Schizophrenia and Bipolar Disorder
Purpose: To measure RNFL and vasculature around the optic disc and in the macula in patients with schizophrenia (SZ) and bipolar disorder (BD) using optical coherence tomography angiography (OCTA). Methods: 24 eyes of patients with SZ and 16 eyes of patients with BD as well as 30 eyes of healthy sub...
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MDPI AG
2021-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/18/4131 |
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| author | Edyta Koman-Wierdak Joanna Róg Agnieszka Brzozowska Mario Damiano Toro Vincenza Bonfiglio Katarzyna Załuska-Ogryzek Hanna Karakuła-Juchnowicz Robert Rejdak Katarzyna Nowomiejska |
| author_facet | Edyta Koman-Wierdak Joanna Róg Agnieszka Brzozowska Mario Damiano Toro Vincenza Bonfiglio Katarzyna Załuska-Ogryzek Hanna Karakuła-Juchnowicz Robert Rejdak Katarzyna Nowomiejska |
| author_sort | Edyta Koman-Wierdak |
| collection | DOAJ |
| description | Purpose: To measure RNFL and vasculature around the optic disc and in the macula in patients with schizophrenia (SZ) and bipolar disorder (BD) using optical coherence tomography angiography (OCTA). Methods: 24 eyes of patients with SZ and 16 eyes of patients with BD as well as 30 eyes of healthy subjects were examined with OCTA. The radiant peripapillary capillary (RPC) density and RNFL thickness were measured in the peripapillary area. Moreover, macular thickness and vessel density were measured in both superficial and deep layers. Results: Significantly decreased values of vessel density in the macular deep vascular complex were found in the eyes of patients with SZ, compared to BD and the control group. The macular thickness in the whole vascular complex and in the fovea was significantly lower in SZ and BD group than in the control group. The radiant peripapillary vascular density and RNFL thickness were similar across groups. Conclusions: The retinal microvascular dysfunction occurs in the macula in patients with SZ and BD, but not around optic disc. OCTA can become an essential additional diagnostic tool in detection of psychiatric disorders. |
| first_indexed | 2024-03-10T07:34:18Z |
| format | Article |
| id | doaj.art-e0ca188e1e4c46b6b1bc3fcd2eb74fad |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T07:34:18Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-e0ca188e1e4c46b6b1bc3fcd2eb74fad2023-11-22T13:39:57ZengMDPI AGJournal of Clinical Medicine2077-03832021-09-011018413110.3390/jcm10184131Analysis of the Peripapillary and Macular Regions Using OCT Angiography in Patients with Schizophrenia and Bipolar DisorderEdyta Koman-Wierdak0Joanna Róg1Agnieszka Brzozowska2Mario Damiano Toro3Vincenza Bonfiglio4Katarzyna Załuska-Ogryzek5Hanna Karakuła-Juchnowicz6Robert Rejdak7Katarzyna Nowomiejska8Department of General Ophthalmology, Medical University of Lublin, 20-079 Lublin, PolandDepartment of Psychiatry, Psychotherapy and Early Intervention, Medical University of Lublin, 20-079 Lublin, PolandDepartment of Mathematics and Medical Biostatistics, Medical University of Lublin, 20-079 Lublin, PolandDepartment of General Ophthalmology, Medical University of Lublin, 20-079 Lublin, PolandDepartment of Experimental Biomedicine and Clinical Neuroscience, Ophthalmology Section, University of Palermo, 90127 Palermo, ItalyDepartment of Pathophysiology, Medical University of Lublin, 20-079 Lublin, PolandDepartment of Psychiatry, Psychotherapy and Early Intervention, Medical University of Lublin, 20-079 Lublin, PolandDepartment of General Ophthalmology, Medical University of Lublin, 20-079 Lublin, PolandDepartment of General Ophthalmology, Medical University of Lublin, 20-079 Lublin, PolandPurpose: To measure RNFL and vasculature around the optic disc and in the macula in patients with schizophrenia (SZ) and bipolar disorder (BD) using optical coherence tomography angiography (OCTA). Methods: 24 eyes of patients with SZ and 16 eyes of patients with BD as well as 30 eyes of healthy subjects were examined with OCTA. The radiant peripapillary capillary (RPC) density and RNFL thickness were measured in the peripapillary area. Moreover, macular thickness and vessel density were measured in both superficial and deep layers. Results: Significantly decreased values of vessel density in the macular deep vascular complex were found in the eyes of patients with SZ, compared to BD and the control group. The macular thickness in the whole vascular complex and in the fovea was significantly lower in SZ and BD group than in the control group. The radiant peripapillary vascular density and RNFL thickness were similar across groups. Conclusions: The retinal microvascular dysfunction occurs in the macula in patients with SZ and BD, but not around optic disc. OCTA can become an essential additional diagnostic tool in detection of psychiatric disorders.https://www.mdpi.com/2077-0383/10/18/4131OCTAschizophreniabipolar disordermicrovascular dysfunction |
| spellingShingle | Edyta Koman-Wierdak Joanna Róg Agnieszka Brzozowska Mario Damiano Toro Vincenza Bonfiglio Katarzyna Załuska-Ogryzek Hanna Karakuła-Juchnowicz Robert Rejdak Katarzyna Nowomiejska Analysis of the Peripapillary and Macular Regions Using OCT Angiography in Patients with Schizophrenia and Bipolar Disorder Journal of Clinical Medicine OCTA schizophrenia bipolar disorder microvascular dysfunction |
| title | Analysis of the Peripapillary and Macular Regions Using OCT Angiography in Patients with Schizophrenia and Bipolar Disorder |
| title_full | Analysis of the Peripapillary and Macular Regions Using OCT Angiography in Patients with Schizophrenia and Bipolar Disorder |
| title_fullStr | Analysis of the Peripapillary and Macular Regions Using OCT Angiography in Patients with Schizophrenia and Bipolar Disorder |
| title_full_unstemmed | Analysis of the Peripapillary and Macular Regions Using OCT Angiography in Patients with Schizophrenia and Bipolar Disorder |
| title_short | Analysis of the Peripapillary and Macular Regions Using OCT Angiography in Patients with Schizophrenia and Bipolar Disorder |
| title_sort | analysis of the peripapillary and macular regions using oct angiography in patients with schizophrenia and bipolar disorder |
| topic | OCTA schizophrenia bipolar disorder microvascular dysfunction |
| url | https://www.mdpi.com/2077-0383/10/18/4131 |
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