Recent Achievements in Electrochemical and Optical Nucleic Acids Based Detection of Metal Ions
Recently nucleic acids gained considerable attention as selective receptors of metal ions. This is because of the possibility of adjusting their sequences in new aptamers selection, as well as the convenience of elaborating new detection mechanisms. Such a flexibility allows for easy utilization of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/21/7481 |
| _version_ | 1827645961642442752 |
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| author | Marta Jarczewska Anna Szymczyk Joanna Zajda Marcin Olszewski Robert Ziółkowski Elżbieta Malinowska |
| author_facet | Marta Jarczewska Anna Szymczyk Joanna Zajda Marcin Olszewski Robert Ziółkowski Elżbieta Malinowska |
| author_sort | Marta Jarczewska |
| collection | DOAJ |
| description | Recently nucleic acids gained considerable attention as selective receptors of metal ions. This is because of the possibility of adjusting their sequences in new aptamers selection, as well as the convenience of elaborating new detection mechanisms. Such a flexibility allows for easy utilization of newly emerging nanomaterials for the development of detection devices. This, in turn, can significantly increase, e.g., analytical signal intensity, both optical and electrochemical, and the same can allow for obtaining exceptionally low detection limits and fast biosensor responses. All these properties, together with low power consumption, make nucleic acids biosensors perfect candidates as detection elements of fully automatic portable microfluidic devices. This review provides current progress in nucleic acids application in monitoring environmentally and clinically important metal ions in the electrochemical or optical manner. In addition, several examples of such biosensor applications in portable microfluidic devices are shown. |
| first_indexed | 2024-03-09T18:48:24Z |
| format | Article |
| id | doaj.art-e0ddb2bd669c49e98dff2fac31c52bbc |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T18:48:24Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e0ddb2bd669c49e98dff2fac31c52bbc2023-11-24T06:04:56ZengMDPI AGMolecules1420-30492022-11-012721748110.3390/molecules27217481Recent Achievements in Electrochemical and Optical Nucleic Acids Based Detection of Metal IonsMarta Jarczewska0Anna Szymczyk1Joanna Zajda2Marcin Olszewski3Robert Ziółkowski4Elżbieta Malinowska5Chair of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Stanisława Noakowskiego 3, 00-664 Warsaw, PolandChair of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Stanisława Noakowskiego 3, 00-664 Warsaw, PolandChair of Analytical Chemistry, Faculty of Chemistry, Warsaw University of Technology, Stanisława Noakowskiego 3, 00-664 Warsaw, PolandChair of Drug and Cosmetics Biotechnology, Faculty of Chemistry, Warsaw University ofTechnology, Koszykowa 75, 00-664 Warsaw, PolandChair of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Stanisława Noakowskiego 3, 00-664 Warsaw, PolandChair of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Stanisława Noakowskiego 3, 00-664 Warsaw, PolandRecently nucleic acids gained considerable attention as selective receptors of metal ions. This is because of the possibility of adjusting their sequences in new aptamers selection, as well as the convenience of elaborating new detection mechanisms. Such a flexibility allows for easy utilization of newly emerging nanomaterials for the development of detection devices. This, in turn, can significantly increase, e.g., analytical signal intensity, both optical and electrochemical, and the same can allow for obtaining exceptionally low detection limits and fast biosensor responses. All these properties, together with low power consumption, make nucleic acids biosensors perfect candidates as detection elements of fully automatic portable microfluidic devices. This review provides current progress in nucleic acids application in monitoring environmentally and clinically important metal ions in the electrochemical or optical manner. In addition, several examples of such biosensor applications in portable microfluidic devices are shown.https://www.mdpi.com/1420-3049/27/21/7481aptamersnucleic acidsmetal ionselectrochemistryoptical detection methodsnanomaterials |
| spellingShingle | Marta Jarczewska Anna Szymczyk Joanna Zajda Marcin Olszewski Robert Ziółkowski Elżbieta Malinowska Recent Achievements in Electrochemical and Optical Nucleic Acids Based Detection of Metal Ions Molecules aptamers nucleic acids metal ions electrochemistry optical detection methods nanomaterials |
| title | Recent Achievements in Electrochemical and Optical Nucleic Acids Based Detection of Metal Ions |
| title_full | Recent Achievements in Electrochemical and Optical Nucleic Acids Based Detection of Metal Ions |
| title_fullStr | Recent Achievements in Electrochemical and Optical Nucleic Acids Based Detection of Metal Ions |
| title_full_unstemmed | Recent Achievements in Electrochemical and Optical Nucleic Acids Based Detection of Metal Ions |
| title_short | Recent Achievements in Electrochemical and Optical Nucleic Acids Based Detection of Metal Ions |
| title_sort | recent achievements in electrochemical and optical nucleic acids based detection of metal ions |
| topic | aptamers nucleic acids metal ions electrochemistry optical detection methods nanomaterials |
| url | https://www.mdpi.com/1420-3049/27/21/7481 |
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