Crystal structures of thymidylate synthase from nematodes, Trichinella spiralis and Caenorhabditis elegans, as a potential template for species-specific drug design

Crystal structures of thymidylate synthase from nematodes, Trichinella spiralis and Caenorhabditis elegans, as a potential template for species-specific drug design

Crystal structures were solved of the binary complexes Trichinella spiralis and Caenorhabditis elegans thymidylate synthases with deoxyuridine monophosphate (dUMP), with crystals obtained by the vapor diffusion method in hanging drops. For the T. spiralis thymidylate synthase-dUMP complex, the diffr...

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Bibliographic Details
Main Authors: Dowierciał Anna, Wilk Piotr, Rypniewski Wojciech, Frączyk Tomasz, Jarmuła Adam, Banaszak Katarzyna, Dąbrowska Magdalena, Cieśla Joanna, Rode Wojciech
Format: Article
Language:English
Published: De Gruyter 2013-06-01
Series:Pteridines
Subjects:
3d structure
nematode
thymidylate synthase
enzymes: thymidylate synthase (ec 2.1.1.45)
pdb reference: trichinella spiralis thymidylate synthase-dump complex, 4g9u; caenorhabditis elegans thymidylate synthase-dump complex, 4irr
Online Access:https://doi.org/10.1515/pterid-2013-0011

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