Persistent severe acute respiratory syndrome coronavirus 2 detection after resolution of coronavirus disease 2019-associated symptoms/signs
There are limited data on the duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in respiratory specimens after resolution of coronavirus disease 2019 (COVID-19)-associated symptoms/signs. We determined duration of SARS-CoV-2 virus shedding in symptomatic patients after rem...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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The Korean Association of Internal Medicine
2020-07-01
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| Series: | The Korean Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://www.kjim.org/upload/pdf/kjim-2020-203.pdf |
| _version_ | 1818643725150060544 |
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| author | Se Yoon Park Soon Gyu Yun Jeong Won Shin Bo Young Lee Hyo-Ju Son Seungjae Lee Eunjung Lee Tae Hyong Kim |
| author_facet | Se Yoon Park Soon Gyu Yun Jeong Won Shin Bo Young Lee Hyo-Ju Son Seungjae Lee Eunjung Lee Tae Hyong Kim |
| author_sort | Se Yoon Park |
| collection | DOAJ |
| description | There are limited data on the duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in respiratory specimens after resolution of coronavirus disease 2019 (COVID-19)-associated symptoms/signs. We determined duration of SARS-CoV-2 virus shedding in symptomatic patients after remission of symptoms. We investigated the duration of SARS-CoV-2 RNA detection using real-time reverse transcriptase polymerase chain reaction for SARS-CoV-2 in nasopharyngeal/oropharyngeal swabs or sputum or saliva. Six patients were included in the final analysis. The median (range) duration of SARS-CoV-2 viral detection after hospitalization was 34 days (22 to 67). After resolution of symptoms/signs, SARS-CoV-2 RNA was detected for median (range) of 26 days (9 to 48). Among the six patients, one had persistent detection of SARS-CoV-2 RNA until day 67 of hospitalization, which was 30 days after symptom resolution. This case represents the longest duration of SARS-CoV-2 detection, and highlights the need for long-term follow up of COVID-19 patients despite resolution of symptoms to confirm SARS-CoV-2 clearance. |
| first_indexed | 2024-12-17T00:03:31Z |
| format | Article |
| id | doaj.art-e0d2de1d6f5b4fd0bed4333c25907ff9 |
| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-12-17T00:03:31Z |
| publishDate | 2020-07-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-e0d2de1d6f5b4fd0bed4333c25907ff92022-12-21T22:11:01ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482020-07-0135479379610.3904/kjim.2020.203170394Persistent severe acute respiratory syndrome coronavirus 2 detection after resolution of coronavirus disease 2019-associated symptoms/signsSe Yoon Park0Soon Gyu Yun1Jeong Won Shin2Bo Young Lee3Hyo-Ju Son4Seungjae Lee5Eunjung Lee6Tae Hyong Kim7 Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea Department of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea Department of Laboratory Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea Division of Allergy and Respiratory Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, KoreaThere are limited data on the duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in respiratory specimens after resolution of coronavirus disease 2019 (COVID-19)-associated symptoms/signs. We determined duration of SARS-CoV-2 virus shedding in symptomatic patients after remission of symptoms. We investigated the duration of SARS-CoV-2 RNA detection using real-time reverse transcriptase polymerase chain reaction for SARS-CoV-2 in nasopharyngeal/oropharyngeal swabs or sputum or saliva. Six patients were included in the final analysis. The median (range) duration of SARS-CoV-2 viral detection after hospitalization was 34 days (22 to 67). After resolution of symptoms/signs, SARS-CoV-2 RNA was detected for median (range) of 26 days (9 to 48). Among the six patients, one had persistent detection of SARS-CoV-2 RNA until day 67 of hospitalization, which was 30 days after symptom resolution. This case represents the longest duration of SARS-CoV-2 detection, and highlights the need for long-term follow up of COVID-19 patients despite resolution of symptoms to confirm SARS-CoV-2 clearance.http://www.kjim.org/upload/pdf/kjim-2020-203.pdfsevere acute respiratory syndrome coronavirus 2covid-19virus shedding |
| spellingShingle | Se Yoon Park Soon Gyu Yun Jeong Won Shin Bo Young Lee Hyo-Ju Son Seungjae Lee Eunjung Lee Tae Hyong Kim Persistent severe acute respiratory syndrome coronavirus 2 detection after resolution of coronavirus disease 2019-associated symptoms/signs The Korean Journal of Internal Medicine severe acute respiratory syndrome coronavirus 2 covid-19 virus shedding |
| title | Persistent severe acute respiratory syndrome coronavirus 2 detection after resolution of coronavirus disease 2019-associated symptoms/signs |
| title_full | Persistent severe acute respiratory syndrome coronavirus 2 detection after resolution of coronavirus disease 2019-associated symptoms/signs |
| title_fullStr | Persistent severe acute respiratory syndrome coronavirus 2 detection after resolution of coronavirus disease 2019-associated symptoms/signs |
| title_full_unstemmed | Persistent severe acute respiratory syndrome coronavirus 2 detection after resolution of coronavirus disease 2019-associated symptoms/signs |
| title_short | Persistent severe acute respiratory syndrome coronavirus 2 detection after resolution of coronavirus disease 2019-associated symptoms/signs |
| title_sort | persistent severe acute respiratory syndrome coronavirus 2 detection after resolution of coronavirus disease 2019 associated symptoms signs |
| topic | severe acute respiratory syndrome coronavirus 2 covid-19 virus shedding |
| url | http://www.kjim.org/upload/pdf/kjim-2020-203.pdf |
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