Comparison of Clinically used Bilayer Collagen Membrane and Trilayer Collagen Prototype Fixation Stability in Chondral Defects at the Talus: An Experimental Human Specimen Study
Category: Basic Sciences/Biologics Introduction/Purpose: The purpose of this human specimen experimental study was to compare the fixation stability of clinically used bilayer collagen membrane with fibrin glue (Chondro-Gide, Geistlich Pharma AG, Wollhusen, Switzerland) with trilayer collagen protot...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-10-01
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| Series: | Foot & Ankle Orthopaedics |
| Online Access: | https://doi.org/10.1177/2473011420S00403 |
| _version_ | 1828779156170604544 |
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| author | Martinus Richter MD, PhD Alexander Milstrey Stefan Zech MD Angelika Grueter Julia Evers Michael J. Raschke Sabine Ochman |
| author_facet | Martinus Richter MD, PhD Alexander Milstrey Stefan Zech MD Angelika Grueter Julia Evers Michael J. Raschke Sabine Ochman |
| author_sort | Martinus Richter MD, PhD |
| collection | DOAJ |
| description | Category: Basic Sciences/Biologics Introduction/Purpose: The purpose of this human specimen experimental study was to compare the fixation stability of clinically used bilayer collagen membrane with fibrin glue (Chondro-Gide, Geistlich Pharma AG, Wollhusen, Switzerland) with trilayer collagen prototype without fibrin glue in chondral defects at the medial or lateral talar shoulder. Methods: Eleven human specimens were used. The membranes were implanted in standardized chondral defects at the medial and lateral talar shoulder (randomized). All tests were performed in load-control (15kg). Range of motion (ROM) of each ankle was examined individually before testing. The average ROM was 10° dorsalextension (range 0°-20°) and 30° plantarflexion (range 20°-45°). 1,000 testing cycles with the defined ROM were performed. Two independent investigators, blinded to fixation and membrane type, visually assessed the membrane fixation integrity for peripheral detachment, area of defect uncovered, membrane constitution and delamination. Results: The clinically used bilayer collagen membrane plus fibrin glue showed higher fixation stability than the trilayer prototype (all p<0.05). No significant differences occurred between medial and lateral talar shoulder location (all p>0.05). Conclusion: The fixation stability of the trilayer collagen prototype without fibrin glue is lower than of the clinically used bilayer membrane with fibrin glue in chondral defects at the medial and lateral talar shoulder in an experimental human specimen test. Clinical use of trilayer collagen prototype without fibrin glue has to be validated by clinical testing to evaluate if the lower stability of fixation is still sufficient. |
| first_indexed | 2024-12-11T16:56:16Z |
| format | Article |
| id | doaj.art-e0d137c285654e6aae1db948b6126f98 |
| institution | Directory Open Access Journal |
| issn | 2473-0114 |
| language | English |
| last_indexed | 2024-12-11T16:56:16Z |
| publishDate | 2020-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Foot & Ankle Orthopaedics |
| spelling | doaj.art-e0d137c285654e6aae1db948b6126f982022-12-22T00:57:57ZengSAGE PublishingFoot & Ankle Orthopaedics2473-01142020-10-01510.1177/2473011420S00403Comparison of Clinically used Bilayer Collagen Membrane and Trilayer Collagen Prototype Fixation Stability in Chondral Defects at the Talus: An Experimental Human Specimen StudyMartinus Richter MD, PhDAlexander MilstreyStefan Zech MDAngelika GrueterJulia EversMichael J. RaschkeSabine OchmanCategory: Basic Sciences/Biologics Introduction/Purpose: The purpose of this human specimen experimental study was to compare the fixation stability of clinically used bilayer collagen membrane with fibrin glue (Chondro-Gide, Geistlich Pharma AG, Wollhusen, Switzerland) with trilayer collagen prototype without fibrin glue in chondral defects at the medial or lateral talar shoulder. Methods: Eleven human specimens were used. The membranes were implanted in standardized chondral defects at the medial and lateral talar shoulder (randomized). All tests were performed in load-control (15kg). Range of motion (ROM) of each ankle was examined individually before testing. The average ROM was 10° dorsalextension (range 0°-20°) and 30° plantarflexion (range 20°-45°). 1,000 testing cycles with the defined ROM were performed. Two independent investigators, blinded to fixation and membrane type, visually assessed the membrane fixation integrity for peripheral detachment, area of defect uncovered, membrane constitution and delamination. Results: The clinically used bilayer collagen membrane plus fibrin glue showed higher fixation stability than the trilayer prototype (all p<0.05). No significant differences occurred between medial and lateral talar shoulder location (all p>0.05). Conclusion: The fixation stability of the trilayer collagen prototype without fibrin glue is lower than of the clinically used bilayer membrane with fibrin glue in chondral defects at the medial and lateral talar shoulder in an experimental human specimen test. Clinical use of trilayer collagen prototype without fibrin glue has to be validated by clinical testing to evaluate if the lower stability of fixation is still sufficient.https://doi.org/10.1177/2473011420S00403 |
| spellingShingle | Martinus Richter MD, PhD Alexander Milstrey Stefan Zech MD Angelika Grueter Julia Evers Michael J. Raschke Sabine Ochman Comparison of Clinically used Bilayer Collagen Membrane and Trilayer Collagen Prototype Fixation Stability in Chondral Defects at the Talus: An Experimental Human Specimen Study Foot & Ankle Orthopaedics |
| title | Comparison of Clinically used Bilayer Collagen Membrane and Trilayer Collagen Prototype Fixation Stability in Chondral Defects at the Talus: An Experimental Human Specimen Study |
| title_full | Comparison of Clinically used Bilayer Collagen Membrane and Trilayer Collagen Prototype Fixation Stability in Chondral Defects at the Talus: An Experimental Human Specimen Study |
| title_fullStr | Comparison of Clinically used Bilayer Collagen Membrane and Trilayer Collagen Prototype Fixation Stability in Chondral Defects at the Talus: An Experimental Human Specimen Study |
| title_full_unstemmed | Comparison of Clinically used Bilayer Collagen Membrane and Trilayer Collagen Prototype Fixation Stability in Chondral Defects at the Talus: An Experimental Human Specimen Study |
| title_short | Comparison of Clinically used Bilayer Collagen Membrane and Trilayer Collagen Prototype Fixation Stability in Chondral Defects at the Talus: An Experimental Human Specimen Study |
| title_sort | comparison of clinically used bilayer collagen membrane and trilayer collagen prototype fixation stability in chondral defects at the talus an experimental human specimen study |
| url | https://doi.org/10.1177/2473011420S00403 |
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