Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis
Cell migration regulates diverse (patho)physiological processes, including cancer metastasis. Here the authors show that the chloride ion channel SWELL1 and the ion exchanger NHE1 are preferentially enriched at the trailing and leading edges, respectively, of migrating cells and regulate cell volume...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33683-1 |
| _version_ | 1797985992232140800 |
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| author | Yuqi Zhang Yizeng Li Keyata N. Thompson Konstantin Stoletov Qinling Yuan Kaustav Bera Se Jong Lee Runchen Zhao Alexander Kiepas Yao Wang Panagiotis Mistriotis Selma A. Serra John D. Lewis Miguel A. Valverde Stuart S. Martin Sean X. Sun Konstantinos Konstantopoulos |
| author_facet | Yuqi Zhang Yizeng Li Keyata N. Thompson Konstantin Stoletov Qinling Yuan Kaustav Bera Se Jong Lee Runchen Zhao Alexander Kiepas Yao Wang Panagiotis Mistriotis Selma A. Serra John D. Lewis Miguel A. Valverde Stuart S. Martin Sean X. Sun Konstantinos Konstantopoulos |
| author_sort | Yuqi Zhang |
| collection | DOAJ |
| description | Cell migration regulates diverse (patho)physiological processes, including cancer metastasis. Here the authors show that the chloride ion channel SWELL1 and the ion exchanger NHE1 are preferentially enriched at the trailing and leading edges, respectively, of migrating cells and regulate cell volume to propel confined cells, favouring breast cancer cell extravasation and metastasis. |
| first_indexed | 2024-04-11T07:25:50Z |
| format | Article |
| id | doaj.art-e0d59226dc564a198172e55e93cfb59f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T07:25:50Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e0d59226dc564a198172e55e93cfb59f2022-12-22T04:37:04ZengNature PortfolioNature Communications2041-17232022-10-0113111710.1038/s41467-022-33683-1Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasisYuqi Zhang0Yizeng Li1Keyata N. Thompson2Konstantin Stoletov3Qinling Yuan4Kaustav Bera5Se Jong Lee6Runchen Zhao7Alexander Kiepas8Yao Wang9Panagiotis Mistriotis10Selma A. Serra11John D. Lewis12Miguel A. Valverde13Stuart S. Martin14Sean X. Sun15Konstantinos Konstantopoulos16Department of Chemical and Biomolecular Engineering, The Johns Hopkins UniversityDepartment of Biomedical Engineering, Binghamton UniversityMarlene and Stewart Greenebaum National Cancer Institute Comprehensive Cancer Center, University of Maryland School of MedicineDepartment of Oncology, University of AlbertaDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins UniversityDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins UniversityDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins UniversityDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins UniversityDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins UniversityDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins UniversityDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins UniversityLaboratory of Molecular Physiology, Department of Experimental and Health Sciences, Universitat Pompeu FabraDepartment of Oncology, University of AlbertaLaboratory of Molecular Physiology, Department of Experimental and Health Sciences, Universitat Pompeu FabraMarlene and Stewart Greenebaum National Cancer Institute Comprehensive Cancer Center, University of Maryland School of MedicineDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins UniversityDepartment of Chemical and Biomolecular Engineering, The Johns Hopkins UniversityCell migration regulates diverse (patho)physiological processes, including cancer metastasis. Here the authors show that the chloride ion channel SWELL1 and the ion exchanger NHE1 are preferentially enriched at the trailing and leading edges, respectively, of migrating cells and regulate cell volume to propel confined cells, favouring breast cancer cell extravasation and metastasis.https://doi.org/10.1038/s41467-022-33683-1 |
| spellingShingle | Yuqi Zhang Yizeng Li Keyata N. Thompson Konstantin Stoletov Qinling Yuan Kaustav Bera Se Jong Lee Runchen Zhao Alexander Kiepas Yao Wang Panagiotis Mistriotis Selma A. Serra John D. Lewis Miguel A. Valverde Stuart S. Martin Sean X. Sun Konstantinos Konstantopoulos Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis Nature Communications |
| title | Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis |
| title_full | Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis |
| title_fullStr | Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis |
| title_full_unstemmed | Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis |
| title_short | Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis |
| title_sort | polarized nhe1 and swell1 regulate migration direction efficiency and metastasis |
| url | https://doi.org/10.1038/s41467-022-33683-1 |
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