A Natural Variation of Fumonisin Gene Cluster Associated with Fumonisin Production Difference in <i>Fusarium fujikuroi</i>
<i>Fusarium fujikuroi</i>, a member of the <i>Fusarium fujikuroi</i> species complex, stands out as a rice bakanae disease pathogen with a high production of gibberellic acid. Not all, but some <i>F. fujikuroi</i> strains are known to produce a carcinogenic mycoto...
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MDPI AG
2019-04-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/11/4/200 |
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| author | Sharmin Sultana Miha Kitajima Hironori Kobayashi Hiroyuki Nakagawa Masafumi Shimizu Koji Kageyama Haruhisa Suga |
| author_facet | Sharmin Sultana Miha Kitajima Hironori Kobayashi Hiroyuki Nakagawa Masafumi Shimizu Koji Kageyama Haruhisa Suga |
| author_sort | Sharmin Sultana |
| collection | DOAJ |
| description | <i>Fusarium fujikuroi</i>, a member of the <i>Fusarium fujikuroi</i> species complex, stands out as a rice bakanae disease pathogen with a high production of gibberellic acid. Not all, but some <i>F. fujikuroi</i> strains are known to produce a carcinogenic mycotoxin fumonisin. Fumonisin biosynthesis is dependent on the FUM cluster composed of 16 <i>FUM</i> genes. The FUM cluster was detected not only from a fumonisin producing strain, but also from a fumonisin nonproducing strain that does not produce a detectable level of fumonisin. Genetic mapping indicated the causative mutation(s) of fumonisin nonproduction is present in the FUM cluster of the fumonisin nonproducing strain. Comparative analyses of <i>FUM</i> genes between the fumonisin producing and the nonproducing strains and gene complementation indicated that causative mutation of fumonisin nonproduction is not a single occurrence and the mutations are distributed in <i>FUM21</i> and <i>FUM7</i>. Our research revealed a natural variation in the FUM cluster involving fumonisin production difference in <i>F. fujikuroi</i>. |
| first_indexed | 2024-04-11T11:01:21Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T11:01:21Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-e0e0b9009ae94ad3bb50fcac3c4e69412022-12-22T04:28:37ZengMDPI AGToxins2072-66512019-04-0111420010.3390/toxins11040200toxins11040200A Natural Variation of Fumonisin Gene Cluster Associated with Fumonisin Production Difference in <i>Fusarium fujikuroi</i>Sharmin Sultana0Miha Kitajima1Hironori Kobayashi2Hiroyuki Nakagawa3Masafumi Shimizu4Koji Kageyama5Haruhisa Suga6The United Graduate School of Agricultural Science, Gifu University, Gifu 501-1193, JapanFaculty of Applied Biological Sciences, Gifu University, Gifu 501-1193, JapanFaculty of Applied Biological Sciences, Gifu University, Gifu 501-1193, JapanFaculty of National Food Research Institute, NARO, Tsukuba 305-8642, JapanFaculty of Applied Biological Sciences, Gifu University, Gifu 501-1193, JapanRiver Basin Research Center, Gifu University, Gifu 501-1193, JapanLife Science Research Center, Gifu University, Gifu 501-1193, Japan<i>Fusarium fujikuroi</i>, a member of the <i>Fusarium fujikuroi</i> species complex, stands out as a rice bakanae disease pathogen with a high production of gibberellic acid. Not all, but some <i>F. fujikuroi</i> strains are known to produce a carcinogenic mycotoxin fumonisin. Fumonisin biosynthesis is dependent on the FUM cluster composed of 16 <i>FUM</i> genes. The FUM cluster was detected not only from a fumonisin producing strain, but also from a fumonisin nonproducing strain that does not produce a detectable level of fumonisin. Genetic mapping indicated the causative mutation(s) of fumonisin nonproduction is present in the FUM cluster of the fumonisin nonproducing strain. Comparative analyses of <i>FUM</i> genes between the fumonisin producing and the nonproducing strains and gene complementation indicated that causative mutation of fumonisin nonproduction is not a single occurrence and the mutations are distributed in <i>FUM21</i> and <i>FUM7</i>. Our research revealed a natural variation in the FUM cluster involving fumonisin production difference in <i>F. fujikuroi</i>.https://www.mdpi.com/2072-6651/11/4/200rice bakanaepolyketide mycotoxingene diversitytranscriptional regulatorpre-termination |
| spellingShingle | Sharmin Sultana Miha Kitajima Hironori Kobayashi Hiroyuki Nakagawa Masafumi Shimizu Koji Kageyama Haruhisa Suga A Natural Variation of Fumonisin Gene Cluster Associated with Fumonisin Production Difference in <i>Fusarium fujikuroi</i> Toxins rice bakanae polyketide mycotoxin gene diversity transcriptional regulator pre-termination |
| title | A Natural Variation of Fumonisin Gene Cluster Associated with Fumonisin Production Difference in <i>Fusarium fujikuroi</i> |
| title_full | A Natural Variation of Fumonisin Gene Cluster Associated with Fumonisin Production Difference in <i>Fusarium fujikuroi</i> |
| title_fullStr | A Natural Variation of Fumonisin Gene Cluster Associated with Fumonisin Production Difference in <i>Fusarium fujikuroi</i> |
| title_full_unstemmed | A Natural Variation of Fumonisin Gene Cluster Associated with Fumonisin Production Difference in <i>Fusarium fujikuroi</i> |
| title_short | A Natural Variation of Fumonisin Gene Cluster Associated with Fumonisin Production Difference in <i>Fusarium fujikuroi</i> |
| title_sort | natural variation of fumonisin gene cluster associated with fumonisin production difference in i fusarium fujikuroi i |
| topic | rice bakanae polyketide mycotoxin gene diversity transcriptional regulator pre-termination |
| url | https://www.mdpi.com/2072-6651/11/4/200 |
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