miR-155–5p predictive role to decelerate foam cell atherosclerosis through CD36, VAV3, and SOCS1 pathway
MicroRNAs (miRNAs) are noncoding RNA molecules that play a significant role in atherosclerosis pathogenesis through post-transcriptional regulation. In the present work, a bioinformatic analysis using TargetScan and miRdB databases was performed to identify the miRNAs targeting three genes involved...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2021-06-01
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| Series: | Non-coding RNA Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054021000044 |
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| author | Ermin Rachmawati Djanggan Sargowo M. Saifur Rohman Nashi Widodo Umi Kalsum |
| author_facet | Ermin Rachmawati Djanggan Sargowo M. Saifur Rohman Nashi Widodo Umi Kalsum |
| author_sort | Ermin Rachmawati |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are noncoding RNA molecules that play a significant role in atherosclerosis pathogenesis through post-transcriptional regulation. In the present work, a bioinformatic analysis using TargetScan and miRdB databases was performed to identify the miRNAs targeting three genes involved in foam cell atherosclerosis (CD36, Vav3, and SOCS1). A total number of three hundred and sixty-seven miRNAs were recognized and only miR-155–5p was selected for further evaluation based on Venn analysis. Another objective of this study was to evaluate the biological process and regulatory network of miR-155–5p associated with foam cell atherosclerosis using DIANA, DAVID, Cytoscape, and STRING tools. Additionally, the comprehensive literature review was performed to prove the miR-155–5p function in foam cell atherosclerosis. miR-155–5p might be related with ox-LDL uptake and endocytosis in macrophage cell by targeting CD36 and Vav3 genes which was showed from the KEGG pathways hsa04979, hsa04666, hsa04145 H, hsa04810, and GO:0099632, GO:0060100, GO:0010743, GO:001745. Furthermore, miR-155–5p was also predicted to increase the cholesterol efflux from macrophage by inhibit SOCS1 expression based on KEGG pathway hsa04120. Eleven original studies were included in the review and strongly suggest the role of miR-155–5p in foam cell atherosclerosis inhibition. |
| first_indexed | 2024-04-24T08:27:25Z |
| format | Article |
| id | doaj.art-e0edf2c29a6242bcb01c863566bd98fc |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2024-04-24T08:27:25Z |
| publishDate | 2021-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj.art-e0edf2c29a6242bcb01c863566bd98fc2024-04-16T22:05:31ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402021-06-01625969miR-155–5p predictive role to decelerate foam cell atherosclerosis through CD36, VAV3, and SOCS1 pathwayErmin Rachmawati0Djanggan Sargowo1M. Saifur Rohman2Nashi Widodo3Umi Kalsum4Doctoral Program of Medical Science, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Faculty of Medicine and Health Sciences UIN Maulana Malik Ibrahim Malang; Corresponding author. Doctoral Program of Medical Science, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, IndonesiaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Brawijaya Cardiovascular Research CenterDepartment of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang, IndonesiaDepartment of Pharmacology, Faculty of Medicine, Universitas Brawijaya, Malang, IndonesiaMicroRNAs (miRNAs) are noncoding RNA molecules that play a significant role in atherosclerosis pathogenesis through post-transcriptional regulation. In the present work, a bioinformatic analysis using TargetScan and miRdB databases was performed to identify the miRNAs targeting three genes involved in foam cell atherosclerosis (CD36, Vav3, and SOCS1). A total number of three hundred and sixty-seven miRNAs were recognized and only miR-155–5p was selected for further evaluation based on Venn analysis. Another objective of this study was to evaluate the biological process and regulatory network of miR-155–5p associated with foam cell atherosclerosis using DIANA, DAVID, Cytoscape, and STRING tools. Additionally, the comprehensive literature review was performed to prove the miR-155–5p function in foam cell atherosclerosis. miR-155–5p might be related with ox-LDL uptake and endocytosis in macrophage cell by targeting CD36 and Vav3 genes which was showed from the KEGG pathways hsa04979, hsa04666, hsa04145 H, hsa04810, and GO:0099632, GO:0060100, GO:0010743, GO:001745. Furthermore, miR-155–5p was also predicted to increase the cholesterol efflux from macrophage by inhibit SOCS1 expression based on KEGG pathway hsa04120. Eleven original studies were included in the review and strongly suggest the role of miR-155–5p in foam cell atherosclerosis inhibition.http://www.sciencedirect.com/science/article/pii/S2468054021000044miR-155–5pFoam cellCD36Vav3SOCS1 |
| spellingShingle | Ermin Rachmawati Djanggan Sargowo M. Saifur Rohman Nashi Widodo Umi Kalsum miR-155–5p predictive role to decelerate foam cell atherosclerosis through CD36, VAV3, and SOCS1 pathway Non-coding RNA Research miR-155–5p Foam cell CD36 Vav3 SOCS1 |
| title | miR-155–5p predictive role to decelerate foam cell atherosclerosis through CD36, VAV3, and SOCS1 pathway |
| title_full | miR-155–5p predictive role to decelerate foam cell atherosclerosis through CD36, VAV3, and SOCS1 pathway |
| title_fullStr | miR-155–5p predictive role to decelerate foam cell atherosclerosis through CD36, VAV3, and SOCS1 pathway |
| title_full_unstemmed | miR-155–5p predictive role to decelerate foam cell atherosclerosis through CD36, VAV3, and SOCS1 pathway |
| title_short | miR-155–5p predictive role to decelerate foam cell atherosclerosis through CD36, VAV3, and SOCS1 pathway |
| title_sort | mir 155 5p predictive role to decelerate foam cell atherosclerosis through cd36 vav3 and socs1 pathway |
| topic | miR-155–5p Foam cell CD36 Vav3 SOCS1 |
| url | http://www.sciencedirect.com/science/article/pii/S2468054021000044 |
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