The Effect of Propolis in Healing Injured Nasal Mucosa: An Experimental Study
Abstract Introduction Mechanical trauma to the nasal mucosa increases the risk of synechia formation, especially after chronic rhinosinusitis and nasal surgeries. Objective This study was carried to assess the effect of propolis administration in healing injured nasal mucos...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2016-02-01
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| Series: | International Archives of Otorhinolaryngology |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1579664 |
| _version_ | 1811339729611784192 |
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| author | Mohammad Waheed El-Anwar Said Abdelmonem Ahmed A. Abdelsameea Mohamed AlShawadfy Kamal El-Kashishy |
| author_facet | Mohammad Waheed El-Anwar Said Abdelmonem Ahmed A. Abdelsameea Mohamed AlShawadfy Kamal El-Kashishy |
| author_sort | Mohammad Waheed El-Anwar |
| collection | DOAJ |
| description | Abstract
Introduction Mechanical trauma to the nasal mucosa increases the risk of synechia formation, especially after chronic rhinosinusitis and nasal surgeries.
Objective This study was carried to assess the effect of propolis administration in healing injured nasal mucosa in rats.
Methods We randomly divided eighteen rats into three equal experimental groups: (1) non-treated group; (2) gum tragacanth (suspending agent for propolis) treated group; and (3) propolis treated group. The non-treated group received no treatment for 15 days. The second group received gum tragacanth administration (5 ml/kg, orally) once daily for 15 days. The third group received propolis suspension orally at a dose of 100 mg/kg once daily for 15 days. At the beginning of this study, we induced unilateral mechanical nasal trauma on the right nasal mucosa of all rats in the three groups using a brushing technique. A pathologist stained tissue samples using hematoxylin and examined eosin by using a light microscope.
Results The severity of inflammation was milder with the absence of ulcerations in the propolis treated group compared with the non-treated and gum tragacanth groups. Goblet cell and ciliated cell loss was substantially lower in patients treated with propolis compared with groups without treatment and those treated with gum tragacanth.
Conclusion Propolis decreased inflammation and enhanced healing of wounds of the nasal mucosa in rats. |
| first_indexed | 2024-04-13T18:30:54Z |
| format | Article |
| id | doaj.art-e0cb409ae09347e6a9bce806eec4e010 |
| institution | Directory Open Access Journal |
| issn | 1809-9777 1809-4864 |
| language | English |
| last_indexed | 2024-04-13T18:30:54Z |
| publishDate | 2016-02-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | International Archives of Otorhinolaryngology |
| spelling | doaj.art-e0cb409ae09347e6a9bce806eec4e0102022-12-22T02:35:05ZengThieme Revinter Publicações Ltda.International Archives of Otorhinolaryngology1809-97771809-48642016-02-01200322222510.1055/s-0036-1579664The Effect of Propolis in Healing Injured Nasal Mucosa: An Experimental StudyMohammad Waheed El-Anwar0Said Abdelmonem1Ahmed A. Abdelsameea2Mohamed AlShawadfy3Kamal El-Kashishy4Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Zagazig University, Zagazig, EgyptDepartment of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Zagazig University, Zagazig, EgyptDepartment of Pharmacology, Faculty of Medicine, Zagazig University, Zagazig, EgyptDepartment of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Zagazig University, Zagazig, EgyptDepartment of Pathology, School of Medicine, Zagazig University, Zagazig, EgyptAbstract Introduction Mechanical trauma to the nasal mucosa increases the risk of synechia formation, especially after chronic rhinosinusitis and nasal surgeries. Objective This study was carried to assess the effect of propolis administration in healing injured nasal mucosa in rats. Methods We randomly divided eighteen rats into three equal experimental groups: (1) non-treated group; (2) gum tragacanth (suspending agent for propolis) treated group; and (3) propolis treated group. The non-treated group received no treatment for 15 days. The second group received gum tragacanth administration (5 ml/kg, orally) once daily for 15 days. The third group received propolis suspension orally at a dose of 100 mg/kg once daily for 15 days. At the beginning of this study, we induced unilateral mechanical nasal trauma on the right nasal mucosa of all rats in the three groups using a brushing technique. A pathologist stained tissue samples using hematoxylin and examined eosin by using a light microscope. Results The severity of inflammation was milder with the absence of ulcerations in the propolis treated group compared with the non-treated and gum tragacanth groups. Goblet cell and ciliated cell loss was substantially lower in patients treated with propolis compared with groups without treatment and those treated with gum tragacanth. Conclusion Propolis decreased inflammation and enhanced healing of wounds of the nasal mucosa in rats.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1579664nasal mucosapropolisrat |
| spellingShingle | Mohammad Waheed El-Anwar Said Abdelmonem Ahmed A. Abdelsameea Mohamed AlShawadfy Kamal El-Kashishy The Effect of Propolis in Healing Injured Nasal Mucosa: An Experimental Study International Archives of Otorhinolaryngology nasal mucosa propolis rat |
| title | The Effect of Propolis in Healing Injured Nasal Mucosa: An Experimental Study |
| title_full | The Effect of Propolis in Healing Injured Nasal Mucosa: An Experimental Study |
| title_fullStr | The Effect of Propolis in Healing Injured Nasal Mucosa: An Experimental Study |
| title_full_unstemmed | The Effect of Propolis in Healing Injured Nasal Mucosa: An Experimental Study |
| title_short | The Effect of Propolis in Healing Injured Nasal Mucosa: An Experimental Study |
| title_sort | effect of propolis in healing injured nasal mucosa an experimental study |
| topic | nasal mucosa propolis rat |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1579664 |
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