Role of L-arginine/NO/cGMP/KATP channel signaling pathway in the central and peripheral antinociceptive effect of thymoquinone in rats

Role of L-arginine/NO/cGMP/KATP channel signaling pathway in the central and peripheral antinociceptive effect of thymoquinone in rats

Objective(s): Growing evidence demonstrates that L-arginine/NO/cGMP/KATP channel pathway has a modulatory role in pain perception. Previous studies have shown that thymoquinone exerts antinociceptive effects; however, the mechanisms underlying antinociception induced by thymoquinone have not been fu...

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Bibliographic Details
Main Authors: Siavash Parvardeh, Masoumeh Sabetkasaei, Mahsa Moghimi, Alireza Masoudi, Shiva Ghafghazi, Fatemeh Mahboobifard
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2018-06-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Guanylyl cyclase
Nitric oxide
Pain signaling
Potassium channels
Thymoquinone
Online Access:http://ijbms.mums.ac.ir/article_10674_5d52f7d71006d038714fcf4f7dc1307c.pdf

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