Recent Microdevice-Based Aptamer Sensors
Since the systematic evolution of ligands by exponential enrichment (SELEX) method was developed, aptamers have made significant contributions as bio-recognition sensors. Microdevice systems allow for low reagent consumption, high-throughput of samples, and disposability. Due to these advantages, th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-04-01
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| Series: | Micromachines |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-666X/9/5/202 |
| _version_ | 1818998922171908096 |
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| author | Donny Nugraha Mazaafrianto Masatoshi Maeki Akihiko Ishida Hirofumi Tani Manabu Tokeshi |
| author_facet | Donny Nugraha Mazaafrianto Masatoshi Maeki Akihiko Ishida Hirofumi Tani Manabu Tokeshi |
| author_sort | Donny Nugraha Mazaafrianto |
| collection | DOAJ |
| description | Since the systematic evolution of ligands by exponential enrichment (SELEX) method was developed, aptamers have made significant contributions as bio-recognition sensors. Microdevice systems allow for low reagent consumption, high-throughput of samples, and disposability. Due to these advantages, there has been an increasing demand to develop microfluidic-based aptasensors for analytical technique applications. This review introduces the principal concepts of aptasensors and then presents some advanced applications of microdevice-based aptasensors on several platforms. Highly sensitive detection techniques, such as electrochemical and optical detection, have been integrated into lab-on-a-chip devices and researchers have moved towards the goal of establishing point-of-care diagnoses for target analyses. |
| first_indexed | 2024-12-20T22:09:13Z |
| format | Article |
| id | doaj.art-e0d3adb3414d43799486395a41d5b81b |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-12-20T22:09:13Z |
| publishDate | 2018-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-e0d3adb3414d43799486395a41d5b81b2022-12-21T19:25:12ZengMDPI AGMicromachines2072-666X2018-04-019520210.3390/mi9050202mi9050202Recent Microdevice-Based Aptamer SensorsDonny Nugraha Mazaafrianto0Masatoshi Maeki1Akihiko Ishida2Hirofumi Tani3Manabu Tokeshi4Graduate School of Chemical Sciences and Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo 060-8628, JapanDivision of Applied Chemistry, Faculty of Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo 060-8628, JapanDivision of Applied Chemistry, Faculty of Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo 060-8628, JapanDivision of Applied Chemistry, Faculty of Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo 060-8628, JapanDivision of Applied Chemistry, Faculty of Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo 060-8628, JapanSince the systematic evolution of ligands by exponential enrichment (SELEX) method was developed, aptamers have made significant contributions as bio-recognition sensors. Microdevice systems allow for low reagent consumption, high-throughput of samples, and disposability. Due to these advantages, there has been an increasing demand to develop microfluidic-based aptasensors for analytical technique applications. This review introduces the principal concepts of aptasensors and then presents some advanced applications of microdevice-based aptasensors on several platforms. Highly sensitive detection techniques, such as electrochemical and optical detection, have been integrated into lab-on-a-chip devices and researchers have moved towards the goal of establishing point-of-care diagnoses for target analyses.http://www.mdpi.com/2072-666X/9/5/202microdeviceaptamerbiosensorSELEXlab-on-chippoint-of-care |
| spellingShingle | Donny Nugraha Mazaafrianto Masatoshi Maeki Akihiko Ishida Hirofumi Tani Manabu Tokeshi Recent Microdevice-Based Aptamer Sensors Micromachines microdevice aptamer biosensor SELEX lab-on-chip point-of-care |
| title | Recent Microdevice-Based Aptamer Sensors |
| title_full | Recent Microdevice-Based Aptamer Sensors |
| title_fullStr | Recent Microdevice-Based Aptamer Sensors |
| title_full_unstemmed | Recent Microdevice-Based Aptamer Sensors |
| title_short | Recent Microdevice-Based Aptamer Sensors |
| title_sort | recent microdevice based aptamer sensors |
| topic | microdevice aptamer biosensor SELEX lab-on-chip point-of-care |
| url | http://www.mdpi.com/2072-666X/9/5/202 |
| work_keys_str_mv | AT donnynugrahamazaafrianto recentmicrodevicebasedaptamersensors AT masatoshimaeki recentmicrodevicebasedaptamersensors AT akihikoishida recentmicrodevicebasedaptamersensors AT hirofumitani recentmicrodevicebasedaptamersensors AT manabutokeshi recentmicrodevicebasedaptamersensors |