Repressed Exercise-Induced Hepcidin Levels after Danggui Buxue Tang Supplementation in Male Recreational Runners
This study was to investigate the protective and recovery effects of Danggui Buxue Tang (DBT) supplementation on exercise performance, hepcidin, iron status, and other related biochemical parameters after being challenged by a single bout of intense aerobic exercise. A total of 36 recreationally act...
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MDPI AG
2018-09-01
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| Series: | Nutrients |
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| Online Access: | http://www.mdpi.com/2072-6643/10/9/1318 |
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| author | Chih-Wei Chang Chao-Yen Chen Ching-Chi Yen Yu-Tse Wu Mei-Chich Hsu |
| author_facet | Chih-Wei Chang Chao-Yen Chen Ching-Chi Yen Yu-Tse Wu Mei-Chich Hsu |
| author_sort | Chih-Wei Chang |
| collection | DOAJ |
| description | This study was to investigate the protective and recovery effects of Danggui Buxue Tang (DBT) supplementation on exercise performance, hepcidin, iron status, and other related biochemical parameters after being challenged by a single bout of intense aerobic exercise. A total of 36 recreationally active males were pair-matched and randomly assigned to receive DBT or a placebo for 11 days, while using clusters based on their aerobic capacities. On the eighth day of the supplementation, the participants performed a 13-km run with maximal effort. Blood and urine samples were collected and analysed before treatment (Pre-Tre) and immediately after (Post-Ex), 24 h after (24-h Rec), and 72 h after (72-h Rec) the run. DBT supplementation dramatically shortened the finish times by 14.0% (12.3 min) when compared with that in the placebo group. Significant group × time effects were observed in serum hepcidin and iron levels. DBT supplementation repressed hepcidin levels at Post-Ex and 24-h Rec, thereby causing a significant increase in iron levels by 63.3% and 31.4% at Post-Ex and 72-h Rec, respectively. However, DBT supplementation had no significant anti-inflammatory or haemolysis-preventative effects. Short-term DBT supplementation shortened the running time and repressed exercise-induced hepcidin levels, thereby boosting iron levels and accelerating iron homeostasis during recovery. |
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| language | English |
| last_indexed | 2024-04-12T21:30:37Z |
| publishDate | 2018-09-01 |
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| spelling | doaj.art-e0d0232031534239b7bc32da0f4daaf92022-12-22T03:16:03ZengMDPI AGNutrients2072-66432018-09-01109131810.3390/nu10091318nu10091318Repressed Exercise-Induced Hepcidin Levels after Danggui Buxue Tang Supplementation in Male Recreational RunnersChih-Wei Chang0Chao-Yen Chen1Ching-Chi Yen2Yu-Tse Wu3Mei-Chich Hsu4School of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, TaiwanCenter for Physical Education, Kaohsiung Medical University, Kaohsiung 80708, TaiwanSchool of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, TaiwanSchool of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDepartment of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80756, TaiwanThis study was to investigate the protective and recovery effects of Danggui Buxue Tang (DBT) supplementation on exercise performance, hepcidin, iron status, and other related biochemical parameters after being challenged by a single bout of intense aerobic exercise. A total of 36 recreationally active males were pair-matched and randomly assigned to receive DBT or a placebo for 11 days, while using clusters based on their aerobic capacities. On the eighth day of the supplementation, the participants performed a 13-km run with maximal effort. Blood and urine samples were collected and analysed before treatment (Pre-Tre) and immediately after (Post-Ex), 24 h after (24-h Rec), and 72 h after (72-h Rec) the run. DBT supplementation dramatically shortened the finish times by 14.0% (12.3 min) when compared with that in the placebo group. Significant group × time effects were observed in serum hepcidin and iron levels. DBT supplementation repressed hepcidin levels at Post-Ex and 24-h Rec, thereby causing a significant increase in iron levels by 63.3% and 31.4% at Post-Ex and 72-h Rec, respectively. However, DBT supplementation had no significant anti-inflammatory or haemolysis-preventative effects. Short-term DBT supplementation shortened the running time and repressed exercise-induced hepcidin levels, thereby boosting iron levels and accelerating iron homeostasis during recovery.http://www.mdpi.com/2072-6643/10/9/1318iron deficiencyexercise performanceAngelica sinensisAstragalus membranaceustraditional Chinese medicinesports nutrition |
| spellingShingle | Chih-Wei Chang Chao-Yen Chen Ching-Chi Yen Yu-Tse Wu Mei-Chich Hsu Repressed Exercise-Induced Hepcidin Levels after Danggui Buxue Tang Supplementation in Male Recreational Runners Nutrients iron deficiency exercise performance Angelica sinensis Astragalus membranaceus traditional Chinese medicine sports nutrition |
| title | Repressed Exercise-Induced Hepcidin Levels after Danggui Buxue Tang Supplementation in Male Recreational Runners |
| title_full | Repressed Exercise-Induced Hepcidin Levels after Danggui Buxue Tang Supplementation in Male Recreational Runners |
| title_fullStr | Repressed Exercise-Induced Hepcidin Levels after Danggui Buxue Tang Supplementation in Male Recreational Runners |
| title_full_unstemmed | Repressed Exercise-Induced Hepcidin Levels after Danggui Buxue Tang Supplementation in Male Recreational Runners |
| title_short | Repressed Exercise-Induced Hepcidin Levels after Danggui Buxue Tang Supplementation in Male Recreational Runners |
| title_sort | repressed exercise induced hepcidin levels after danggui buxue tang supplementation in male recreational runners |
| topic | iron deficiency exercise performance Angelica sinensis Astragalus membranaceus traditional Chinese medicine sports nutrition |
| url | http://www.mdpi.com/2072-6643/10/9/1318 |
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