Clinical characteristics and outcomes of incident cases of COVID-19 in unvaccinated adult cystic fibrosis patients in southern Brazil: a prospective cohort study conducted during the first year of the COVID-19 pandemic
ABSTRACT Objective: There is still limited information on the clinical characteristics and outcomes of cystic fibrosis (CF) patients with COVID-19 in Brazil. The objective of this study was to describe the cumulative incidence of COVID-19 in CF patients, as well as their clinical characteristics an...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Pneumologia e Tisiologia
2022-11-01
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| Series: | Jornal Brasileiro de Pneumologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132022000600203&tlng=pt |
| _version_ | 1828182774014541824 |
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| author | Cristiane Christ Camargo Letícia Bauer Jacobsen Jaqueline Wilsmann Michelle Nunes Silveira Bruna Ziegler Elis de Pellegrin Rossi Carla Tatiana Oliveira Paulo de Tarso Roth Dalcin |
| author_facet | Cristiane Christ Camargo Letícia Bauer Jacobsen Jaqueline Wilsmann Michelle Nunes Silveira Bruna Ziegler Elis de Pellegrin Rossi Carla Tatiana Oliveira Paulo de Tarso Roth Dalcin |
| author_sort | Cristiane Christ Camargo |
| collection | DOAJ |
| description | ABSTRACT Objective: There is still limited information on the clinical characteristics and outcomes of cystic fibrosis (CF) patients with COVID-19 in Brazil. The objective of this study was to describe the cumulative incidence of COVID-19 in CF patients, as well as their clinical characteristics and outcomes. Methods: This was a prospective cohort study involving unvaccinated adult CF patients and conducted during the first year of the SARS-CoV-2 pandemic in the city of Porto Alegre, in southern Brazil. The clinical course of the disease was rated on the WHO Ordinal Scale for Clinical Improvement. The primary outcome was the number of incident cases of COVID-19. Results: Between April 30, 2020 and April 29, 2021, 98 CF patients were included in the study. Seventeen patients were diagnosed with COVID-19. For the CF patients, the annual cumulative incidence of COVID-19 was 17.3%, similar to that for the general population, adjusted for age (18.5%). The most common symptoms at diagnosis of COVID-19 were cough (in 59%), dyspnea (in 53%), fatigue (in 53%), and fever (in 47%). Only 6 (35%) of the patients required hospitalization, and 3 (17.6%) required oxygen support. Only 1 patient required mechanical ventilation, having subsequently died. Conclusions: During the first year of the SARS-CoV-2 pandemic in southern Brazil, the cumulative incidence rate of COVID-19 was similar between CF patients and the general population. More than 50% of the CF patients with SARS-CoV-2 infection had a mild clinical presentation, without the need for hospital admission, and almost the entire sample recovered completely from the infection, the exception being 1 patient who had advanced lung disease and who died. |
| first_indexed | 2024-04-12T06:23:03Z |
| format | Article |
| id | doaj.art-e0d06ee505ce46eb903abee0102948b6 |
| institution | Directory Open Access Journal |
| issn | 1806-3756 |
| language | English |
| last_indexed | 2024-04-12T06:23:03Z |
| publishDate | 2022-11-01 |
| publisher | Sociedade Brasileira de Pneumologia e Tisiologia |
| record_format | Article |
| series | Jornal Brasileiro de Pneumologia |
| spelling | doaj.art-e0d06ee505ce46eb903abee0102948b62022-12-22T03:44:16ZengSociedade Brasileira de Pneumologia e TisiologiaJornal Brasileiro de Pneumologia1806-37562022-11-0148610.36416/1806-3756/e20220265Clinical characteristics and outcomes of incident cases of COVID-19 in unvaccinated adult cystic fibrosis patients in southern Brazil: a prospective cohort study conducted during the first year of the COVID-19 pandemicCristiane Christ CamargoLetícia Bauer Jacobsenhttps://orcid.org/0000-0003-0624-456XJaqueline Wilsmannhttps://orcid.org/0000-0002-3406-098XMichelle Nunes Silveirahttps://orcid.org/0000-0002-0984-8169Bruna Zieglerhttps://orcid.org/0000-0001-7177-7085Elis de Pellegrin Rossihttps://orcid.org/0000-0002-2175-7083Carla Tatiana Oliveirahttps://orcid.org/0000-0003-2119-7992Paulo de Tarso Roth Dalcinhttps://orcid.org/0000-0002-9774-9135ABSTRACT Objective: There is still limited information on the clinical characteristics and outcomes of cystic fibrosis (CF) patients with COVID-19 in Brazil. The objective of this study was to describe the cumulative incidence of COVID-19 in CF patients, as well as their clinical characteristics and outcomes. Methods: This was a prospective cohort study involving unvaccinated adult CF patients and conducted during the first year of the SARS-CoV-2 pandemic in the city of Porto Alegre, in southern Brazil. The clinical course of the disease was rated on the WHO Ordinal Scale for Clinical Improvement. The primary outcome was the number of incident cases of COVID-19. Results: Between April 30, 2020 and April 29, 2021, 98 CF patients were included in the study. Seventeen patients were diagnosed with COVID-19. For the CF patients, the annual cumulative incidence of COVID-19 was 17.3%, similar to that for the general population, adjusted for age (18.5%). The most common symptoms at diagnosis of COVID-19 were cough (in 59%), dyspnea (in 53%), fatigue (in 53%), and fever (in 47%). Only 6 (35%) of the patients required hospitalization, and 3 (17.6%) required oxygen support. Only 1 patient required mechanical ventilation, having subsequently died. Conclusions: During the first year of the SARS-CoV-2 pandemic in southern Brazil, the cumulative incidence rate of COVID-19 was similar between CF patients and the general population. More than 50% of the CF patients with SARS-CoV-2 infection had a mild clinical presentation, without the need for hospital admission, and almost the entire sample recovered completely from the infection, the exception being 1 patient who had advanced lung disease and who died.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132022000600203&tlng=ptCystic fibrosisCOVID-19SARS-CoV-2 |
| spellingShingle | Cristiane Christ Camargo Letícia Bauer Jacobsen Jaqueline Wilsmann Michelle Nunes Silveira Bruna Ziegler Elis de Pellegrin Rossi Carla Tatiana Oliveira Paulo de Tarso Roth Dalcin Clinical characteristics and outcomes of incident cases of COVID-19 in unvaccinated adult cystic fibrosis patients in southern Brazil: a prospective cohort study conducted during the first year of the COVID-19 pandemic Jornal Brasileiro de Pneumologia Cystic fibrosis COVID-19 SARS-CoV-2 |
| title | Clinical characteristics and outcomes of incident cases of COVID-19 in unvaccinated adult cystic fibrosis patients in southern Brazil: a prospective cohort study conducted during the first year of the COVID-19 pandemic |
| title_full | Clinical characteristics and outcomes of incident cases of COVID-19 in unvaccinated adult cystic fibrosis patients in southern Brazil: a prospective cohort study conducted during the first year of the COVID-19 pandemic |
| title_fullStr | Clinical characteristics and outcomes of incident cases of COVID-19 in unvaccinated adult cystic fibrosis patients in southern Brazil: a prospective cohort study conducted during the first year of the COVID-19 pandemic |
| title_full_unstemmed | Clinical characteristics and outcomes of incident cases of COVID-19 in unvaccinated adult cystic fibrosis patients in southern Brazil: a prospective cohort study conducted during the first year of the COVID-19 pandemic |
| title_short | Clinical characteristics and outcomes of incident cases of COVID-19 in unvaccinated adult cystic fibrosis patients in southern Brazil: a prospective cohort study conducted during the first year of the COVID-19 pandemic |
| title_sort | clinical characteristics and outcomes of incident cases of covid 19 in unvaccinated adult cystic fibrosis patients in southern brazil a prospective cohort study conducted during the first year of the covid 19 pandemic |
| topic | Cystic fibrosis COVID-19 SARS-CoV-2 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132022000600203&tlng=pt |
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