A Systematic Review of the Effects of High-Fat Diet Exposure on Oocyte and Follicular Quality: A Molecular Point of View
Worldwide, infertility affects between 10 and 15% of reproductive-aged couples. Female infertility represents an increasing health issue, principally in developing countries, as the current inclinations of delaying pregnancy beyond 35 years of age significantly decrease fertility rates. Female infer...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/16/8890 |
| _version_ | 1797409914362003456 |
|---|---|
| author | Francesca Gonnella Fani Konstantinidou Chiara Di Berardino Giulia Capacchietti Alessia Peserico Valentina Russo Barbara Barboni Liborio Stuppia Valentina Gatta |
| author_facet | Francesca Gonnella Fani Konstantinidou Chiara Di Berardino Giulia Capacchietti Alessia Peserico Valentina Russo Barbara Barboni Liborio Stuppia Valentina Gatta |
| author_sort | Francesca Gonnella |
| collection | DOAJ |
| description | Worldwide, infertility affects between 10 and 15% of reproductive-aged couples. Female infertility represents an increasing health issue, principally in developing countries, as the current inclinations of delaying pregnancy beyond 35 years of age significantly decrease fertility rates. Female infertility, commonly imputable to ovulation disorders, can be influenced by several factors, including congenital malformations, hormonal dysfunction, and individual lifestyle choices, such as smoking cigarettes, stress, drug use and physical activity. Moreover, diet-related elements play an important role in the regulation of ovulation. Modern types of diet that encourage a high fat intake exert a particularly negative effect on ovulation, affecting the safety of gametes and the implantation of a healthy embryo. Identifying and understanding the cellular and molecular mechanisms responsible for diet-associated infertility might help clarify the confounding multifaceted elements of infertility and uncover novel, potentially curative treatments. In this view, this systematic revision of literature will summarize the current body of knowledge of the potential effect of high-fat diet (HFD) exposure on oocyte and follicular quality and consequent female reproductive function, with particular reference to molecular mechanisms and pathways. Inflammation, oxidative stress, gene expression and epigenetics represent the main mechanisms associated with mammal folliculogenesis and oogenesis. |
| first_indexed | 2024-03-09T04:21:24Z |
| format | Article |
| id | doaj.art-e0e7f6d9de464eeda0cbde5009e99d5b |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:21:24Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e0e7f6d9de464eeda0cbde5009e99d5b2023-12-03T13:46:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012316889010.3390/ijms23168890A Systematic Review of the Effects of High-Fat Diet Exposure on Oocyte and Follicular Quality: A Molecular Point of ViewFrancesca Gonnella0Fani Konstantinidou1Chiara Di Berardino2Giulia Capacchietti3Alessia Peserico4Valentina Russo5Barbara Barboni6Liborio Stuppia7Valentina Gatta8Department of Psychological Health and Territorial Sciences, School of Medicine and Health Sciences, “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Psychological Health and Territorial Sciences, School of Medicine and Health Sciences, “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyFaculty of Bioscience, Agri-Food and Environmental Technologies, University of Teramo, 64100 Teramo, ItalyFaculty of Bioscience, Agri-Food and Environmental Technologies, University of Teramo, 64100 Teramo, ItalyFaculty of Bioscience, Agri-Food and Environmental Technologies, University of Teramo, 64100 Teramo, ItalyFaculty of Bioscience, Agri-Food and Environmental Technologies, University of Teramo, 64100 Teramo, ItalyFaculty of Bioscience, Agri-Food and Environmental Technologies, University of Teramo, 64100 Teramo, ItalyDepartment of Psychological Health and Territorial Sciences, School of Medicine and Health Sciences, “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Psychological Health and Territorial Sciences, School of Medicine and Health Sciences, “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyWorldwide, infertility affects between 10 and 15% of reproductive-aged couples. Female infertility represents an increasing health issue, principally in developing countries, as the current inclinations of delaying pregnancy beyond 35 years of age significantly decrease fertility rates. Female infertility, commonly imputable to ovulation disorders, can be influenced by several factors, including congenital malformations, hormonal dysfunction, and individual lifestyle choices, such as smoking cigarettes, stress, drug use and physical activity. Moreover, diet-related elements play an important role in the regulation of ovulation. Modern types of diet that encourage a high fat intake exert a particularly negative effect on ovulation, affecting the safety of gametes and the implantation of a healthy embryo. Identifying and understanding the cellular and molecular mechanisms responsible for diet-associated infertility might help clarify the confounding multifaceted elements of infertility and uncover novel, potentially curative treatments. In this view, this systematic revision of literature will summarize the current body of knowledge of the potential effect of high-fat diet (HFD) exposure on oocyte and follicular quality and consequent female reproductive function, with particular reference to molecular mechanisms and pathways. Inflammation, oxidative stress, gene expression and epigenetics represent the main mechanisms associated with mammal folliculogenesis and oogenesis.https://www.mdpi.com/1422-0067/23/16/8890female infertilityhigh-fat dietoogenesisfolliculogenesisgene expressionepigenetics |
| spellingShingle | Francesca Gonnella Fani Konstantinidou Chiara Di Berardino Giulia Capacchietti Alessia Peserico Valentina Russo Barbara Barboni Liborio Stuppia Valentina Gatta A Systematic Review of the Effects of High-Fat Diet Exposure on Oocyte and Follicular Quality: A Molecular Point of View International Journal of Molecular Sciences female infertility high-fat diet oogenesis folliculogenesis gene expression epigenetics |
| title | A Systematic Review of the Effects of High-Fat Diet Exposure on Oocyte and Follicular Quality: A Molecular Point of View |
| title_full | A Systematic Review of the Effects of High-Fat Diet Exposure on Oocyte and Follicular Quality: A Molecular Point of View |
| title_fullStr | A Systematic Review of the Effects of High-Fat Diet Exposure on Oocyte and Follicular Quality: A Molecular Point of View |
| title_full_unstemmed | A Systematic Review of the Effects of High-Fat Diet Exposure on Oocyte and Follicular Quality: A Molecular Point of View |
| title_short | A Systematic Review of the Effects of High-Fat Diet Exposure on Oocyte and Follicular Quality: A Molecular Point of View |
| title_sort | systematic review of the effects of high fat diet exposure on oocyte and follicular quality a molecular point of view |
| topic | female infertility high-fat diet oogenesis folliculogenesis gene expression epigenetics |
| url | https://www.mdpi.com/1422-0067/23/16/8890 |
| work_keys_str_mv | AT francescagonnella asystematicreviewoftheeffectsofhighfatdietexposureonoocyteandfollicularqualityamolecularpointofview AT fanikonstantinidou asystematicreviewoftheeffectsofhighfatdietexposureonoocyteandfollicularqualityamolecularpointofview AT chiaradiberardino asystematicreviewoftheeffectsofhighfatdietexposureonoocyteandfollicularqualityamolecularpointofview AT giuliacapacchietti asystematicreviewoftheeffectsofhighfatdietexposureonoocyteandfollicularqualityamolecularpointofview AT alessiapeserico asystematicreviewoftheeffectsofhighfatdietexposureonoocyteandfollicularqualityamolecularpointofview AT valentinarusso asystematicreviewoftheeffectsofhighfatdietexposureonoocyteandfollicularqualityamolecularpointofview AT barbarabarboni asystematicreviewoftheeffectsofhighfatdietexposureonoocyteandfollicularqualityamolecularpointofview AT liboriostuppia asystematicreviewoftheeffectsofhighfatdietexposureonoocyteandfollicularqualityamolecularpointofview AT valentinagatta asystematicreviewoftheeffectsofhighfatdietexposureonoocyteandfollicularqualityamolecularpointofview AT francescagonnella systematicreviewoftheeffectsofhighfatdietexposureonoocyteandfollicularqualityamolecularpointofview AT fanikonstantinidou systematicreviewoftheeffectsofhighfatdietexposureonoocyteandfollicularqualityamolecularpointofview AT chiaradiberardino systematicreviewoftheeffectsofhighfatdietexposureonoocyteandfollicularqualityamolecularpointofview AT giuliacapacchietti systematicreviewoftheeffectsofhighfatdietexposureonoocyteandfollicularqualityamolecularpointofview AT alessiapeserico systematicreviewoftheeffectsofhighfatdietexposureonoocyteandfollicularqualityamolecularpointofview AT valentinarusso systematicreviewoftheeffectsofhighfatdietexposureonoocyteandfollicularqualityamolecularpointofview AT barbarabarboni systematicreviewoftheeffectsofhighfatdietexposureonoocyteandfollicularqualityamolecularpointofview AT liboriostuppia systematicreviewoftheeffectsofhighfatdietexposureonoocyteandfollicularqualityamolecularpointofview AT valentinagatta systematicreviewoftheeffectsofhighfatdietexposureonoocyteandfollicularqualityamolecularpointofview |