Nurse-Like Cells and Chronic Lymphocytic Leukemia B Cells: A Mutualistic Crosstalk inside Tissue Microenvironments
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western countries and is an example of hematological disease where cooperation between genetic defects and tumor microenvironmental interaction is involved in pathogenesis. CLL is a disease that is considered as “addicted to the...
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MDPI AG
2021-01-01
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Online Access: | https://www.mdpi.com/2073-4409/10/2/217 |
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author | Stefania Fiorcari Rossana Maffei Claudio Giacinto Atene Leonardo Potenza Mario Luppi Roberto Marasca |
author_facet | Stefania Fiorcari Rossana Maffei Claudio Giacinto Atene Leonardo Potenza Mario Luppi Roberto Marasca |
author_sort | Stefania Fiorcari |
collection | DOAJ |
description | Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western countries and is an example of hematological disease where cooperation between genetic defects and tumor microenvironmental interaction is involved in pathogenesis. CLL is a disease that is considered as “addicted to the host”; indeed, the crosstalk between leukemic cells and the tumor microenvironment is essential for leukemic clone maintenance supporting CLL cells’ survival, proliferation, and protection from drug-induced apoptosis. CLL cells are not innocent bystanders but actively model and manipulate the surrounding microenvironment to their own advantage. Besides the different players involved in this crosstalk, nurse-like cells (NLC) resemble features related to leukemia-associated macrophages with an important function in preserving CLL cell survival and supporting an immunosuppressive microenvironment. This review provides a comprehensive overview of the role played by NLC in creating a nurturing and permissive milieu for CLL cells, illustrating the therapeutic possibilities in order to specifically target and re-educate them. |
first_indexed | 2024-03-09T04:01:57Z |
format | Article |
id | doaj.art-e0d365200c074c4986e00ee724a34463 |
institution | Directory Open Access Journal |
issn | 2073-4409 |
language | English |
last_indexed | 2024-03-09T04:01:57Z |
publishDate | 2021-01-01 |
publisher | MDPI AG |
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series | Cells |
spelling | doaj.art-e0d365200c074c4986e00ee724a344632023-12-03T14:13:02ZengMDPI AGCells2073-44092021-01-0110221710.3390/cells10020217Nurse-Like Cells and Chronic Lymphocytic Leukemia B Cells: A Mutualistic Crosstalk inside Tissue MicroenvironmentsStefania Fiorcari0Rossana Maffei1Claudio Giacinto Atene2Leonardo Potenza3Mario Luppi4Roberto Marasca5Department of Medical and Surgical Sciences, Section of Hematology, University of Modena and Reggio Emilia, 41124 Modena, ItalyDepartment of Medical and Surgical Sciences, Section of Hematology, University of Modena and Reggio Emilia, 41124 Modena, ItalyDepartment of Medical and Surgical Sciences, Section of Hematology, University of Modena and Reggio Emilia, 41124 Modena, ItalyDepartment of Medical and Surgical Sciences, Section of Hematology, University of Modena and Reggio Emilia, 41124 Modena, ItalyDepartment of Medical and Surgical Sciences, Section of Hematology, University of Modena and Reggio Emilia, 41124 Modena, ItalyDepartment of Medical and Surgical Sciences, Section of Hematology, University of Modena and Reggio Emilia, 41124 Modena, ItalyChronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western countries and is an example of hematological disease where cooperation between genetic defects and tumor microenvironmental interaction is involved in pathogenesis. CLL is a disease that is considered as “addicted to the host”; indeed, the crosstalk between leukemic cells and the tumor microenvironment is essential for leukemic clone maintenance supporting CLL cells’ survival, proliferation, and protection from drug-induced apoptosis. CLL cells are not innocent bystanders but actively model and manipulate the surrounding microenvironment to their own advantage. Besides the different players involved in this crosstalk, nurse-like cells (NLC) resemble features related to leukemia-associated macrophages with an important function in preserving CLL cell survival and supporting an immunosuppressive microenvironment. This review provides a comprehensive overview of the role played by NLC in creating a nurturing and permissive milieu for CLL cells, illustrating the therapeutic possibilities in order to specifically target and re-educate them.https://www.mdpi.com/2073-4409/10/2/217CLLmicroenvironmentnurse-like cells |
spellingShingle | Stefania Fiorcari Rossana Maffei Claudio Giacinto Atene Leonardo Potenza Mario Luppi Roberto Marasca Nurse-Like Cells and Chronic Lymphocytic Leukemia B Cells: A Mutualistic Crosstalk inside Tissue Microenvironments Cells CLL microenvironment nurse-like cells |
title | Nurse-Like Cells and Chronic Lymphocytic Leukemia B Cells: A Mutualistic Crosstalk inside Tissue Microenvironments |
title_full | Nurse-Like Cells and Chronic Lymphocytic Leukemia B Cells: A Mutualistic Crosstalk inside Tissue Microenvironments |
title_fullStr | Nurse-Like Cells and Chronic Lymphocytic Leukemia B Cells: A Mutualistic Crosstalk inside Tissue Microenvironments |
title_full_unstemmed | Nurse-Like Cells and Chronic Lymphocytic Leukemia B Cells: A Mutualistic Crosstalk inside Tissue Microenvironments |
title_short | Nurse-Like Cells and Chronic Lymphocytic Leukemia B Cells: A Mutualistic Crosstalk inside Tissue Microenvironments |
title_sort | nurse like cells and chronic lymphocytic leukemia b cells a mutualistic crosstalk inside tissue microenvironments |
topic | CLL microenvironment nurse-like cells |
url | https://www.mdpi.com/2073-4409/10/2/217 |
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