Numerical simulation of the functionality of a stent structure for venous valve prostheses
Chronic venous insufficiency (CVI) is a common disease characterized by impaired venous drainage leading to congestion in the lower limbs. Currently, there are no artificial or biological venous valve prostheses commercially available. Previous minimally invasive design concepts failed to achieve su...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2019-09-01
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| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2019-0120 |
| _version_ | 1811246863342370816 |
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| author | Schubert Julia Schümann Kerstin Kischkel Sabine Schmidt Wolfram Grabow Niels Stiehm Michael Pfensig Sylvia Schmitz Klaus-Peter Keiler Jonas Wree Andreas |
| author_facet | Schubert Julia Schümann Kerstin Kischkel Sabine Schmidt Wolfram Grabow Niels Stiehm Michael Pfensig Sylvia Schmitz Klaus-Peter Keiler Jonas Wree Andreas |
| author_sort | Schubert Julia |
| collection | DOAJ |
| description | Chronic venous insufficiency (CVI) is a common disease characterized by impaired venous drainage leading to congestion in the lower limbs. Currently, there are no artificial or biological venous valve prostheses commercially available. Previous minimally invasive design concepts failed to achieve sufficient long term results in animal or in vitro studies. The aim was to implement structural numerical simulation of clinically relevant loading cases for minimally invasive implantable venous valve prostheses. A bicuspid valve design was chosen as it showed superior results compared to tricuspid valves in previous studies. The selfexpanding support structure was developed by using diamond-shaped elements. Using finite-element analysis (FEA), various loading cases, including expansion and crimping of the stent structure and the release into a venous vessel, were simulated. A hyperelastic constitutive law for the vascular model was generated from uniaxial tensile test data of unfixated human vein walls. This study also compared numerical and experimental results regarding compliance and tensile tests to validate the vein material model. The calculated performance concerning expansion and crimping, as well as the release of the stent into a venous vessel, demonstrated the suitability of the stent design for minimally invasive application. |
| first_indexed | 2024-04-12T15:00:28Z |
| format | Article |
| id | doaj.art-e0d719e9a1d84fdf82436cf8aa48adbd |
| institution | Directory Open Access Journal |
| issn | 2364-5504 |
| language | English |
| last_indexed | 2024-04-12T15:00:28Z |
| publishDate | 2019-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj.art-e0d719e9a1d84fdf82436cf8aa48adbd2022-12-22T03:28:06ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042019-09-015147747910.1515/cdbme-2019-0120cdbme-2019-0120Numerical simulation of the functionality of a stent structure for venous valve prosthesesSchubert Julia0Schümann Kerstin1Kischkel Sabine2Schmidt Wolfram3Grabow Niels4Stiehm Michael5Pfensig Sylvia6Schmitz Klaus-Peter7Keiler Jonas8Wree Andreas9Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich- Barnewitz-Str. 4, Rostock-Warnemünde, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemünde, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemünde, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemünde, GermanyInstitute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, 18119 Rostock-Warnemünde, GermanyInstitute for ImplantTechnology and Biomaterials – IIB e.V. and Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, RostockWarnemünde, GermanyInstitute for ImplantTechnology and Biomaterials - IIB e.V. and Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, RostockWarnemünde, GermanyInstitute for ImplantTechnology and Biomaterials - IIB e.V. and Institute for Biomedical Engineering, Rostock University Medical Center, Friedrich-Barnewitz-Str. 4, RostockWarnemünde, GermanyDepartment of Anatomy, Rostock University Medical Center, Gertrudenstr. 9,Rostock, GermanyDepartment of Anatomy, Rostock University Medical Center, Gertrudenstr. 9,Rostock, GermanyChronic venous insufficiency (CVI) is a common disease characterized by impaired venous drainage leading to congestion in the lower limbs. Currently, there are no artificial or biological venous valve prostheses commercially available. Previous minimally invasive design concepts failed to achieve sufficient long term results in animal or in vitro studies. The aim was to implement structural numerical simulation of clinically relevant loading cases for minimally invasive implantable venous valve prostheses. A bicuspid valve design was chosen as it showed superior results compared to tricuspid valves in previous studies. The selfexpanding support structure was developed by using diamond-shaped elements. Using finite-element analysis (FEA), various loading cases, including expansion and crimping of the stent structure and the release into a venous vessel, were simulated. A hyperelastic constitutive law for the vascular model was generated from uniaxial tensile test data of unfixated human vein walls. This study also compared numerical and experimental results regarding compliance and tensile tests to validate the vein material model. The calculated performance concerning expansion and crimping, as well as the release of the stent into a venous vessel, demonstrated the suitability of the stent design for minimally invasive application.https://doi.org/10.1515/cdbme-2019-0120finite-element analysisvenous valve prosthesisvenous material model |
| spellingShingle | Schubert Julia Schümann Kerstin Kischkel Sabine Schmidt Wolfram Grabow Niels Stiehm Michael Pfensig Sylvia Schmitz Klaus-Peter Keiler Jonas Wree Andreas Numerical simulation of the functionality of a stent structure for venous valve prostheses Current Directions in Biomedical Engineering finite-element analysis venous valve prosthesis venous material model |
| title | Numerical simulation of the functionality of a stent structure for venous valve prostheses |
| title_full | Numerical simulation of the functionality of a stent structure for venous valve prostheses |
| title_fullStr | Numerical simulation of the functionality of a stent structure for venous valve prostheses |
| title_full_unstemmed | Numerical simulation of the functionality of a stent structure for venous valve prostheses |
| title_short | Numerical simulation of the functionality of a stent structure for venous valve prostheses |
| title_sort | numerical simulation of the functionality of a stent structure for venous valve prostheses |
| topic | finite-element analysis venous valve prosthesis venous material model |
| url | https://doi.org/10.1515/cdbme-2019-0120 |
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