Impact and Advances in the Role of Bacterial Extracellular Vesicles in Neurodegenerative Disease and Its Therapeutics
Bacterial Extracellular Vesicles (BEVs) possess the capability of intracellular interactions with other cells, and, hence, can be utilized as an efficient cargo for worldwide delivery of therapeutic substances such as monoclonal antibodies, proteins, plasmids, siRNA, and small molecules for the trea...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/7/2056 |
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| author | Ashok Iyaswamy Kejia Lu Xin-Jie Guan Yuxuan Kan Chengfu Su Jia Liu Ravindran Jaganathan Karthick Vasudevan Jeyakumari Paul Abhimanyu Thakur Min Li |
| author_facet | Ashok Iyaswamy Kejia Lu Xin-Jie Guan Yuxuan Kan Chengfu Su Jia Liu Ravindran Jaganathan Karthick Vasudevan Jeyakumari Paul Abhimanyu Thakur Min Li |
| author_sort | Ashok Iyaswamy |
| collection | DOAJ |
| description | Bacterial Extracellular Vesicles (BEVs) possess the capability of intracellular interactions with other cells, and, hence, can be utilized as an efficient cargo for worldwide delivery of therapeutic substances such as monoclonal antibodies, proteins, plasmids, siRNA, and small molecules for the treatment of neurodegenerative diseases (NDs). BEVs additionally possess a remarkable capacity for delivering these therapeutics across the blood–brain barrier to treat Alzheimer’s disease (AD). This review summarizes the role and advancement of BEVs for NDs, AD, and their treatment. Additionally, it investigates the critical BEV networks in the microbiome–gut–brain axis, their defensive and offensive roles in NDs, and their interaction with NDs. Furthermore, the part of BEVs in the neuroimmune system and their interference with ND, as well as the risk factors made by BEVs in the autophagy–lysosomal pathway and their potential outcomes on ND, are all discussed. To conclude, this review aims to gain a better understanding of the credentials of BEVs in NDs and possibly discover new therapeutic strategies. |
| first_indexed | 2024-03-11T01:17:07Z |
| format | Article |
| id | doaj.art-e0d8b1fd825748a1bfc2ed5f40939f67 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T01:17:07Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-e0d8b1fd825748a1bfc2ed5f40939f672023-11-18T18:28:50ZengMDPI AGBiomedicines2227-90592023-07-01117205610.3390/biomedicines11072056Impact and Advances in the Role of Bacterial Extracellular Vesicles in Neurodegenerative Disease and Its TherapeuticsAshok Iyaswamy0Kejia Lu1Xin-Jie Guan2Yuxuan Kan3Chengfu Su4Jia Liu5Ravindran Jaganathan6Karthick Vasudevan7Jeyakumari Paul8Abhimanyu Thakur9Min Li10Mr. & Mrs. Ko Chi-Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, ChinaMr. & Mrs. Ko Chi-Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, ChinaMr. & Mrs. Ko Chi-Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, ChinaMr. & Mrs. Ko Chi-Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, ChinaMr. & Mrs. Ko Chi-Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, ChinaMr. & Mrs. Ko Chi-Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, ChinaPreclinical Department, Faculty of Medicine, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh 30450, MalaysiaDepartment of Biotechnology, REVA University, Bangalore 560064, IndiaDepartment of Physiology, Dr. ALM PG Institute of Basic Medical Sciences, University of Madras, Chennai 600005, IndiaPritzker School of Molecular Engineering, Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USAMr. & Mrs. Ko Chi-Ming Centre for Parkinson’s Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, ChinaBacterial Extracellular Vesicles (BEVs) possess the capability of intracellular interactions with other cells, and, hence, can be utilized as an efficient cargo for worldwide delivery of therapeutic substances such as monoclonal antibodies, proteins, plasmids, siRNA, and small molecules for the treatment of neurodegenerative diseases (NDs). BEVs additionally possess a remarkable capacity for delivering these therapeutics across the blood–brain barrier to treat Alzheimer’s disease (AD). This review summarizes the role and advancement of BEVs for NDs, AD, and their treatment. Additionally, it investigates the critical BEV networks in the microbiome–gut–brain axis, their defensive and offensive roles in NDs, and their interaction with NDs. Furthermore, the part of BEVs in the neuroimmune system and their interference with ND, as well as the risk factors made by BEVs in the autophagy–lysosomal pathway and their potential outcomes on ND, are all discussed. To conclude, this review aims to gain a better understanding of the credentials of BEVs in NDs and possibly discover new therapeutic strategies.https://www.mdpi.com/2227-9059/11/7/2056bacterial extracellular vesiclestherapeuticsneurodegenerative diseaseAlzheimer’s diseasenanocarriers |
| spellingShingle | Ashok Iyaswamy Kejia Lu Xin-Jie Guan Yuxuan Kan Chengfu Su Jia Liu Ravindran Jaganathan Karthick Vasudevan Jeyakumari Paul Abhimanyu Thakur Min Li Impact and Advances in the Role of Bacterial Extracellular Vesicles in Neurodegenerative Disease and Its Therapeutics Biomedicines bacterial extracellular vesicles therapeutics neurodegenerative disease Alzheimer’s disease nanocarriers |
| title | Impact and Advances in the Role of Bacterial Extracellular Vesicles in Neurodegenerative Disease and Its Therapeutics |
| title_full | Impact and Advances in the Role of Bacterial Extracellular Vesicles in Neurodegenerative Disease and Its Therapeutics |
| title_fullStr | Impact and Advances in the Role of Bacterial Extracellular Vesicles in Neurodegenerative Disease and Its Therapeutics |
| title_full_unstemmed | Impact and Advances in the Role of Bacterial Extracellular Vesicles in Neurodegenerative Disease and Its Therapeutics |
| title_short | Impact and Advances in the Role of Bacterial Extracellular Vesicles in Neurodegenerative Disease and Its Therapeutics |
| title_sort | impact and advances in the role of bacterial extracellular vesicles in neurodegenerative disease and its therapeutics |
| topic | bacterial extracellular vesicles therapeutics neurodegenerative disease Alzheimer’s disease nanocarriers |
| url | https://www.mdpi.com/2227-9059/11/7/2056 |
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