Mitochondrial dysfunction on Leishmania (Leishmania) amazonensis induced by ketoconazole: insights into drug mode of action

Mitochondrial dysfunction on Leishmania (Leishmania) amazonensis induced by ketoconazole: insights into drug mode of action

BACKGROUND Leishmania parasites cause leishmaniasis that range from self-limiting cutaneous lesions to more serious forms of the disease. The search for potential drug targets focusing on biochemical and metabolic pathways revealed the sterol biosynthesis inhibitors (SBIs) as a promising approach....

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Bibliographic Details
Main Authors: Débora Cristina de Oliveira Silva Nunes, Mônica Soares Costa, Luiz Borges Bispo-da-Silva, Eloísa Amália Vieira Ferro, Mariana Alves Pereira Zóia, Luiz Ricardo Goulart, Renata Santos Rodrigues, Veridiana de Melo Rodrigues, Kelly Aparecida Geraldo Yoneyama
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2022-04-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
cutaneous leishmaniasis
ergosterol
mitochondrial damage
sterol biosynthesis inhibitor
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762022000101105&tlng=en

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