Strategy to Enhance Anticancer Activity and Induced Immunogenic Cell Death of Antimicrobial Peptides by Using Non-Nature Amino Acid Substitutions

Strategy to Enhance Anticancer Activity and Induced Immunogenic Cell Death of Antimicrobial Peptides by Using Non-Nature Amino Acid Substitutions

There is an urgent and imminent need to develop new agents to fight against cancer. In addition to the antimicrobial and anti-inflammatory activities, many antimicrobial peptides can bind to and lyse cancer cells. P-113, a 12-amino acid clinically active histatin-rich peptide, was found to possess a...

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Bibliographic Details
Main Authors: Yu-Huan Cheah, Chun-Yu Liu, Bak-Sau Yip, Chih-Lung Wu, Kuang-Li Peng, Jya-Wei Cheng
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Biomedicines
Subjects:
antimicrobial peptides
oncolytic peptides
cancer
membrane integrity
bulky non-nature amino acid
DAMPs
Online Access:https://www.mdpi.com/2227-9059/10/5/1097

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