Intestinal fibrosis in aganglionic segment of Hirschsprung's disease revealed by single‐cell RNA sequencing

Intestinal fibrosis in aganglionic segment of Hirschsprung's disease revealed by single‐cell RNA sequencing

Abstract Background Hirschsprung's disease (HSCR) is a relatively common congenital disability. Accumulating extracellular matrix (ECM) prompts intestinal fibrosis remodelling in the aganglionic segments of HSCR. The contributions of various cellular subsets in the fibrogenesis of HSCR segments...

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Bibliographic Details
Main Authors: Shiwei He, Junfeng Wang, Yanlei Huang, Fanyang Kong, Ran Yang, Yong Zhan, Zifeng Li, Chunjing Ye, Lingdu Meng, Yankang Ren, Ying Zhou, Gong Chen, Zhen Shen, Song Sun, Shan Zheng, Rui Dong
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Clinical and Translational Medicine
Subjects:
extracellular matrix
Hirschsprung
intestinal fibrosis
single‐cell transcriptomics
Online Access:https://doi.org/10.1002/ctm2.1193

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