Lectinhystochemical investigation of rat lung and kidney embryogenesis in conditions of damaging factors absence and under paracetamol and nimesulide influence
467 rat embryos in the age from 13 to 22 day of the intrauterine life without visible damaging factors and under the influence of a therapeutic, subtoxic, toxic dose of paracetamol and nimesulide were investigated. Glycopolymers have been identified by three lectins, conjugated with peroxidase of ho...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy
2009-01-01
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| Series: | Морфологія |
| Subjects: | |
| Online Access: | http://www.morphology.dp.ua/_pub/MORPHO-2009-03-03/09hsvpin.pdf |
| _version_ | 1811295734057664512 |
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| author | Kcharchenko S.V. Shapovalova Ye.Yu. |
| author_facet | Kcharchenko S.V. Shapovalova Ye.Yu. |
| author_sort | Kcharchenko S.V. |
| collection | DOAJ |
| description | 467 rat embryos in the age from 13 to 22 day of the intrauterine life without visible damaging factors and under the influence of a therapeutic, subtoxic, toxic dose of paracetamol and nimesulide were investigated. Glycopolymers have been identified by three lectins, conjugated with peroxidase of horse-radish. It is established, that in cells and extracellular matrix of developing rat lungs and definitive kidney of control group contain peanut, soya and ricina glycopolymers. In process of control group rat lungs and definitive kidney embryogenesis there is constant lectin-receptor system redistribution. Paracetamol and nimesulide ingestion to pregnant rats leads to the redistribution of glycopolymers quantity and histotopogra-phy – receptors of soya, peanut and ricina lectins, changed in comparison with norm. Therapeutic and toxic dose of paraceta-mol and a toxic dose of nimesulide most strongly change histotopography and the quantity of lectins soya, peanut and ricina receptors in lungs. In definitive kidneys the therapeutic dose of paracetamol and a toxic dose of nimesulide has similar influ-ence. |
| first_indexed | 2024-04-13T05:37:59Z |
| format | Article |
| id | doaj.art-e0daf4e89b88415ea77390fadc740dab |
| institution | Directory Open Access Journal |
| issn | 1997-9665 |
| language | Russian |
| last_indexed | 2024-04-13T05:37:59Z |
| publishDate | 2009-01-01 |
| publisher | Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy |
| record_format | Article |
| series | Морфологія |
| spelling | doaj.art-e0daf4e89b88415ea77390fadc740dab2022-12-22T03:00:12ZrusMinistry of Health of Ukraine. Dnipropetrovsk Medical AcademyМорфологія1997-96652009-01-0133131135Lectinhystochemical investigation of rat lung and kidney embryogenesis in conditions of damaging factors absence and under paracetamol and nimesulide influenceKcharchenko S.V.Shapovalova Ye.Yu.467 rat embryos in the age from 13 to 22 day of the intrauterine life without visible damaging factors and under the influence of a therapeutic, subtoxic, toxic dose of paracetamol and nimesulide were investigated. Glycopolymers have been identified by three lectins, conjugated with peroxidase of horse-radish. It is established, that in cells and extracellular matrix of developing rat lungs and definitive kidney of control group contain peanut, soya and ricina glycopolymers. In process of control group rat lungs and definitive kidney embryogenesis there is constant lectin-receptor system redistribution. Paracetamol and nimesulide ingestion to pregnant rats leads to the redistribution of glycopolymers quantity and histotopogra-phy – receptors of soya, peanut and ricina lectins, changed in comparison with norm. Therapeutic and toxic dose of paraceta-mol and a toxic dose of nimesulide most strongly change histotopography and the quantity of lectins soya, peanut and ricina receptors in lungs. In definitive kidneys the therapeutic dose of paracetamol and a toxic dose of nimesulide has similar influ-ence.http://www.morphology.dp.ua/_pub/MORPHO-2009-03-03/09hsvpin.pdfrat’s embryogenesislungkidneyparacetamolnimesulidelectins |
| spellingShingle | Kcharchenko S.V. Shapovalova Ye.Yu. Lectinhystochemical investigation of rat lung and kidney embryogenesis in conditions of damaging factors absence and under paracetamol and nimesulide influence Морфологія rat’s embryogenesis lung kidney paracetamol nimesulide lectins |
| title | Lectinhystochemical investigation of rat lung and kidney embryogenesis in conditions of damaging factors absence and under paracetamol and nimesulide influence |
| title_full | Lectinhystochemical investigation of rat lung and kidney embryogenesis in conditions of damaging factors absence and under paracetamol and nimesulide influence |
| title_fullStr | Lectinhystochemical investigation of rat lung and kidney embryogenesis in conditions of damaging factors absence and under paracetamol and nimesulide influence |
| title_full_unstemmed | Lectinhystochemical investigation of rat lung and kidney embryogenesis in conditions of damaging factors absence and under paracetamol and nimesulide influence |
| title_short | Lectinhystochemical investigation of rat lung and kidney embryogenesis in conditions of damaging factors absence and under paracetamol and nimesulide influence |
| title_sort | lectinhystochemical investigation of rat lung and kidney embryogenesis in conditions of damaging factors absence and under paracetamol and nimesulide influence |
| topic | rat’s embryogenesis lung kidney paracetamol nimesulide lectins |
| url | http://www.morphology.dp.ua/_pub/MORPHO-2009-03-03/09hsvpin.pdf |
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