Ultra-high throughput-based screening for the discovery of antiplatelet drugs affecting receptor dependent calcium signaling dynamics

Ultra-high throughput-based screening for the discovery of antiplatelet drugs affecting receptor dependent calcium signaling dynamics

Abstract Distinct platelet activation patterns are elicited by the tyrosine kinase-linked collagen receptor glycoprotein VI (GPVI) and the G-protein coupled protease-activated receptors (PAR1/4) for thrombin. This is reflected in the different platelet Ca2+ responses induced by the GPVI agonist coll...

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Bibliographic Details
Main Authors: Delia I. Fernández, Sara Troitiño, Vladimír Sobota, Bibian M. E. Tullemans, Jinmi Zou, Helma van den Hurk, Ángel García, Saman Honarnejad, Marijke J. E. Kuijpers, Johan W. M. Heemskerk
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Subjects:
Collagen
Cytosolic calcium
Glycoprotein VI
Prestwick library
Thrombin
Thrombosis
Online Access:https://doi.org/10.1038/s41598-024-56799-4

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