The Humanized Mouse Model: What Added Value Does It Offer for HIV Research?

The Humanized Mouse Model: What Added Value Does It Offer for HIV Research?

In the early 2000s, novel humanized mouse models based on the transplantation of human hematopoietic stem and progenitor cells (HSPCs) into immunocompromised mice were introduced (hu mice). The human HSPCs gave rise to a lymphoid system of human origin. The HIV research community has greatly benefit...

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Bibliographic Details
Main Authors: Luca Baroncini, Simon Bredl, Kadzioch P. Nicole, Roberto F. Speck
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Pathogens
Subjects:
hu mice
HIV
human hematopoietic stem and progenitor cells
bNAbs
gene therapy
pathogenesis
Online Access:https://www.mdpi.com/2076-0817/12/4/608

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