Use of Parathyroid Hormone and Rehabilitation Reduces Subsequent Vertebral Body Fractures after Balloon Kyphoplasty
Study Design Retrospective cohort study. Purpose To evaluate the efficacy of our current prophylactic strategy by investigating the incidence of subsequent vertebral body fractures (SVBFs) following balloon kyphoplasty (BKP). Overview of Literature Although extensive studies have investigated the ri...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Spine Society
2022-06-01
|
| Series: | Asian Spine Journal |
| Subjects: | |
| Online Access: | http://www.asianspinejournal.org/upload/pdf/asj-2020-0608.pdf |
| _version_ | 1828327078326435840 |
|---|---|
| author | Masaki Ueno Emi Toriumi Aki Yoshii Yuki Tabata Takeshi Furudate Yusuke Tajima |
| author_facet | Masaki Ueno Emi Toriumi Aki Yoshii Yuki Tabata Takeshi Furudate Yusuke Tajima |
| author_sort | Masaki Ueno |
| collection | DOAJ |
| description | Study Design Retrospective cohort study. Purpose To evaluate the efficacy of our current prophylactic strategy by investigating the incidence of subsequent vertebral body fractures (SVBFs) following balloon kyphoplasty (BKP). Overview of Literature Although extensive studies have investigated the risk factors for SVBFs after BKP, few have reported on postoperative therapies to prevent SVBFs and have evaluated their effectiveness. Methods This study enrolled 273 patients who underwent an initial BKP. To treat osteoporosis, parathyroid hormone (PTH) administration was started 1–2 weeks before BKP and continued for at least 6 months postoperatively. Corsets were applied for 3 months after the procedure. Rehabilitative interventions, including hip range-of-motion training, muscle strengthening exercises, and motion/posture instruction, were started from the preoperative assessment time point and resumed 3 hours postoperatively. Corsets were used in all patients. Therefore, no grouping based on corset use was performed. PTH was used in 180 patients, and they were divided into the following two groups: PTH user group and PTH nonuser group. Rehabilitative interventions were provided to all patients for a median duration of 17 days. Patients who underwent rehabilitative intervention for <17 and ≥17 days were included in the short-term and long-term intervention groups, respectively. The incidences of SVBFs for these four groups were compared. Results SVBF occurred in 29 patients (10.6%). The SVBF incidence among patients who were prescribed all three prophylactic measures was 6.2%. The PTH user group had a significantly lower incidence of distant vertebral body fractures as compared to the PTH nonuser group. The long-term rehabilitation group had a significantly lower incidence of SVBFs and adjacent vertebral body fractures within 50 postoperative days than the short-term group. Conclusions A 17-day or longer rehabilitative intervention may lower the risk of early adjacent vertebral body fractures, and the use of PTH may reduce the risk of distant vertebral body fractures. |
| first_indexed | 2024-04-13T19:49:36Z |
| format | Article |
| id | doaj.art-e0d5249c3bb6486ab53bba1c069ea497 |
| institution | Directory Open Access Journal |
| issn | 1976-1902 1976-7846 |
| language | English |
| last_indexed | 2024-04-13T19:49:36Z |
| publishDate | 2022-06-01 |
| publisher | Korean Spine Society |
| record_format | Article |
| series | Asian Spine Journal |
| spelling | doaj.art-e0d5249c3bb6486ab53bba1c069ea4972022-12-22T02:32:35ZengKorean Spine SocietyAsian Spine Journal1976-19021976-78462022-06-0116343243910.31616/asj.2020.06081370Use of Parathyroid Hormone and Rehabilitation Reduces Subsequent Vertebral Body Fractures after Balloon KyphoplastyMasaki Ueno0Emi Toriumi1Aki Yoshii2Yuki Tabata3Takeshi Furudate4Yusuke Tajima5 Department of Orthopaedic Surgery, Machida Keisen Hospital, Machida, Japan Department of Rehabilitation, Machida Keisen Hospital, Machida, Japan Department of Rehabilitation, Machida Keisen Hospital, Machida, Japan Department of Rehabilitation, Machida Keisen Hospital, Machida, Japan Department of Orthopaedic Surgery, Machida Keisen Hospital, Machida, Japan Department of Orthopaedic Surgery, Machida Keisen Hospital, Machida, JapanStudy Design Retrospective cohort study. Purpose To evaluate the efficacy of our current prophylactic strategy by investigating the incidence of subsequent vertebral body fractures (SVBFs) following balloon kyphoplasty (BKP). Overview of Literature Although extensive studies have investigated the risk factors for SVBFs after BKP, few have reported on postoperative therapies to prevent SVBFs and have evaluated their effectiveness. Methods This study enrolled 273 patients who underwent an initial BKP. To treat osteoporosis, parathyroid hormone (PTH) administration was started 1–2 weeks before BKP and continued for at least 6 months postoperatively. Corsets were applied for 3 months after the procedure. Rehabilitative interventions, including hip range-of-motion training, muscle strengthening exercises, and motion/posture instruction, were started from the preoperative assessment time point and resumed 3 hours postoperatively. Corsets were used in all patients. Therefore, no grouping based on corset use was performed. PTH was used in 180 patients, and they were divided into the following two groups: PTH user group and PTH nonuser group. Rehabilitative interventions were provided to all patients for a median duration of 17 days. Patients who underwent rehabilitative intervention for <17 and ≥17 days were included in the short-term and long-term intervention groups, respectively. The incidences of SVBFs for these four groups were compared. Results SVBF occurred in 29 patients (10.6%). The SVBF incidence among patients who were prescribed all three prophylactic measures was 6.2%. The PTH user group had a significantly lower incidence of distant vertebral body fractures as compared to the PTH nonuser group. The long-term rehabilitation group had a significantly lower incidence of SVBFs and adjacent vertebral body fractures within 50 postoperative days than the short-term group. Conclusions A 17-day or longer rehabilitative intervention may lower the risk of early adjacent vertebral body fractures, and the use of PTH may reduce the risk of distant vertebral body fractures.http://www.asianspinejournal.org/upload/pdf/asj-2020-0608.pdfballoon vertebroplastycompression fracturerehabilitationparathyroid hormoneteriparatide |
| spellingShingle | Masaki Ueno Emi Toriumi Aki Yoshii Yuki Tabata Takeshi Furudate Yusuke Tajima Use of Parathyroid Hormone and Rehabilitation Reduces Subsequent Vertebral Body Fractures after Balloon Kyphoplasty Asian Spine Journal balloon vertebroplasty compression fracture rehabilitation parathyroid hormone teriparatide |
| title | Use of Parathyroid Hormone and Rehabilitation Reduces Subsequent Vertebral Body Fractures after Balloon Kyphoplasty |
| title_full | Use of Parathyroid Hormone and Rehabilitation Reduces Subsequent Vertebral Body Fractures after Balloon Kyphoplasty |
| title_fullStr | Use of Parathyroid Hormone and Rehabilitation Reduces Subsequent Vertebral Body Fractures after Balloon Kyphoplasty |
| title_full_unstemmed | Use of Parathyroid Hormone and Rehabilitation Reduces Subsequent Vertebral Body Fractures after Balloon Kyphoplasty |
| title_short | Use of Parathyroid Hormone and Rehabilitation Reduces Subsequent Vertebral Body Fractures after Balloon Kyphoplasty |
| title_sort | use of parathyroid hormone and rehabilitation reduces subsequent vertebral body fractures after balloon kyphoplasty |
| topic | balloon vertebroplasty compression fracture rehabilitation parathyroid hormone teriparatide |
| url | http://www.asianspinejournal.org/upload/pdf/asj-2020-0608.pdf |
| work_keys_str_mv | AT masakiueno useofparathyroidhormoneandrehabilitationreducessubsequentvertebralbodyfracturesafterballoonkyphoplasty AT emitoriumi useofparathyroidhormoneandrehabilitationreducessubsequentvertebralbodyfracturesafterballoonkyphoplasty AT akiyoshii useofparathyroidhormoneandrehabilitationreducessubsequentvertebralbodyfracturesafterballoonkyphoplasty AT yukitabata useofparathyroidhormoneandrehabilitationreducessubsequentvertebralbodyfracturesafterballoonkyphoplasty AT takeshifurudate useofparathyroidhormoneandrehabilitationreducessubsequentvertebralbodyfracturesafterballoonkyphoplasty AT yusuketajima useofparathyroidhormoneandrehabilitationreducessubsequentvertebralbodyfracturesafterballoonkyphoplasty |