CNTF and Nrf2 Are Coordinately Involved in Regulating Self-Renewal and Differentiation of Neural Stem Cell during Embryonic Development
Summary: There is high risk of fetal neurodevelopmental defects in pregestational diabetes mellitus (PGDM). However, the effective mechanism of hyperglycemia-induced neurodevelopmental negative effects, including neural stem cell self-renewal and differentiation, still remains obscure. Neuropoietic...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-09-01
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| Series: | iScience |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004219302652 |
| _version_ | 1818313031160954880 |
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| author | Zhen-Peng Si Guang Wang Sha-Sha Han Ya Jin Yu-Xuan Hu Mei-Yao He Beate Brand-Saberi Xuesong Yang Guo-Sheng Liu |
| author_facet | Zhen-Peng Si Guang Wang Sha-Sha Han Ya Jin Yu-Xuan Hu Mei-Yao He Beate Brand-Saberi Xuesong Yang Guo-Sheng Liu |
| author_sort | Zhen-Peng Si |
| collection | DOAJ |
| description | Summary: There is high risk of fetal neurodevelopmental defects in pregestational diabetes mellitus (PGDM). However, the effective mechanism of hyperglycemia-induced neurodevelopmental negative effects, including neural stem cell self-renewal and differentiation, still remains obscure. Neuropoietic cytokines have been shown to play a vital part during nervous system development and in the coordination of neurons and gliocytes. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) dysfunction might be related to a reduction of self-protective response in brain malformation induced by hyperglycemia. We therefore evaluated the role of Nrf2 and neuropoietic cytokines in fetal neurodevelopmental defects induced by PGDM and determined the mechanisms involved. Our data reveal that PGDM dramatically impairs the developmental switch of neural stem cells from neurogenesis to gliogenesis, principally under the cooperative mediation of neuropoietic cytokine CNTF and Nrf2 antioxidative signaling. This indicates that CNTF and Nrf2 could be potentially used in the prevention or therapy of neurodevelopmental defects of PGDM offspring. : Molecular Neuroscience; Developmental Neuroscience; Diabetology Subject Areas: Molecular Neuroscience, Developmental Neuroscience, Diabetology |
| first_indexed | 2024-12-13T08:27:16Z |
| format | Article |
| id | doaj.art-e0d3d40f63af4725b138c5a084d9415d |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-13T08:27:16Z |
| publishDate | 2019-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-e0d3d40f63af4725b138c5a084d9415d2022-12-21T23:53:52ZengElsevieriScience2589-00422019-09-0119303315CNTF and Nrf2 Are Coordinately Involved in Regulating Self-Renewal and Differentiation of Neural Stem Cell during Embryonic DevelopmentZhen-Peng Si0Guang Wang1Sha-Sha Han2Ya Jin3Yu-Xuan Hu4Mei-Yao He5Beate Brand-Saberi6Xuesong Yang7Guo-Sheng Liu8Department of Pediatrics, The First Affiliated Hospital, Jinan University, Guangzhou 510630, ChinaInternational Joint Laboratory for Embryonic Development & Prenatal Medicine, Division of Histology and Embryology, Medical College, Jinan University, Guangzhou 510632, ChinaDepartment of Pediatrics, The First Affiliated Hospital, Jinan University, Guangzhou 510630, ChinaDepartment of Pediatrics, The First Affiliated Hospital, Jinan University, Guangzhou 510630, ChinaInternational Joint Laboratory for Embryonic Development & Prenatal Medicine, Division of Histology and Embryology, Medical College, Jinan University, Guangzhou 510632, ChinaDepartment of Pediatrics, The First Affiliated Hospital, Jinan University, Guangzhou 510630, ChinaDepartment of Anatomy and Molecular Embryology, Ruhr University Bochum, Bochum, GermanyInternational Joint Laboratory for Embryonic Development & Prenatal Medicine, Division of Histology and Embryology, Medical College, Jinan University, Guangzhou 510632, China; Key Laboratory for Regenerative Medicine of the Ministry of Education, Jinan University, Guangzhou 510632, China; Corresponding authorDepartment of Pediatrics, The First Affiliated Hospital, Jinan University, Guangzhou 510630, China; Corresponding authorSummary: There is high risk of fetal neurodevelopmental defects in pregestational diabetes mellitus (PGDM). However, the effective mechanism of hyperglycemia-induced neurodevelopmental negative effects, including neural stem cell self-renewal and differentiation, still remains obscure. Neuropoietic cytokines have been shown to play a vital part during nervous system development and in the coordination of neurons and gliocytes. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) dysfunction might be related to a reduction of self-protective response in brain malformation induced by hyperglycemia. We therefore evaluated the role of Nrf2 and neuropoietic cytokines in fetal neurodevelopmental defects induced by PGDM and determined the mechanisms involved. Our data reveal that PGDM dramatically impairs the developmental switch of neural stem cells from neurogenesis to gliogenesis, principally under the cooperative mediation of neuropoietic cytokine CNTF and Nrf2 antioxidative signaling. This indicates that CNTF and Nrf2 could be potentially used in the prevention or therapy of neurodevelopmental defects of PGDM offspring. : Molecular Neuroscience; Developmental Neuroscience; Diabetology Subject Areas: Molecular Neuroscience, Developmental Neuroscience, Diabetologyhttp://www.sciencedirect.com/science/article/pii/S2589004219302652 |
| spellingShingle | Zhen-Peng Si Guang Wang Sha-Sha Han Ya Jin Yu-Xuan Hu Mei-Yao He Beate Brand-Saberi Xuesong Yang Guo-Sheng Liu CNTF and Nrf2 Are Coordinately Involved in Regulating Self-Renewal and Differentiation of Neural Stem Cell during Embryonic Development iScience |
| title | CNTF and Nrf2 Are Coordinately Involved in Regulating Self-Renewal and Differentiation of Neural Stem Cell during Embryonic Development |
| title_full | CNTF and Nrf2 Are Coordinately Involved in Regulating Self-Renewal and Differentiation of Neural Stem Cell during Embryonic Development |
| title_fullStr | CNTF and Nrf2 Are Coordinately Involved in Regulating Self-Renewal and Differentiation of Neural Stem Cell during Embryonic Development |
| title_full_unstemmed | CNTF and Nrf2 Are Coordinately Involved in Regulating Self-Renewal and Differentiation of Neural Stem Cell during Embryonic Development |
| title_short | CNTF and Nrf2 Are Coordinately Involved in Regulating Self-Renewal and Differentiation of Neural Stem Cell during Embryonic Development |
| title_sort | cntf and nrf2 are coordinately involved in regulating self renewal and differentiation of neural stem cell during embryonic development |
| url | http://www.sciencedirect.com/science/article/pii/S2589004219302652 |
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