Influence of Nitrogen-Doped Carbon Dot and Silver Nanoparticle Modified Carbon Paste Electrodes on the Potentiometric Determination of Tobramycin Sulfate: A Comparative Study
Two inexpensive and simple methods for synthesis of carbon nanodots were applied and compared to each other, namely a hydrothermal and microwave-assisted method. The synthesized carbon nanodots were characterized using transmission electron microscopy (TEM), ultraviolet-visible (UV-Vis), photolumine...
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MDPI AG
2021-03-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/9/3/52 |
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| author | Nermine V. Fares Passant M. Medhat Christine M. El Maraghy Sherif Okeil Miriam F. Ayad |
| author_facet | Nermine V. Fares Passant M. Medhat Christine M. El Maraghy Sherif Okeil Miriam F. Ayad |
| author_sort | Nermine V. Fares |
| collection | DOAJ |
| description | Two inexpensive and simple methods for synthesis of carbon nanodots were applied and compared to each other, namely a hydrothermal and microwave-assisted method. The synthesized carbon nanodots were characterized using transmission electron microscopy (TEM), ultraviolet-visible (UV-Vis), photoluminescence (PL), Fourier transform-infrared spectroscopy (FTIR), and X-ray diffraction (XRD). The synthesized microwave carbon nanodots had smaller particle size and were thus chosen for better electrochemical performance. Therefore, they were used for our modification process. The proposed electrodes performance characteristics were evaluated according to the IUPAC guidelines, showing linear response in the concentration range 10<sup>−6</sup>–10<sup>−2</sup>, 10<sup>−7</sup>–10<sup>−2</sup>, and 10<sup>−8</sup>–10<sup>−2</sup> M of tobramycin with a Nernstian slope of 52.60, 58.34, and 57.32 mV/decade for the bare, silver nanoparticle and carbon nanodots modified carbon paste electrodes, respectively. This developed potentiometric method was used for quantification of tobramycin in its co-formulated dosage form and spiked human plasma with good recovery percentages and without interference of the co-formulated drug loteprednol etabonate and excipients. |
| first_indexed | 2024-03-09T05:05:29Z |
| format | Article |
| id | doaj.art-e0e40ff736f5446f8e74b6cc6b60f054 |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-03-09T05:05:29Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-e0e40ff736f5446f8e74b6cc6b60f0542023-12-03T12:55:32ZengMDPI AGChemosensors2227-90402021-03-01935210.3390/chemosensors9030052Influence of Nitrogen-Doped Carbon Dot and Silver Nanoparticle Modified Carbon Paste Electrodes on the Potentiometric Determination of Tobramycin Sulfate: A Comparative StudyNermine V. Fares0Passant M. Medhat1Christine M. El Maraghy2Sherif Okeil3Miriam F. Ayad4Analytical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo 11566, EgyptAnalytical Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 6th of October City 11787, EgyptAnalytical Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 6th of October City 11787, EgyptAnalytical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo 11566, EgyptAnalytical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo 11566, EgyptTwo inexpensive and simple methods for synthesis of carbon nanodots were applied and compared to each other, namely a hydrothermal and microwave-assisted method. The synthesized carbon nanodots were characterized using transmission electron microscopy (TEM), ultraviolet-visible (UV-Vis), photoluminescence (PL), Fourier transform-infrared spectroscopy (FTIR), and X-ray diffraction (XRD). The synthesized microwave carbon nanodots had smaller particle size and were thus chosen for better electrochemical performance. Therefore, they were used for our modification process. The proposed electrodes performance characteristics were evaluated according to the IUPAC guidelines, showing linear response in the concentration range 10<sup>−6</sup>–10<sup>−2</sup>, 10<sup>−7</sup>–10<sup>−2</sup>, and 10<sup>−8</sup>–10<sup>−2</sup> M of tobramycin with a Nernstian slope of 52.60, 58.34, and 57.32 mV/decade for the bare, silver nanoparticle and carbon nanodots modified carbon paste electrodes, respectively. This developed potentiometric method was used for quantification of tobramycin in its co-formulated dosage form and spiked human plasma with good recovery percentages and without interference of the co-formulated drug loteprednol etabonate and excipients.https://www.mdpi.com/2227-9040/9/3/52carbon paste electrodecarbon nanodotssilver nanoparticleshydrothermal and microwave assisted methodstobramycin sulfate |
| spellingShingle | Nermine V. Fares Passant M. Medhat Christine M. El Maraghy Sherif Okeil Miriam F. Ayad Influence of Nitrogen-Doped Carbon Dot and Silver Nanoparticle Modified Carbon Paste Electrodes on the Potentiometric Determination of Tobramycin Sulfate: A Comparative Study Chemosensors carbon paste electrode carbon nanodots silver nanoparticles hydrothermal and microwave assisted methods tobramycin sulfate |
| title | Influence of Nitrogen-Doped Carbon Dot and Silver Nanoparticle Modified Carbon Paste Electrodes on the Potentiometric Determination of Tobramycin Sulfate: A Comparative Study |
| title_full | Influence of Nitrogen-Doped Carbon Dot and Silver Nanoparticle Modified Carbon Paste Electrodes on the Potentiometric Determination of Tobramycin Sulfate: A Comparative Study |
| title_fullStr | Influence of Nitrogen-Doped Carbon Dot and Silver Nanoparticle Modified Carbon Paste Electrodes on the Potentiometric Determination of Tobramycin Sulfate: A Comparative Study |
| title_full_unstemmed | Influence of Nitrogen-Doped Carbon Dot and Silver Nanoparticle Modified Carbon Paste Electrodes on the Potentiometric Determination of Tobramycin Sulfate: A Comparative Study |
| title_short | Influence of Nitrogen-Doped Carbon Dot and Silver Nanoparticle Modified Carbon Paste Electrodes on the Potentiometric Determination of Tobramycin Sulfate: A Comparative Study |
| title_sort | influence of nitrogen doped carbon dot and silver nanoparticle modified carbon paste electrodes on the potentiometric determination of tobramycin sulfate a comparative study |
| topic | carbon paste electrode carbon nanodots silver nanoparticles hydrothermal and microwave assisted methods tobramycin sulfate |
| url | https://www.mdpi.com/2227-9040/9/3/52 |
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