Genetic Aspects of Corneal Sequestra in a Population of Persian, Himalayan and Exotic Cats
Corneal sequestra are ophthalmic lesions that are remarkably common in Persian, Himalayan and exotic cats. In this study, the genetic aspects of this disease were investigated in a population of cats originating from a single cattery. Odds ratios were calculated for parents with affected offspring....
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MDPI AG
2022-08-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/12/15/2008 |
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| author | Tom Schipper Goedele Storms Gerlinde Janssens Sabine Schoofs Eveline Capiau Dieter Verdonck Pascale Smets Luc J. Peelman Bart J. G. Broeckx |
| author_facet | Tom Schipper Goedele Storms Gerlinde Janssens Sabine Schoofs Eveline Capiau Dieter Verdonck Pascale Smets Luc J. Peelman Bart J. G. Broeckx |
| author_sort | Tom Schipper |
| collection | DOAJ |
| description | Corneal sequestra are ophthalmic lesions that are remarkably common in Persian, Himalayan and exotic cats. In this study, the genetic aspects of this disease were investigated in a population of cats originating from a single cattery. Odds ratios were calculated for parents with affected offspring. The heritability of (owner-reported) corneal sequestra was estimated with a Markov chain Monte Carlo procedure. Well-phenotyped cases and controls were used for a genome-wide association study. Data from 692 cats originating from the cattery, of which 61 were affected, were used. Cats from two specific mothers had significantly higher odds of developing corneal sequestra, but no significant effect of the fathers was found (after correction for the mothers). The heritability of corneal sequestra was estimated to be 0.96. A genome-wide association study with 14 cases and 10 controls did not reveal an associated chromosomal region. The large effect that genetic factors had on the development of corneal sequestra in this study suggests that selective breeding could be an effective way to reduce the prevalence of this condition in these cat breeds. |
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| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T05:39:35Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
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| series | Animals |
| spelling | doaj.art-e0d55ab7b1134cfc80df6a9ec6d327042023-12-03T12:26:27ZengMDPI AGAnimals2076-26152022-08-011215200810.3390/ani12152008Genetic Aspects of Corneal Sequestra in a Population of Persian, Himalayan and Exotic CatsTom Schipper0Goedele Storms1Gerlinde Janssens2Sabine Schoofs3Eveline Capiau4Dieter Verdonck5Pascale Smets6Luc J. Peelman7Bart J. G. Broeckx8Department of Veterinary and Biosciences, Ghent University, B-9820 Merelbeke, BelgiumVeterinary Practice Kleidal, Kleidaallaan 74, B-2620 Hemiksem, BelgiumVeterinary Practice Kleidal, Kleidaallaan 74, B-2620 Hemiksem, BelgiumVeterinary Practice Clos Fleuri, Oude Gaversesteenweg 35, B-9820 Merelbeke, BelgiumVeterinary Practice Eveline Capiau, Ten Eekhovelei 239, B-2100 Deurne, BelgiumSmall Animal Department, Ghent University, B-9820 Merelbeke, BelgiumSmall Animal Department, Ghent University, B-9820 Merelbeke, BelgiumDepartment of Veterinary and Biosciences, Ghent University, B-9820 Merelbeke, BelgiumDepartment of Veterinary and Biosciences, Ghent University, B-9820 Merelbeke, BelgiumCorneal sequestra are ophthalmic lesions that are remarkably common in Persian, Himalayan and exotic cats. In this study, the genetic aspects of this disease were investigated in a population of cats originating from a single cattery. Odds ratios were calculated for parents with affected offspring. The heritability of (owner-reported) corneal sequestra was estimated with a Markov chain Monte Carlo procedure. Well-phenotyped cases and controls were used for a genome-wide association study. Data from 692 cats originating from the cattery, of which 61 were affected, were used. Cats from two specific mothers had significantly higher odds of developing corneal sequestra, but no significant effect of the fathers was found (after correction for the mothers). The heritability of corneal sequestra was estimated to be 0.96. A genome-wide association study with 14 cases and 10 controls did not reveal an associated chromosomal region. The large effect that genetic factors had on the development of corneal sequestra in this study suggests that selective breeding could be an effective way to reduce the prevalence of this condition in these cat breeds.https://www.mdpi.com/2076-2615/12/15/2008corneal sequestrumheritabilityfelis catusGWASbreeding advice |
| spellingShingle | Tom Schipper Goedele Storms Gerlinde Janssens Sabine Schoofs Eveline Capiau Dieter Verdonck Pascale Smets Luc J. Peelman Bart J. G. Broeckx Genetic Aspects of Corneal Sequestra in a Population of Persian, Himalayan and Exotic Cats Animals corneal sequestrum heritability felis catus GWAS breeding advice |
| title | Genetic Aspects of Corneal Sequestra in a Population of Persian, Himalayan and Exotic Cats |
| title_full | Genetic Aspects of Corneal Sequestra in a Population of Persian, Himalayan and Exotic Cats |
| title_fullStr | Genetic Aspects of Corneal Sequestra in a Population of Persian, Himalayan and Exotic Cats |
| title_full_unstemmed | Genetic Aspects of Corneal Sequestra in a Population of Persian, Himalayan and Exotic Cats |
| title_short | Genetic Aspects of Corneal Sequestra in a Population of Persian, Himalayan and Exotic Cats |
| title_sort | genetic aspects of corneal sequestra in a population of persian himalayan and exotic cats |
| topic | corneal sequestrum heritability felis catus GWAS breeding advice |
| url | https://www.mdpi.com/2076-2615/12/15/2008 |
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