Adult Food Protein-Induced Enterocolitis Syndrome
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE, cell-mediated food allergy, commonly diagnosed in infants and young children. In recent years, new-onset adult FPIES has been recognized. The underlying pathogenic mechanism of FPIES has yet to be elucidated, thus disease-specific dia...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Allergy |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/falgy.2022.889879/full |
| _version_ | 1811254021613158400 |
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| author | Sara Anvari Sara Anvari Melanie A. Ruffner Melanie A. Ruffner |
| author_facet | Sara Anvari Sara Anvari Melanie A. Ruffner Melanie A. Ruffner |
| author_sort | Sara Anvari |
| collection | DOAJ |
| description | Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE, cell-mediated food allergy, commonly diagnosed in infants and young children. In recent years, new-onset adult FPIES has been recognized. The underlying pathogenic mechanism of FPIES has yet to be elucidated, thus disease-specific diagnostic biomarkers have yet to be determined and an oral food challenge (OFC) remains the gold-standard for the diagnosis. Pediatric patients with FPIES classically present with symptoms of delayed, repetitive vomiting approximately 1 to 4 hours following ingestion of a food allergen. However, adults with FPIES have been reported to have a different symptom profile and different food triggers compared to the pediatric FPIES population. The current FPIES diagnostic criteria may not be appropriate for the diagnosis of adult FPIES patients, thus an oral food challenge remains a diagnostic tool. This review provides an overview of the current literature on the clinical presentation, epidemiology, diagnosis, triggers and management of adult FPIES. |
| first_indexed | 2024-04-12T17:00:54Z |
| format | Article |
| id | doaj.art-e0ceb518626b4f6383f2eba61ebf2ae1 |
| institution | Directory Open Access Journal |
| issn | 2673-6101 |
| language | English |
| last_indexed | 2024-04-12T17:00:54Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Allergy |
| spelling | doaj.art-e0ceb518626b4f6383f2eba61ebf2ae12022-12-22T03:24:05ZengFrontiers Media S.A.Frontiers in Allergy2673-61012022-05-01310.3389/falgy.2022.889879889879Adult Food Protein-Induced Enterocolitis SyndromeSara Anvari0Sara Anvari1Melanie A. Ruffner2Melanie A. Ruffner3Division of Immunology, Allergy, and Retrovirology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, United StatesWilliam T. Shearer Center for Human Immunobiology, Texas Children's Hospital, Houston, TX, United StatesDivision of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, United StatesDepartment of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United StatesFood protein-induced enterocolitis syndrome (FPIES) is a non-IgE, cell-mediated food allergy, commonly diagnosed in infants and young children. In recent years, new-onset adult FPIES has been recognized. The underlying pathogenic mechanism of FPIES has yet to be elucidated, thus disease-specific diagnostic biomarkers have yet to be determined and an oral food challenge (OFC) remains the gold-standard for the diagnosis. Pediatric patients with FPIES classically present with symptoms of delayed, repetitive vomiting approximately 1 to 4 hours following ingestion of a food allergen. However, adults with FPIES have been reported to have a different symptom profile and different food triggers compared to the pediatric FPIES population. The current FPIES diagnostic criteria may not be appropriate for the diagnosis of adult FPIES patients, thus an oral food challenge remains a diagnostic tool. This review provides an overview of the current literature on the clinical presentation, epidemiology, diagnosis, triggers and management of adult FPIES.https://www.frontiersin.org/articles/10.3389/falgy.2022.889879/fullfood protein-induced enterocolitis syndromenon-IgE allergyadult food allergyfood allergygastrointestinal allergy |
| spellingShingle | Sara Anvari Sara Anvari Melanie A. Ruffner Melanie A. Ruffner Adult Food Protein-Induced Enterocolitis Syndrome Frontiers in Allergy food protein-induced enterocolitis syndrome non-IgE allergy adult food allergy food allergy gastrointestinal allergy |
| title | Adult Food Protein-Induced Enterocolitis Syndrome |
| title_full | Adult Food Protein-Induced Enterocolitis Syndrome |
| title_fullStr | Adult Food Protein-Induced Enterocolitis Syndrome |
| title_full_unstemmed | Adult Food Protein-Induced Enterocolitis Syndrome |
| title_short | Adult Food Protein-Induced Enterocolitis Syndrome |
| title_sort | adult food protein induced enterocolitis syndrome |
| topic | food protein-induced enterocolitis syndrome non-IgE allergy adult food allergy food allergy gastrointestinal allergy |
| url | https://www.frontiersin.org/articles/10.3389/falgy.2022.889879/full |
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