Enhancing microalgal lipid accumulation for biofuel production
Microalgae have high lipid accumulation capacity, high growth rate and high photosynthetic efficiency which are considered as one of the most promising alternative sustainable feedstocks for producing lipid-based biofuels. However, commercialization feasibility of microalgal biofuel production is st...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.1024441/full |
| _version_ | 1811226174491197440 |
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| author | Zhi Zhu Zhi Zhu Zhi Zhu Zhi Zhu Jing Sun Yun Fa Xufeng Liu Peter Lindblad |
| author_facet | Zhi Zhu Zhi Zhu Zhi Zhu Zhi Zhu Jing Sun Yun Fa Xufeng Liu Peter Lindblad |
| author_sort | Zhi Zhu |
| collection | DOAJ |
| description | Microalgae have high lipid accumulation capacity, high growth rate and high photosynthetic efficiency which are considered as one of the most promising alternative sustainable feedstocks for producing lipid-based biofuels. However, commercialization feasibility of microalgal biofuel production is still conditioned to the high production cost. Enhancement of lipid accumulation in microalgae play a significant role in boosting the economics of biofuel production based on microalgal lipid. The major challenge of enhancing microalgal lipid accumulation lies in overcoming the trade-off between microalgal cell growth and lipid accumulation. Substantial approaches including genetic modifications of microalgal strains by metabolic engineering and process regulations of microalgae cultivation by integrating multiple optimization strategies widely applied in industrial microbiology have been investigated. In the present review, we critically discuss recent trends in the application of multiple molecular strategies to construct high performance microalgal strains by metabolic engineering and synergistic strategies of process optimization and stress operation to enhance microalgal lipid accumulation for biofuel production. Additionally, this review aims to emphasize the opportunities and challenges regarding scaled application of the strategic integration and its viability to make microalgal biofuel production a commercial reality in the near future. |
| first_indexed | 2024-04-12T09:19:48Z |
| format | Article |
| id | doaj.art-e0ed60affc6b4f3dafce26e17f13e186 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-12T09:19:48Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-e0ed60affc6b4f3dafce26e17f13e1862022-12-22T03:38:41ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-10-011310.3389/fmicb.2022.10244411024441Enhancing microalgal lipid accumulation for biofuel productionZhi Zhu0Zhi Zhu1Zhi Zhu2Zhi Zhu3Jing Sun4Yun Fa5Xufeng Liu6Peter Lindblad7The Key Laboratory of Biotechnology for Medicinal Plants of Jiangsu Province, School of Life Sciences, Jiangsu Normal University, Xuzhou, ChinaState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, ChinaCAS Key Laboratory of Bio-Based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, ChinaMicrobial Chemistry, Department of Chemistry-Ångström Laboratory, Uppsala University, Uppsala, SwedenThe Key Laboratory of Biotechnology for Medicinal Plants of Jiangsu Province, School of Life Sciences, Jiangsu Normal University, Xuzhou, ChinaCAS Key Laboratory of Bio-Based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, ChinaMicrobial Chemistry, Department of Chemistry-Ångström Laboratory, Uppsala University, Uppsala, SwedenMicrobial Chemistry, Department of Chemistry-Ångström Laboratory, Uppsala University, Uppsala, SwedenMicroalgae have high lipid accumulation capacity, high growth rate and high photosynthetic efficiency which are considered as one of the most promising alternative sustainable feedstocks for producing lipid-based biofuels. However, commercialization feasibility of microalgal biofuel production is still conditioned to the high production cost. Enhancement of lipid accumulation in microalgae play a significant role in boosting the economics of biofuel production based on microalgal lipid. The major challenge of enhancing microalgal lipid accumulation lies in overcoming the trade-off between microalgal cell growth and lipid accumulation. Substantial approaches including genetic modifications of microalgal strains by metabolic engineering and process regulations of microalgae cultivation by integrating multiple optimization strategies widely applied in industrial microbiology have been investigated. In the present review, we critically discuss recent trends in the application of multiple molecular strategies to construct high performance microalgal strains by metabolic engineering and synergistic strategies of process optimization and stress operation to enhance microalgal lipid accumulation for biofuel production. Additionally, this review aims to emphasize the opportunities and challenges regarding scaled application of the strategic integration and its viability to make microalgal biofuel production a commercial reality in the near future.https://www.frontiersin.org/articles/10.3389/fmicb.2022.1024441/fullmicroalgaelipid enhancementbiofuel productionmetabolic engineeringprocess optimization |
| spellingShingle | Zhi Zhu Zhi Zhu Zhi Zhu Zhi Zhu Jing Sun Yun Fa Xufeng Liu Peter Lindblad Enhancing microalgal lipid accumulation for biofuel production Frontiers in Microbiology microalgae lipid enhancement biofuel production metabolic engineering process optimization |
| title | Enhancing microalgal lipid accumulation for biofuel production |
| title_full | Enhancing microalgal lipid accumulation for biofuel production |
| title_fullStr | Enhancing microalgal lipid accumulation for biofuel production |
| title_full_unstemmed | Enhancing microalgal lipid accumulation for biofuel production |
| title_short | Enhancing microalgal lipid accumulation for biofuel production |
| title_sort | enhancing microalgal lipid accumulation for biofuel production |
| topic | microalgae lipid enhancement biofuel production metabolic engineering process optimization |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.1024441/full |
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