The effect of low-dose intravenous ketamine on continuous intercostal analgesia following thoracotomy
Ketamine, a noncompetitive N-methyl-d-aspartate antagonist, provides analgesia and prevents chronic pain following thoracotomy. The study was aimed to assess the effect of intravenous low-dose ketamine on continuous intercostal nerve block analgesia following thoracotomy. The study was a prospective...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Annals of Cardiac Anaesthesia |
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| Online Access: | http://www.annals.in/article.asp?issn=0971-9784;year=2012;volume=15;issue=1;spage=32;epage=38;aulast=Yazigi |
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| author | Alexandre Yazigi Hicham Abou-Zeid Tamara Srouji Samia Madi-Jebara Fadia Haddad Khalil Jabbour |
| author_facet | Alexandre Yazigi Hicham Abou-Zeid Tamara Srouji Samia Madi-Jebara Fadia Haddad Khalil Jabbour |
| author_sort | Alexandre Yazigi |
| collection | DOAJ |
| description | Ketamine, a noncompetitive N-methyl-d-aspartate antagonist, provides analgesia and prevents chronic pain following thoracotomy. The study was aimed to assess the effect of intravenous low-dose ketamine on continuous intercostal nerve block analgesia following thoracotomy. The study was a prospective, randomized, double-blinded, and placebo-controlled clinical study, performed in a single university hospital. Sixty patients, undergoing elective lobectomy through an open posterolateral thoracotomy, were included. For postoperative pain, all patients received a continuous intercostal nerve block with bupivacaine plus intravenous paracetamol and ketoprofen. In addition, patients were randomized to have intravenous ketamine (0.1 mg/kg as a preincisional bolus followed by a continuous infusion of 0.05 mg/kg/h) in group 1 or intravenous placebo in group 2. Patients reporting a visual analog scale pain score at rest ≥40 mm received intravenous morphine sulfate as rescue analgesia. The following parameters were assessed every 6 hours for 3 postoperative days: Visual analog scale pain scores at rest and during coughing, requirement of rescue analgesia with morphine, Ramsay sedation scores and psychomimetic adverse effects. Both the groups were statistically comparable regarding visual analog scale pain scores at rest (P=0.75) and during coughing (P=0.70), number of morphine deliveries (P=0.17), cumulative dose of rescue morphine (P=0.2), sedation scores (P=0.4), and psychomimetic adverse effects (P=0.09). Intravenous low-dose ketamine, when combined with continuous intercostal nerve block, did not decrease acute pain scores and supplemental morphine consumption following thoracotomy. |
| first_indexed | 2024-12-12T14:07:40Z |
| format | Article |
| id | doaj.art-e0cbef8883d74382a284256699566c70 |
| institution | Directory Open Access Journal |
| issn | 0971-9784 |
| language | English |
| last_indexed | 2024-12-12T14:07:40Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Cardiac Anaesthesia |
| spelling | doaj.art-e0cbef8883d74382a284256699566c702022-12-22T00:22:11ZengWolters Kluwer Medknow PublicationsAnnals of Cardiac Anaesthesia0971-97842012-01-01151323810.4103/0971-9784.91479The effect of low-dose intravenous ketamine on continuous intercostal analgesia following thoracotomyAlexandre YazigiHicham Abou-ZeidTamara SroujiSamia Madi-JebaraFadia HaddadKhalil JabbourKetamine, a noncompetitive N-methyl-d-aspartate antagonist, provides analgesia and prevents chronic pain following thoracotomy. The study was aimed to assess the effect of intravenous low-dose ketamine on continuous intercostal nerve block analgesia following thoracotomy. The study was a prospective, randomized, double-blinded, and placebo-controlled clinical study, performed in a single university hospital. Sixty patients, undergoing elective lobectomy through an open posterolateral thoracotomy, were included. For postoperative pain, all patients received a continuous intercostal nerve block with bupivacaine plus intravenous paracetamol and ketoprofen. In addition, patients were randomized to have intravenous ketamine (0.1 mg/kg as a preincisional bolus followed by a continuous infusion of 0.05 mg/kg/h) in group 1 or intravenous placebo in group 2. Patients reporting a visual analog scale pain score at rest ≥40 mm received intravenous morphine sulfate as rescue analgesia. The following parameters were assessed every 6 hours for 3 postoperative days: Visual analog scale pain scores at rest and during coughing, requirement of rescue analgesia with morphine, Ramsay sedation scores and psychomimetic adverse effects. Both the groups were statistically comparable regarding visual analog scale pain scores at rest (P=0.75) and during coughing (P=0.70), number of morphine deliveries (P=0.17), cumulative dose of rescue morphine (P=0.2), sedation scores (P=0.4), and psychomimetic adverse effects (P=0.09). Intravenous low-dose ketamine, when combined with continuous intercostal nerve block, did not decrease acute pain scores and supplemental morphine consumption following thoracotomy.http://www.annals.in/article.asp?issn=0971-9784;year=2012;volume=15;issue=1;spage=32;epage=38;aulast=YazigiIntercostal nerve blockketaminepostoperative painthoracotomy |
| spellingShingle | Alexandre Yazigi Hicham Abou-Zeid Tamara Srouji Samia Madi-Jebara Fadia Haddad Khalil Jabbour The effect of low-dose intravenous ketamine on continuous intercostal analgesia following thoracotomy Annals of Cardiac Anaesthesia Intercostal nerve block ketamine postoperative pain thoracotomy |
| title | The effect of low-dose intravenous ketamine on continuous intercostal analgesia following thoracotomy |
| title_full | The effect of low-dose intravenous ketamine on continuous intercostal analgesia following thoracotomy |
| title_fullStr | The effect of low-dose intravenous ketamine on continuous intercostal analgesia following thoracotomy |
| title_full_unstemmed | The effect of low-dose intravenous ketamine on continuous intercostal analgesia following thoracotomy |
| title_short | The effect of low-dose intravenous ketamine on continuous intercostal analgesia following thoracotomy |
| title_sort | effect of low dose intravenous ketamine on continuous intercostal analgesia following thoracotomy |
| topic | Intercostal nerve block ketamine postoperative pain thoracotomy |
| url | http://www.annals.in/article.asp?issn=0971-9784;year=2012;volume=15;issue=1;spage=32;epage=38;aulast=Yazigi |
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